Temporally selective contextual encoding in the dentate gyrus of the hippocampus

Rangel, L. M.; Alexander, A. S.; Aimone, J. B.; Wiles, J.; Gage, F. H.; Chiba, A. A.; Quinn, L. K.

doi:10.1038/ncomms4181

Temporally selective contextual encoding in the dentate gyrus of the hippocampus

Journal Article · Wed Feb 12 00:00:00 EST 2014 · Nature Communications

DOI:https://doi.org/10.1038/ncomms4181· OSTI ID:1623933

Rangel, L. M. ^[1]; Alexander, A. S. ^[2]; Aimone, J. B. ^[3]; Wiles, J. ^[4]; Gage, F. H. ^[5]; Chiba, A. A. ^[6]; Quinn, L. K. ^[2]

Univ. of California, San Diego, CA (United States). program in Neurosciences; Salk Institute for Biological Studies, La Jolla, CA (United States); DOE/OSTI
Univ. of California, San Diego, CA (United States). Dept. of Cognitive Science
Salk Institute for Biological Studies, La Jolla, CA (United States)
Univ. of Queensland, Brisbane, QLD (Australia). School of Information Technology and Electrical Engineering
Univ. of California, San Diego, CA (United States). program in Neurosciences; Salk Institute for Biological Studies, La Jolla, CA (United States)
Univ. of California, San Diego, CA (United States). program in Neurosciences; Univ. of California, San Diego, CA (United States). Dept. of Cognitive Science

A recent model of the hippocampus predicts that the unique properties of the dentate gyrus allow for temporal separation of events. This temporal separation is accomplished in part through the continual generation of new neurons, which, due to a transient window of hyperexcitability, could allow for preferential encoding of information present during their development. Here we obtain in vivo electrophysiological recordings and identify a cell population exhibiting activity that is selective to single contexts when rats experience a long temporal separation between context exposures during training. This selectivity is attenuated as the temporal separation between context exposures is shortened and is further attenuated when neurogenesis is reduced. Our data reveal the existence of a temporal orthogonalizing neuronal code within the dentate gyrus, a hallmark feature of episodic memory.

View Accepted Manuscript (DOE)

Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: National Science Foundation (NSF); USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: NA0003525

OSTI ID:: 1623933

Journal Information:: Nature Communications, Journal Name: Nature Communications Journal Issue: 1 Vol. 5; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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