p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis

Fessing, Michael Y.; Mardaryev, Andrei N.; Gdula, Michal R.; Sharov, Andrey A.; Sharova, Tatyana Y.; Rapisarda, Valentina; Gordon, Konstantin B.; Smorodchenko, Anna D.; Poterlowicz, Krzysztof; Ferone, Giustina; Kohwi, Yoshinori; Missero, Caterina; Kohwi-Shigematsu, Terumi; Botchkarev, Vladimir A.

doi:10.1083/jcb.201101148

p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis

Journal Article · Mon Sep 19 00:00:00 EDT 2011 · Journal of Cell Biology

DOI:https://doi.org/10.1083/jcb.201101148· OSTI ID:1625159

Fessing, Michael Y. ^[1]; Mardaryev, Andrei N. ^[2]; Gdula, Michal R. ^[2]; Sharov, Andrey A. ^[3]; Sharova, Tatyana Y. ^[3]; Rapisarda, Valentina ^[2]; Gordon, Konstantin B. ^[2]; Smorodchenko, Anna D. ^[3]; Poterlowicz, Krzysztof ^[2]; Ferone, Giustina ^[4]; Kohwi, Yoshinori ^[5]; Missero, Caterina ^[6]; Kohwi-Shigematsu, Terumi ^[5]; Botchkarev, Vladimir A. ^[7]

Univ. of Bradford (United Kingdom). Centre for Skin Sciences; DOE/OSTI
Univ. of Bradford (United Kingdom). Centre for Skin Sciences
Boston Univ., MA (United States). School of Medicine. Dept. of Dermatology
Fondazione SDN Istituto di Ricovero e Cura a Carattere Scientifico, Napoli (Italy)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division
CEINGE Biotechnologie Avanzate, Naples (Italy); Fondazione SDN Istituto di Ricovero e Cura a Carattere Scientifico, Napoli (Italy)
Univ. of Bradford (United Kingdom). Centre for Skin Sciences; Boston Univ. Boston, MA (United States). School of Medicine. Dept. of Dermatology

During development, multipotent progenitor cells establish tissue-specific programs of gene expression. In this paper, we show that p63 transcription factor, a master regulator of epidermal morphogenesis, executes its function in part by directly regulating expression of the genome organizer Satb1 in progenitor cells. p63 binds to a proximal regulatory region of the Satb1 gene, and p63 ablation results in marked reduction in the Satb1 expression levels in the epidermis. Satb1^-/- mice show impaired epidermal morphology. In Satb1-null epidermis, chromatin architecture of the epidermal differentiation complex locus containing genes associated with epidermal differentiation is altered primarily at its central domain, where Satb1 binding was confirmed by chromatin immunoprecipitation–on-chip analysis. Furthermore, genes within this domain fail to be properly activated upon terminal differentiation. Satb1 expression in p63^+/- skin explants treated with p63 small interfering ribonucleic acid partially restored the epidermal phenotype of p63-deficient mice. These data provide a novel mechanism by which Satb1, a direct downstream target of p63, contributes in epidermal morphogenesis via establishing tissue-specific chromatin organization and gene expression in epidermal progenitor cells.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1625159

Journal Information:: Journal of Cell Biology, Journal Name: Journal of Cell Biology Journal Issue: 6 Vol. 194; ISSN 0021-9525

Publisher:: Rockefeller University PressCopyright Statement

Country of Publication:: United States

Language:: English

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Long non‐coding RNA uc.291 controls epithelial differentiation by interfering with the ACTL6A/BAF complex Panatta, Emanuele; Lena, Anna Maria; Mancini, Mara EMBO reports, Vol. 21, Issue 3 https://doi.org/10.15252/embr.201846734	journal	February 2020
Long non-coding RNA uc.291 controls epithelial differentiation by interfering with the ACTL6A/BAF complex. Panatta, Emanuele; Lena, Anna Maria; Mancini, Mara Wiley-Blackwell https://doi.org/10.17863/cam.50162	journalarticle	January 2020
Molecular Mechanisms of p63-Mediated Squamous Cancer Pathogenesis Moses, Michael A.; George, Andrea L.; Sakakibara, Nozomi International Journal of Molecular Sciences, Vol. 20, Issue 14 https://doi.org/10.3390/ijms20143590	journal	July 2019
p63 Is a Promising Marker in the Diagnosis of Unusual Skin Cancer Smirnov, Artem; Anemona, Lucia; Novelli, Flavia International Journal of Molecular Sciences, Vol. 20, Issue 22 https://doi.org/10.3390/ijms20225781	journal	November 2019

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