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Solid cancer incidence other than lung, liver and bone in Mayak workers: 1948–2004

Journal Article · · British Journal of Cancer
DOI:https://doi.org/10.1038/bjc.2013.543· OSTI ID:1623739
 [1];  [2];  [3];  [4]
  1. Public Health England (PHE), Centre for Radiation, Chemical and Environmental Hazards (CRCE), Chilton, Oxfordshire (United Kingdom); DOE/OSTI
  2. Southern Urals Biophysics Institute (SUBI), Ozyorsk (Russian Federation)
  3. Southern Urals Biophysics Institute (SUBI), Ozyorsk (Russian Federation)
  4. Public Health England (PHE), Centre for Radiation, Chemical and Environmental Hazards (CRCE), Chilton, Oxfordshire (United Kingdom)
+ Show Author Affiliations
Background: Cancer incidence in the Mayak Production Association (PA) cohort was analysed to investigate for the first time whether external gamma-ray and internal plutonium exposure are associated with raised incidence of solid cancers other than lung, liver and bone (other solid cancers). Methods: The cohort includes 22 366 workers of both sexes who were first employed between 1948 and 1982. A total of 1447 cases of other solid cancers were registered in the follow-up period until 2004. The Poisson regression was used to estimate the excess relative risk (ERR) per unit of cumulative exposure to plutonium and external gamma-ray. Results: A weak association was found between cumulative exposure to external gamma-ray and the incidence of other solid cancers (ERR/Gy = 0.07; 95% confidence intervals (CIs): 0.01–0.15), but this association lost its significance after adjusting for internal plutonium exposure. There was no indication of any association with plutonium exposure for other solid cancers. Among 16 individual cancer sites, there was a statistically significant association with external exposure for lip cancer (ERR/Gy = 1.74; 95% CI: 0.37; 6.71) and with plutonium exposure for pancreatic cancer (ERR/Gy = 1.58; 95% CI; 0.17; 4.77). Conclusion: This study of Mayak workers does not provide evidence of an increased risk of other solid cancers. The observed increase in the risk of cancer of the lip and pancreas should be treated with caution because of the limited amount of relevant data and because the observations may be simply due to chance.
Research Organization:
Public Health England (PHE), Centre for Radiation, Chemical and Environmental Hazards (CRCE), Chilton, Oxfordshire (United Kingdom)
Sponsoring Organization:
European Commission; USDOE
OSTI ID:
1623739
Journal Information:
British Journal of Cancer, Journal Name: British Journal of Cancer Journal Issue: 7 Vol. 109; ISSN 0007-0920
Publisher:
SpringerCopyright Statement
Country of Publication:
United States
Language:
English

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Cited By (11)

Radiation-related occupational cancer and its recognition criteria in South Korea journal February 2018
Radiation Effects on Mortality from Solid Cancers Other than Lung, Liver, and Bone Cancer in the Mayak Worker Cohort: 1948–2008 journal February 2015
Radiation Risks of Leukemia, Lymphoma and Multiple Myeloma Incidence in the Mayak Cohort: 1948–2004 journal September 2016
Is the Linear No-Threshold Dose-Response Paradigm Still Necessary for the Assessment of Health Effects of Low Dose Radiation? journal January 2016
Hyperacetylation of Cardiac Mitochondrial Proteins Is Associated with Metabolic Impairment and Sirtuin Downregulation after Chronic Total Body Irradiation of ApoE -/- Mice journal October 2019
Dose limits for occupational exposure to ionising radiation and genotoxic carcinogens: a German perspective journal November 2019
Cancer mortality and incidence following external occupational radiation exposure: an update of the 3rd analysis of the UK national registry for radiation workers journal August 2018
Implications of recent epidemiologic studies for the linear nonthreshold model and radiation protection journal August 2018
Radiation epidemiology and health effects following low-level radiation exposure journal September 2019
Typical doses and dose rates in studies pertinent to radiation risk inference at low doses and low dose rates journal February 2018
Risk of malignant skin neoplasms in a cohort of workers occupationally exposed to ionizing radiation at low dose rates journal October 2018

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Related Subjects

60 APPLIED LIFE SCIENCES
Mayak radiation workers
cancer incidence
external gamma radiation
internal plutonium exposure
oncology