Dedifferentiation of Neurons Precedes Tumor Formation in lola Mutants

Southall, Tony D.; Davidson, Catherine M.; Miller, Claire; Carr, Adrian; Brand, Andrea H.

doi:10.1016/j.devcel.2014.01.030

Dedifferentiation of Neurons Precedes Tumor Formation in lola Mutants

Journal Article · Thu Mar 13 04:00:00 EDT 2014 · Developmental Cell

DOI:https://doi.org/10.1016/j.devcel.2014.01.030· OSTI ID:1623658

Southall, Tony D. ^[1]; Davidson, Catherine M. ^[2]; Miller, Claire ^[2]; Carr, Adrian ^[2]; Brand, Andrea H. ^[2]

Univ. of Cambridge (United Kingdom). The Gurdon Inst. Dept. of Physiology, Development and Neuroscience; DOE/OSTI
Univ. of Cambridge (United Kingdom). The Gurdon Inst. Dept. of Physiology, Development and Neuroscience

The ability to reprogram differentiated cells into a pluripotent state has revealed that the differentiated state is plastic and reversible. It is evident, therefore, that mechanisms must be in place to maintain cells in a differentiated state. Transcription factors that specify neuronal characteristics have been well studied, but less is known about the mechanisms that prevent neurons from dedifferentiating to a multipotent, stem cell-like state. Here, we identify Lola as a transcription factor that is required to maintain neurons in a differentiated state. We show that Lola represses neural stem cell genes and cell-cycle genes in postmitotic neurons. In lola mutants, neurons dedifferentiate, turn on neural stem cell genes, and begin to divide, forming tumors. Thus, neurons rather than stem cells or intermediate progenitors are the tumor-initiating cells in lola mutants.

Research Organization:: Univ. of Cambridge (United Kingdom)

Sponsoring Organization:: Wellcome Trust

OSTI ID:: 1623658

Journal Information:: Developmental Cell, Journal Name: Developmental Cell Journal Issue: 6 Vol. 28; ISSN 1534-5807

Publisher:: Cell Press - Elsevier

Country of Publication:: United States

Language:: English

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