Genetic Architecture of Natural Variation Underlying Adult Foraging Behavior That Is Essential for Survival of Drosophila melanogaster

Lee, Yuh Chwen G.; Yang, Qian; Chi, Wanhao; Turkson, Susie A.; Du, Wei A.; Kemkemer, Claus; Zeng, Zhao-Bang; Long, Manyuan; Zhuang, Xiaoxi

doi:10.1093/gbe/evx089

Title: Genetic Architecture of Natural Variation Underlying Adult Foraging Behavior That Is Essential for Survival of Drosophila melanogaster

Journal Article · Mon May 01 00:00:00 EDT 2017 · Genome Biology and Evolution

DOI:https://doi.org/10.1093/gbe/evx089· OSTI ID:1625341

Lee, Yuh Chwen G. ^[1]; Yang, Qian ^[2]; Chi, Wanhao ^[3]; Turkson, Susie A. ^[2]; Du, Wei A. ^[4]; Kemkemer, Claus ^[5]; Zeng, Zhao-Bang ^[6]; Long, Manyuan ^[5]; Zhuang, Xiaoxi ^[2]

Department of Ecology and Evolution, The University of Chicago, Chicago, IL; Present address: Division of Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Department of Molecular Biology and Cell Biology, University of California, Berkeley
Department of Neurobiology, The University of Chicago, Chicago, IL
Department of Neurobiology, The University of Chicago, Chicago, IL; Present address: Committee on Genetics, Genomics & Systems Biology, The University of Chicago, Chicago, IL
Department of Biology, Wayne State University, Detroit, MI
Department of Ecology and Evolution, The University of Chicago, Chicago, IL
Department of Statistical Genetics and Bioinformatics, North Carolina State University, Raleigh, NC

Foraging behavior is critical for the fitness of individuals. However, the genetic basis of variation in foraging behavior and the evolutionary forces underlying such natural variation have rarely been investigated. We developed a systematic approach to assay the variation in survival rate in a foraging environment for adult flies derived from a wild Drosophila melanogaster population. Despite being such an essential trait, there is substantial variation of foraging behavior among D. melanogaster strains. Importantly, we provided the first evaluation of the potential caveats of using inbred Drosophila strains to perform genome-wide association studies on life-history traits, and concluded that inbreeding depression is unlikely a major contributor for the observed large variation in adult foraging behavior. We found that adult foraging behavior has a strong genetic component and, unlike larval foraging behavior, depends on multiple loci. Identified candidate genes are enriched in those with high expression in adult heads and, demonstrated by expression knock down assay, are involved in maintaining normal functions of the nervous system. Our study not only identified candidate genes for foraging behavior that is relevant to individual fitness, but also shed light on the initial stage underlying the evolution of the behavior.

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Research Organization:: Lawrence Berkeley National Lab (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC); National Institutes of Health (NIH)

Grant/Contract Number:: AC02-05CH11231; 1R01GM100768; F32 GM1

OSTI ID:: 1625341

Journal Information:: Genome Biology and Evolution, Vol. 9, Issue 5; ISSN 1759-6653

Publisher:: Society for Molecular Biology and EvolutionCopyright Statement

Country of Publication:: United States

Language:: English

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