Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf)

Hyman, Joel; Chen, Hong; Di Fiore, Pier Paolo; De Camilli, Pietro; Brunger, Axel T.

doi:10.1083/jcb.149.3.537

Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh₂-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn²⁺ Finger Protein (Plzf)

Journal Article · Mon May 01 00:00:00 EDT 2000 · Journal of Cell Biology

DOI:https://doi.org/10.1083/jcb.149.3.537· OSTI ID:1625117

Hyman, Joel ^[1]; Chen, Hong ^[2]; Di Fiore, Pier Paolo ^[3]; De Camilli, Pietro ^[4]; Brunger, Axel T. ^[5]

Yale Univ., New Haven, CT (United States). Dept. of Molecular Biophysics and Biochemistry; Yale Univ., New Haven, CT (United States) Howard Hughes Medical Inst.; DOE/OSTI
Yale Univ., New Haven, CT (United States). Dept. of of Cell Biology; Yale Univ., New Haven, CT (United States). Howard Hughes Medical Inst.
European Inst. of Oncology, Milan (Italy). Dept. of Experimental Oncology
Yale Univ., New Haven, CT (United States). Dept. of of Cell Biology; Yale Univ., New Haven, CT (United States). Howard Hughes Medical Inst.
Yale Univ., New Haven, CT (United States). Dept. of Molecular Biophysics and Biochemistry; Yale Univ., New Haven, CT (United States) Howard Hughes Medical Inst.

Epsin (Eps15 interactor) is a cytosolic protein involved in clathrin-mediated endocytosis via its direct interactions with clathrin, the clathrin adaptor AP-2, and Eps15. The NH₂-terminal portion of epsin contains a phylogenetically conserved module of unknown function, known as the ENTH domain (epsin NH₂-terminal homology domain). We have now solved the crystal structure of rat epsin 1 ENTH domain to 1.8 Å resolution. This domain is structurally similar to armadillo and Heat repeats of β-catenin and karyopherin-β, respectively. We have also identified and characterized the interaction of epsin 1, via the ENTH domain, with the transcription factor promyelocytic leukemia Zn²⁺ finger protein (PLZF). Leptomycin B, an antifungal antibiotic, which inhibits the Crm1- dependent nuclear export pathway, induces an accumulation of epsin 1 in the nucleus. These findings suggest that epsin 1 may function in a signaling pathway connecting the endocytic machinery to the regulation of nuclear function.

View Accepted Manuscript (DOE)

Research Organization:: Yale Univ., New Haven, CT (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

OSTI ID:: 1625117

Journal Information:: Journal of Cell Biology, Journal Name: Journal of Cell Biology Journal Issue: 3 Vol. 149; ISSN 0021-9525

Publisher:: Rockefeller University PressCopyright Statement

Country of Publication:: United States

Language:: English

References (64)

Crystallization of a fragment of human fibronectin: Introduction of methionine by site-directed mutagenesis to allow phasing via selenomethionine Leahy, Daniel J.; Erickson, Harold P.; Aukhil, Ikramuddin Proteins: Structure, Function, and Genetics, Vol. 19, Issue 1 https://doi.org/10.1002/prot.340190107	journal	May 1994
Torsion angle dynamics: Reduced variable conformational sampling enhances crystallographic structure refinement Rice, Luke M.; BrüNger, Axel T. Proteins: Structure, Function, and Genetics, Vol. 19, Issue 4 https://doi.org/10.1002/prot.340190403	journal	August 1994
Protein Structure Comparison by Alignment of Distance Matrices Holm, Liisa; Sander, Chris Journal of Molecular Biology, Vol. 233, Issue 1 https://doi.org/10.1006/jmbi.1993.1489	journal	September 1993
Solvent content of protein crystals Matthews, B. W. Journal of Molecular Biology, Vol. 33, Issue 2 https://doi.org/10.1016/0022-2836(68)90205-2	journal	April 1968
The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex Radu, Aurelian; Moore, Mary Shannon; Blobel, Günter Cell, Vol. 81, Issue 2 https://doi.org/10.1016/0092-8674(95)90331-3	journal	April 1995
WHAT IF: A molecular modeling and drug design program Vriend, G. Journal of Molecular Graphics, Vol. 8, Issue 1 https://doi.org/10.1016/0263-7855(90)80070-v	journal	March 1990
Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression. Nishi, K.; Yoshida, M.; Fujiwara, D. Journal of Biological Chemistry, Vol. 269, Issue 9 https://doi.org/10.1016/s0021-9258(17)37374-x	journal	March 1994
Three-Dimensional Structure of the Armadillo Repeat Region of β-Catenin Huber, Andrew H.; Nelson, W. James; Weis, William I. Cell, Vol. 90, Issue 5 https://doi.org/10.1016/s0092-8674(00)80352-9	journal	September 1997
CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals Fornerod, Maarten; Ohno, Mutsuhito; Yoshida, Minoru Cell, Vol. 90, Issue 6 https://doi.org/10.1016/s0092-8674(00)80371-2	journal	September 1997
A Structural Explanation for the Binding of Multiple Ligands by the α-Adaptin Appendage Domain Owen, David J.; Vallis, Yvonne; Noble, Martin E. M. Cell, Vol. 97, Issue 6 https://doi.org/10.1016/s0092-8674(00)80791-6	journal	June 1999
The Structure of the Protein Phosphatase 2A PR65/A Subunit Reveals the Conformation of Its 15 Tandemly Repeated HEAT Motifs Groves, Matthew R.; Hanlon, Neil; Turowski, Patric Cell, Vol. 96, Issue 1 https://doi.org/10.1016/s0092-8674(00)80963-0	journal	January 1999
Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways Barth, Angela IM; Näthke, Inke S.; Nelson, W. James Current Opinion in Cell Biology, Vol. 9, Issue 5 https://doi.org/10.1016/s0955-0674(97)80122-6	journal	October 1997
Free R value: a novel statistical quantity for assessing the accuracy of crystal structures Brünger, Axel T. Nature, Vol. 355, Issue 6359 https://doi.org/10.1038/355472a0	journal	January 1992
Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia Grignani, Francesco; De Matteis, Silvia; Nervi, Clara Nature, Vol. 391, Issue 6669 https://doi.org/10.1038/35901	journal	February 1998
The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies Ruthardt, Martin; Orleth, Annette; Tomassoni, Lucia Oncogene, Vol. 16, Issue 15 https://doi.org/10.1038/sj.onc.1201722	journal	April 1998
Wrapping the package Ungewickell, Ernst Proceedings of the National Academy of Sciences, Vol. 96, Issue 16 https://doi.org/10.1073/pnas.96.16.8809	journal	August 1999
Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region Kudo, N.; Matsumori, N.; Taoka, H. Proceedings of the National Academy of Sciences, Vol. 96, Issue 16 https://doi.org/10.1073/pnas.96.16.9112	journal	August 1999
Sequence-specific DNA Binding and Transcriptional Regulation by the Promyelocytic Leukemia Zinc Finger Protein Li, Jia-Yuan; English, Milton A.; Ball, Helen J. Journal of Biological Chemistry, Vol. 272, Issue 36 https://doi.org/10.1074/jbc.272.36.22447	journal	September 1997
Splice Variants of Intersectin Are Components of the Endocytic Machinery in Neurons and Nonneuronal Cells Hussain, Natasha K.; Yamabhai, Montarop; Ramjaun, Antoine R. Journal of Biological Chemistry, Vol. 274, Issue 22 https://doi.org/10.1074/jbc.274.22.15671	journal	May 1999
The Epsins Define a Family of Proteins That Interact with Components of the Clathrin Coat and Contain a New Protein Module Rosenthal, Julie A.; Chen, Hong; Slepnev, Vladimir I. Journal of Biological Chemistry, Vol. 274, Issue 48 https://doi.org/10.1074/jbc.274.48.33959	journal	November 1999
The Interaction of Epsin and Eps15 with the Clathrin Adaptor AP-2 Is Inhibited by Mitotic Phosphorylation and Enhanced by Stimulation-dependent Dephosphorylation in Nerve Terminals Chen, Hong; Slepnev, Vladimir I.; Di Fiore, Pier Paolo Journal of Biological Chemistry, Vol. 274, Issue 6 https://doi.org/10.1074/jbc.274.6.3257	journal	February 1999
beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex. Tao, Y. S.; Edwards, R. A.; Tubb, B. Journal of Cell Biology, Vol. 134, Issue 5 https://doi.org/10.1083/jcb.134.5.1271	journal	September 1996
AP-2/Eps15 Interaction Is Required for Receptor-mediated Endocytosis Benmerah, Alexandre; Lamaze, Christophe; Bègue, Bernadette Journal of Cell Biology, Vol. 140, Issue 5 https://doi.org/10.1083/jcb.140.5.1055	journal	March 1998
Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation Livingstone, Craig D.; Barton, Geoffrey J. Bioinformatics, Vol. 9, Issue 6 https://doi.org/10.1093/bioinformatics/9.6.745	journal	January 1993
Transport into and out of the cell nucleus Gorlich, D. The EMBO Journal, Vol. 17, Issue 10 https://doi.org/10.1093/emboj/17.10.2721	journal	May 1998
Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis Wendland, B. The EMBO Journal, Vol. 18, Issue 16 https://doi.org/10.1093/emboj/18.16.4383	journal	August 1999
The role of beta-catenin in cell adhesion, signal transduction, and cancer Bullions, Linda C.; Levine, Arnold J. Current Opinion in Oncology, Vol. 10, Issue 1 https://doi.org/10.1097/00001622-199801000-00013	journal	January 1998
Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module Salcini, A. E.; Confalonieri, S.; Doria, M. Genes & Development, Vol. 11, Issue 17 https://doi.org/10.1101/gad.11.17.2239	journal	September 1997
A highly automated heavy-atom search procedure for macromolecular structures Grosse-Kunstleve, Ralf W.; Brunger, Axel T. Acta Crystallographica Section D Biological Crystallography, Vol. 55, Issue 9 https://doi.org/10.1107/s0907444999007763	journal	September 1999
Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery Kay, Brian K.; Yamabhai, Montarop; Wendland, Beverly Protein Science, Vol. 8, Issue 2 https://doi.org/10.1110/ps.8.2.435	journal	January 1999
Determination of macromolecular structures from anomalous diffraction of synchrotron radiation Hendrickson, W. Science, Vol. 254, Issue 5028 https://doi.org/10.1126/science.1925561	journal	October 1991
Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus Peifer, M. Science, Vol. 287, Issue 5458 https://doi.org/10.1126/science.287.5458.1606	journal	March 2000
The Mdm2 Oncoprotein Interacts with the Cell Fate Regulator Numb Juven-Gershon, Tamar; Shifman, Ohad; Unger, Tamar Molecular and Cellular Biology, Vol. 18, Issue 7 https://doi.org/10.1128/mcb.18.7.3974	journal	July 1998
The Catenin p120 ^ctn Interacts with Kaiso, a Novel BTB/POZ Domain Zinc Finger Transcription Factor Daniel, Juliet M.; Reynolds, Albert B. Molecular and Cellular Biology, Vol. 19, Issue 5 https://doi.org/10.1128/mcb.19.5.3614	journal	May 1999
Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons Nicholls, Anthony; Sharp, Kim A.; Honig, Barry Proteins: Structure, Function, and Genetics, Vol. 11, Issue 4 https://doi.org/10.1002/prot.340110407	journal	December 1991
Mdm2: The Ups and Downs Juven-Gershon, Tamar; Oren, Moshe Molecular Medicine, Vol. 5, Issue 2 https://doi.org/10.1007/BF03402141	journal	February 1999
WHAT IF: A molecular modeling and drug design program Vriend, G. Journal of Molecular Graphics, Vol. 8, Issue 1 https://doi.org/10.1016/0263-7855(90)80070-V	journal	March 1990
Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression. Nishi, K.; Yoshida, M.; Fujiwara, D. Journal of Biological Chemistry, Vol. 269, Issue 9 https://doi.org/10.1016/S0021-9258(17)37374-X	journal	March 1994
[20] Processing of X-ray diffraction data collected in oscillation mode Otwinowski, Zbyszek; Minor, Wladek Macromolecular Crystallography Part A, 307-326 https://doi.org/10.1016/S0076-6879(97)76066-X	book	January 1997
[23] Bayesian statistical viewpoint on structure determination: Basic concepts and examples Bricogne, Gérard Methods in Enzymology https://doi.org/10.1016/S0076-6879(97)76069-5	book	January 1997
Three-Dimensional Structure of the Armadillo Repeat Region of β-Catenin Huber, Andrew H.; Nelson, W. James; Weis, William I. Cell, Vol. 90, Issue 5 https://doi.org/10.1016/S0092-8674(00)80352-9	journal	September 1997
Nuclear Export Receptors: From Importin to Exportin Ullman, Katharine S.; Powers, Maureen A.; Forbes, Douglass J. Cell, Vol. 90, Issue 6 https://doi.org/10.1016/S0092-8674(00)80361-X	journal	September 1997
A Structural Explanation for the Binding of Multiple Ligands by the α-Adaptin Appendage Domain Owen, David J.; Vallis, Yvonne; Noble, Martin E. M. Cell, Vol. 97, Issue 6 https://doi.org/10.1016/S0092-8674(00)80791-6	journal	June 1999
The Structure of the Protein Phosphatase 2A PR65/A Subunit Reveals the Conformation of Its 15 Tandemly Repeated HEAT Motifs Groves, Matthew R.; Hanlon, Neil; Turowski, Patric Cell, Vol. 96, Issue 1 https://doi.org/10.1016/S0092-8674(00)80963-0	journal	January 1999
Transport of Proteins and RNAs in and out of the Nucleus Nakielny, Sara; Dreyfuss, Gideon Cell, Vol. 99, Issue 7 https://doi.org/10.1016/S0092-8674(00)81666-9	journal	December 1999
Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways Barth, Angela IM; Näthke, Inke S.; Nelson, W. James Current Opinion in Cell Biology, Vol. 9, Issue 5 https://doi.org/10.1016/S0955-0674(97)80122-6	journal	October 1997
Transport routes through the nuclear pore complex Pemberton, Lucy F.; Blobel, Günter; Rosenblum, Jonathan S. Current Opinion in Cell Biology, Vol. 10, Issue 3 https://doi.org/10.1016/S0955-0674(98)80016-1	journal	June 1998
β-catenin: a key mediator of Wnt signaling Willert, Karl; Nusse, Roel Current Opinion in Genetics & Development, Vol. 8, Issue 1 https://doi.org/10.1016/S0959-437X(98)80068-3	journal	February 1998
Structure of importin-β bound to the IBB domain of importin-α Cingolani, Gino; Petosa, Carlo; Weis, Karsten Nature, Vol. 399, Issue 6733 https://doi.org/10.1038/20367	journal	May 1999
Structure of the nuclear transport complex karyopherin-β2–Ran˙GppNHp Chook, Yuh Min; Blobel, Günter Nature, Vol. 399, Issue 6733 https://doi.org/10.1038/20375	journal	May 1999
Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis Chen, Hong; Fre, Silvia; Slepnev, Vladimir I. Nature, Vol. 394, Issue 6695 https://doi.org/10.1038/29555	journal	August 1998
Nuclear localization of the p120ctn Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression van Hengel, J.; Vanhoenacker, P.; Staes, K. Proceedings of the National Academy of Sciences, Vol. 96, Issue 14 https://doi.org/10.1073/pnas.96.14.7980	journal	July 1999
Crystal structure of the appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly Traub, L. M.; Downs, M. A.; Westrich, J. L. Proceedings of the National Academy of Sciences, Vol. 96, Issue 16 https://doi.org/10.1073/pnas.96.16.8907	journal	August 1999
Synaptojanin 2, a Novel Synaptojanin Isoform with a Distinct Targeting Domain and Expression Pattern Nemoto, Yasuo; Arribas, Monica; Haffner, Christof Journal of Biological Chemistry, Vol. 272, Issue 49 https://doi.org/10.1074/jbc.272.49.30817	journal	December 1997
The Eps15 Homology (Eh) Domain-Based Interaction between Eps15 and Hrb Connects the Molecular Machinery of Endocytosis to That of Nucleocytosolic Transport Doria, Margherita; Salcini, Anna Elisabetta; Colombo, Emanuela Journal of Cell Biology, Vol. 147, Issue 7 https://doi.org/10.1083/jcb.147.7.1379	journal	December 1999
Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors Nakashima, S. The EMBO Journal, Vol. 18, Issue 13 https://doi.org/10.1093/emboj/18.13.3629	journal	July 1999
The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15 Sengar, A. S. The EMBO Journal, Vol. 18, Issue 5 https://doi.org/10.1093/emboj/18.5.1159	journal	March 1999
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice Thompson, Julie D.; Higgins, Desmond G.; Gibson, Toby J. Nucleic Acids Research, Vol. 22, Issue 22, p. 4673-4680 https://doi.org/10.1093/nar/22.22.4673	journal	January 1994
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures Kraulis, P. J. Journal of Applied Crystallography, Vol. 24, Issue 5 https://doi.org/10.1107/S0021889891004399	journal	October 1991
Histogram matching as a new density modification technique for phase refinement and extension of protein molecules Zhang, K. Y. J.; Main, P. Acta Crystallographica Section A Foundations of Crystallography, Vol. 46, Issue 1 https://doi.org/10.1107/S0108767389009311	journal	January 1990
Improved methods for building protein models in electron density maps and the location of errors in these models Jones, T. A.; Zou, J. Y.; Cowan, S. W. Acta Crystallographica Section A Foundations of Crystallography, Vol. 47, Issue 2, p. 110-119 https://doi.org/10.1107/S0108767390010224	journal	March 1991
Protein Sorting by Transport Vesicles Rothman, J. E.; Wieland, F. T. Science, Vol. 272, Issue 5259 https://doi.org/10.1126/science.272.5259.227	journal	April 1996
The Mdm2 Oncoprotein Interacts with the Cell Fate Regulator Numb Juven-Gershon, Tamar; Shifman, Ohad; Unger, Tamar Molecular and Cellular Biology, Vol. 18, Issue 7 https://doi.org/10.1128/MCB.18.7.3974	journal	July 1998
The Catenin p120 ^ctn Interacts with Kaiso, a Novel BTB/POZ Domain Zinc Finger Transcription Factor Daniel, Juliet M.; Reynolds, Albert B. Molecular and Cellular Biology, Vol. 19, Issue 5 https://doi.org/10.1128/MCB.19.5.3614	journal	May 1999

Cited By (37)

Influence of membrane curvature on the structure of the membrane-associated pleckstrin homology domain of phospholipase C-δ1 Uekama, Naoko; Aoki, Takahiro; Maruoka, Toshihiro Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1788, Issue 12 https://doi.org/10.1016/j.bbamem.2009.10.009	journal	December 2009
Endocytosis: Signaling from Endocytic Membranes to the Nucleus Benmerah, Alexandre Current Biology, Vol. 14, Issue 8 https://doi.org/10.1016/j.cub.2004.03.053	journal	April 2004
A Novel All Helix Fold of the AP180 Amino-Terminal Domain for Phosphoinositide Binding and Clathrin Assembly in Synaptic Vesicle Endocytosis Mao, Yuxin; Chen, Jue; Maynard, Jennifer A. Cell, Vol. 104, Issue 3 https://doi.org/10.1016/s0092-8674(01)00230-6	journal	February 2001
PIP Kinase Iγ Is the Major PI(4,5)P2 Synthesizing Enzyme at the Synapse Wenk, Markus R.; Pellegrini, Lorenzo; Klenchin, Vadim A. Neuron, Vol. 32, Issue 1 https://doi.org/10.1016/s0896-6273(01)00456-1	journal	October 2001
Endocytosis: Why not wait to deubiquitinate? Carthew, Richard W.; Xu, Chunyan Current Biology, Vol. 10, Issue 14 https://doi.org/10.1016/s0960-9822(00)00587-x	journal	July 2000
Vital function of PRELI and essential requirement of its LEA motif McKeller, M. R.; Herrera-Rodriguez, S.; Ma, W. Cell Death & Disease, Vol. 1, Issue 2 https://doi.org/10.1038/cddis.2009.19	journal	February 2010
Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex Banach-Orlowska, Magdalena; Pilecka, Iwona; Torun, Anna Biochemical Journal, Vol. 423, Issue 3 https://doi.org/10.1042/bj20090086	journal	October 2009
Comprehensive nuclear proteome of Arabidopsis obtained by sequential extraction Goto, Chieko; Hashizume, Shoko; Fukao, Yoichiro Nucleus, Vol. 10, Issue 1 https://doi.org/10.1080/19491034.2019.1603093	journal	January 2019
Evidence That Dynamin-2 Functions as a Signal-Transducing Gtpase Fish, Kenneth N.; Schmid, Sandra L.; Damke, Hanna Journal of Cell Biology, Vol. 150, Issue 1 https://doi.org/10.1083/jcb.150.1.145	journal	July 2000
Nucleocytoplasmic Shuttling of Endocytic Proteins Vecchi, Manuela; Polo, Simona; Poupon, Viviane Journal of Cell Biology, Vol. 153, Issue 7 https://doi.org/10.1083/jcb.153.7.1511	journal	June 2001
Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors Mills, Ian G.; Gaughan, Luke; Robson, Craig Journal of Cell Biology, Vol. 170, Issue 2 https://doi.org/10.1083/jcb.200503106	journal	July 2005
Evolutionary analysis of the ENTH/ANTH/VHS protein superfamily reveals a coevolution between membrane trafficking and metabolism De Craene, Johan-Owen; Ripp, Raymond; Lecompte, Odile BMC Genomics, Vol. 13, Issue 1 https://doi.org/10.1186/1471-2164-13-297	journal	January 2012
Eps15: a multifunctional adaptor protein regulating intracellular trafficking van Bergen en Henegouwen, Paul MP Cell Communication and Signaling, Vol. 7, Issue 1 https://doi.org/10.1186/1478-811x-7-24	journal	October 2009
Spare PRELI Gene Loci: Failsafe Chromosome Insurance? Ma, Wenbin; McKeller, Morgan R.; Rangel, Roberto PLoS ONE, Vol. 7, Issue 5 https://doi.org/10.1371/journal.pone.0037949	journal	May 2012
PIP5KIβ Selectively Modulates Apical Endocytosis in Polarized Renal Epithelial Cells Szalinski, Christina M.; Guerriero, Christopher J.; Ruiz, Wily G. PLoS ONE, Vol. 8, Issue 1 https://doi.org/10.1371/journal.pone.0053790	journal	January 2013
Concise Review: Balancing Stem Cell Self-Renewal and Differentiation with PLZF: PLZF Regulates Self-Renewal and Differentiation of Stem Cells Liu, Tong Ming; Lee, Eng Hin; Lim, Bing STEM CELLS, Vol. 34, Issue 2 https://doi.org/10.1002/stem.2270	journal	January 2016
Automated Structure Solution with the PHENIX Suite Zwart, Peter H.; Afonine, Pavel V.; Grosse-Kunstleve, Ralf W. Methods in Molecular Biology https://doi.org/10.1007/978-1-60327-058-8_28	book	January 2008
Endocytosis and signaling cascades: a close encounter Cavalli, Valeria; Corti, Michela; Gruenberg, Jean FEBS Letters, Vol. 498, Issue 2-3 https://doi.org/10.1016/s0014-5793(01)02484-x	journal	June 2001
VHS domain - a longshoreman of vesicle lines Lohi, Olli; Poussu, Anssi; Mao, Yuxin FEBS Letters, Vol. 513, Issue 1 https://doi.org/10.1016/s0014-5793(01)03287-2	journal	December 2001
Phosphoinositide Recognition Domains: Phosphoinositide Recognition Domains Lemmon, Mark A. Traffic, Vol. 4, Issue 4 https://doi.org/10.1034/j.1600-0854.2004.00071.x	journal	April 2003
Curvature of clathrin-coated pits driven by epsin Ford, Marijn G. J.; Mills, Ian G.; Peter, Brian J. Nature, Vol. 419, Issue 6905 https://doi.org/10.1038/nature01020	journal	September 2002
Regulated portals of entry into the cell Conner, Sean D.; Schmid, Sandra L. Nature, Vol. 422, Issue 6927 https://doi.org/10.1038/nature01451	journal	March 2003
A role for Kaiso–p120ctn complexes in cancer? van Roy, Frans M.; McCrea, Pierre D. Nature Reviews Cancer, Vol. 5, Issue 12 https://doi.org/10.1038/nrc1752	journal	November 2005
Vesicular protein transport Schu, P. The Pharmacogenomics Journal, Vol. 1, Issue 4 https://doi.org/10.1038/sj.tpj.6500055	journal	April 2001
Intersectin goes nuclear: secret life of an endocytic protein Alvisi, Gualtiero; Paolini, Lucia; Contarini, Andrea Biochemical Journal, Vol. 475, Issue 8 https://doi.org/10.1042/bcj20170897	journal	April 2018
EHD2 shuttles to the nucleus and represses transcription Pekar, Olga; Benjamin, Sigi; Weidberg, Hilla Biochemical Journal, Vol. 444, Issue 3 https://doi.org/10.1042/bj20111268	journal	May 2012
Excess vacuolar SNAREs drive lysis and Rab bypass fusion Starai, V. J.; Jun, Y.; Wickner, W. Proceedings of the National Academy of Sciences, Vol. 104, Issue 34 https://doi.org/10.1073/pnas.0704741104	journal	August 2007
Unusual Structural Organization of the Endocytic Proteins AP180 and Epsin 1 Kalthoff, Christoph; Alves, Jürgen; Urbanke, Claus Journal of Biological Chemistry, Vol. 277, Issue 10 https://doi.org/10.1074/jbc.m111587200	journal	March 2002
Differential Nucleocytoplasmic Shuttling of β-Arrestins: CHARACTERIZATION OF A LEUCINE-RICH NUCLEAR EXPORT SIGNAL IN β-ARRESTIN2 Scott, Mark G. H.; Le Rouzic, Erwann; Périanin, Axel Journal of Biological Chemistry, Vol. 277, Issue 40 https://doi.org/10.1074/jbc.m207552200	journal	August 2002
Characterization of Mammalian Ecm29, a 26 S Proteasome-associated Protein That Localizes to the Nucleus and Membrane Vesicles Gorbea, Carlos; Goellner, Geoffrey M.; Teter, Ken Journal of Biological Chemistry, Vol. 279, Issue 52 https://doi.org/10.1074/jbc.m410444200	journal	December 2004
Huntingtin Associates with Acidic Phospholipids at the Plasma Membrane Kegel, Kimberly B.; Sapp, Ellen; Yoder, Jennifer Journal of Biological Chemistry, Vol. 280, Issue 43 https://doi.org/10.1074/jbc.m503672200	journal	October 2005
Degradation of Endocytosed Epidermal Growth Factor and Virally Ubiquitinated Major Histocompatibility Complex Class I Is Independent of Mammalian ESCRTII Bowers, Katherine; Piper, Siân C.; Edeling, Melissa A. Journal of Biological Chemistry, Vol. 281, Issue 8 https://doi.org/10.1074/jbc.m508632200	journal	February 2006
Annexin B12 Is a Sensor of Membrane Curvature and Undergoes Major Curvature-dependent Structural Changes Fischer, Torsten; Lu, Lucy; Haigler, Harry T. Journal of Biological Chemistry, Vol. 282, Issue 13 https://doi.org/10.1074/jbc.m611180200	journal	March 2007
A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy Senbonmatsu, T. The EMBO Journal, Vol. 22, Issue 24 https://doi.org/10.1093/emboj/cdg637	journal	December 2003
Rapid chain tracing of polypeptide backbones in electron-density maps Terwilliger, Thomas C. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 3 https://doi.org/10.1107/s0907444910000272	journal	February 2010
Rapid model building of α-helices in electron-density maps Terwilliger, Thomas C. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 3 https://doi.org/10.1107/s0907444910000314	journal	February 2010
Endocytosis and Signaling: Cell Logistics Shape the Eukaryotic Cell Plan Sigismund, Sara; Confalonieri, Stefano; Ciliberto, Andrea Physiological Reviews, Vol. 92, Issue 1 https://doi.org/10.1152/physrev.00005.2011	journal	January 2012

Similar Records

Redox-mediated modification of PLZF by SUMO-1 and ubiquitin

Journal Article · Fri May 16 00:00:00 EDT 2008 · Biochemical and Biophysical Research Communications · OSTI ID:21143689

PLZF-RAR[alpha] fusion proteins generated from the variant t(11; 17)(q23; q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors

Journal Article · Mon Jan 31 23:00:00 EST 1994 · Proceedings of the National Academy of Sciences of the United States of America; (United States) · OSTI ID:7009364

An Armadillo Motif in Ufd3 Interacts with Cdc48 and is Involved in Ubiquitin Homeostasis and Protein Degradation

Journal Article · Wed Dec 31 23:00:00 EST 2008 · Proceedings of the National Academy of Sciences of the United States of America · OSTI ID:980007

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
Eps15 homology domain
catenin
cell biology
clathrin
endocytosis
karyopherin