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Detection and characterisation of novel alternative splicing variants of the mitochondrial folate enzyme MTHFD2
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Electrostatics of nanosystems: Application to microtubules and the ribosome
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August 2001 |
Blood-Brain Barrier Disruption and Intra-Arterial Methotrexate-Based Therapy for Newly Diagnosed Primary CNS Lymphoma: A Multi-Institutional Experience
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Solving structures of protein complexes by molecular replacement with Phaser
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Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures
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June 2017 |
Oligomeric Structure of the Human Reduced Folate Carrier: IDENTIFICATION OF HOMO-OLIGOMERS AND DOMINANT-NEGATIVE EFFECTS ON CARRIER EXPRESSION AND FUNCTION
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November 2008 |
Loss of folylpoly-?-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines
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Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells
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Scaffold Repurposing of Old Drugs Towards New Cancer Drug Discovery
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May 2016 |
Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers
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October 2016 |
Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway
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June 2016 |
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March 2000 |
Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia
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Human Cytosolic and Mitochondrial Serine Hydroxymethyltransferase Isoforms in Comparison: Full Kinetic Characterization and Substrate Inhibition Properties
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Personalized medicine in rheumatoid arthritis: methotrexate polyglutamylation revisited
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Cisplatin-based chemoradiotherapy with 5-fluorouracil or pemetrexed in patients with locally advanced, unresectable esophageal squamous cell carcinoma: A retrospective analysis
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April 2017 |
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March 2000 |
Photorespiration: players, partners and origin
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June 2010 |
Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT): Cocrystal Structures of Pyrazolopyrans with Potent Blood- and Liver-Stage Activities
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March 2015 |
High-throughput protein purification and quality assessment for crystallization
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September 2011 |
Structure of a Murine Cytoplasmic Serine Hydroxymethyltransferase Quinonoid Ternary Complex: Evidence for Asymmetric Obligate Dimers †
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The glycine decarboxylase system: a fascinating complex
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April 2001 |
Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior
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A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells
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Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia
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April 2009 |
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Organelle pH in the Arabidopsis Endomembrane System
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Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway
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January 2016 |
Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT 2 by antifolate drugs
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June 2019 |
Pemetrexed (alimta, MTA, multitargeted antifolate, LY231514) for malignant pleural mesothelioma
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August 2003 |
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Computational studies of polyurethanases from Pseudomonas
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January 2021 |
Screening and In Vitro Testing of Antifolate Inhibitors of Human Cytosolic Serine Hydroxymethyltransferase
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February 2015 |
Photorespiration: current status and approaches for metabolic engineering
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June 2010 |
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July 1999 |
Serine hydroxymethyltransferase revisited
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October 2005 |
One-Carbon Metabolism in Health and Disease
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January 2017 |
Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer
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September 2016 |
Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs
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October 2017 |
In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed
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May 2011 |
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December 2009 |
TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential
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January 2020 |
Interaction between glycine decarboxylase, serine hydroxymethyltransferase and tetrahydrofolate polyglutamates in pea leaf mitochondria
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August 1994 |
Serine hydroxymethyltransferase: A model enzyme for mechanistic, structural, and evolutionary studies
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November 2011 |
Predicting Subcellular Localization of Proteins Based on their N-terminal Amino Acid Sequence
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July 2000 |
Chloroplastic Serine Hydroxymethyltransferase From Medicago truncatula: A Structural Characterization
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May 2018 |
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Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria
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Effects of folate and folylpolyglutamyl synthase modulation on chemosensitivity of breast cancer cells
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Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
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Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard
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Exploring the gas access routes in a [NiFeSe] hydrogenase using crystals pressurized with krypton and oxygen
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August 2020 |
Molecular Analysis of Murine Leukemia Cell Lines Resistant to 5,10-Dideazatetrahydrofolate Identifies Several Amino Acids Critical to the Function of Folylpolyglutamate Synthetase
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June 2000 |
Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold
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April 2018 |
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Serine Transhydroxymethylase. Affinity of Tetrahydrofolate Compounds for the Enzyme and Enzyme-Glycine Complex *
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March 1999 |
Therapeutics by Cytotoxic Metabolite Accumulation: Pemetrexed Causes ZMP Accumulation, AMPK Activation, and Mammalian Target of Rapamycin Inhibition
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June 2009 |
PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome
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December 2019 |
Polder maps: improving OMIT maps by excluding bulk solvent
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February 2017 |
Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway
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October 2016 |
Features and development of Coot
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March 2010 |
Folylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis
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October 2016 |
The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases
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May 2019 |
Rapid evolution of mammalian APLP1 as a synaptic adhesion molecule
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May 2021 |
PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations
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July 2004 |
Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications
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February 2007 |
One-carbon metabolism in plants: characterization of a plastid serine hydroxymethyltransferase
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July 2010 |
Current and Emerging Pharmacotherapies for Primary CNS Lymphoma
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January 2012 |