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Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques

Journal Article · · Journal of Experimental Medicine
 [1];  [2];  [2];  [2];  [2];  [3];  [2];  [4];  [5];  [5];  [2];  [2];  [5];  [2]
  1. Rockefeller University, New York, NY (United States); DOE/OSTI
  2. Rockefeller University, New York, NY (United States)
  3. Tulane Regional Primate Research Center, Covington, LA (United States)
  4. Emory University, Atlanta, GA (United States)
  5. Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
+ Show Author Affiliations
To determine the role of CD8+ T cells in controlling simian immunodeficiency virus (SIV) replication in vivo, we examined the effect of depleting this cell population using an anti-CD8 monoclonal antibody, OKT8F. There was on average a 99.9% reduction of CD8 cells in peripheral blood in six infected Macaca mulatta treated with OKT8F. The apparent CD8 depletion started 1 h after antibody administration, and low CD8 levels were maintained until day 8. An increase in plasma viremia of one to three orders of magnitude was observed in five of the six macaques. The injection of a control antibody to an infected macaque did not induce a sustained viral load increase, nor did it significantly reduce the number of CD8+ T cells. These results demonstrate that CD8 cells play a crucial role in suppressing SIV replication in vivo.
Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
Bristol Myers Squibb Foundation; Irene Diamond Fund; National Institutes of Health; USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
Grant/Contract Number:
AC52-06NA25396
OSTI ID:
1625181
Journal Information:
Journal of Experimental Medicine, Journal Name: Journal of Experimental Medicine Journal Issue: 6 Vol. 189; ISSN 0022-1007
Publisher:
Rockefeller University PressCopyright Statement
Country of Publication:
United States
Language:
English

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59 BASIC BIOLOGICAL SCIENCES
OKT8
cytotoxic T lymphocyte
immunology
macaque
research and experimental medicine
simian immunodeficiency virus
viremia