Cloning and Characterization of a Potassium-Dependent Sodium/Calcium Exchanger in Drosophila

Haug-Collet, K.; Pearson, B.; Webel, R.; Szerencsei, R. T.; Winkfein, R. J.; Schnetkamp, P. P. M.; Colley, N. J.

doi:10.1083/jcb.147.3.659

Cloning and Characterization of a Potassium-Dependent Sodium/Calcium Exchanger in Drosophila

Journal Article · Mon Nov 01 00:00:00 EST 1999 · Journal of Cell Biology

DOI:https://doi.org/10.1083/jcb.147.3.659· OSTI ID:1625116

Haug-Collet, K. ^[1]; Pearson, B. ^[2]; Webel, R. ^[2]; Szerencsei, R. T. ^[3]; Winkfein, R. J. ^[3]; Schnetkamp, P. P. M. ^[3]; Colley, N. J. ^[2]

Univ. of Wisconsin, Madison, WI (United States). Dept. of Genetics. Dept. of Ophthalmology and Visual Sciences; DOE/OSTI
Univ. of Wisconsin, Madison, WI (United States). Dept. of Genetics. Dept. of Ophthalmology and Visual Sciences
Univ. of Calgary, AB (Canada) Faculty of Medicine. Medical Research Council Group on Ion Channels and Transporters. Dept. of Physiology and Biophysics

Sodium/calcium(-potassium) exchangers (NCX and NCKX) are critical for the rapid extrusion of calcium, which follows the stimulation of a variety of excitable cells. To further understand the mechanisms of calcium regulation in signaling, we have cloned a Drosophila sodium/calcium-potassium exchanger, Nckx30C. The overall deduced protein topology for NCKX30C is similar to that of mammalian NCKX, having five membrane-spanning domains in the NH2 terminus separated from six at the COOH-terminal end by a large intracellular loop. We show that NCKX30C functions as a potassium-dependent sodium/calcium exchanger, and is not only expressed in adult neurons as was expected, but is also expressed during ventral nerve cord development in the embryo and in larval imaginal discs. Nckx30C is expressed in a dorsal–ventral pattern in the eye-antennal disc in a pattern that is similar to, but broader than that of wingless, suggesting that large fluxes of calcium may be occurring during imaginal disc development. Nckx30C may not only function in the removal of calcium and maintenance of calcium homeostasis during signaling in the adult, but may also play a critical role in signaling during development.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of Wisconsin, Madison, WI (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

OSTI ID:: 1625116

Journal Information:: Journal of Cell Biology, Journal Name: Journal of Cell Biology Journal Issue: 3 Vol. 147; ISSN 0021-9525

Publisher:: Rockefeller University PressCopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
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development
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Cloning and Characterization of a Potassium-Dependent Sodium/Calcium Exchanger in Drosophila

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