The transcriptional regulator c2h2 accelerates mushroom formation in Agaricus bisporus

Pelkmans, Jordi F.; Vos, Aurin M.; Scholtmeijer, Karin; Hendrix, Ed; Baars, Johan J.  P.; Gehrmann, Thies; Reinders, Marcel J.  T.; Lugones, Luis G.; Wösten, Han A.  B.

doi:10.1007/s00253-016-7574-9

Title: The transcriptional regulator c2h2 accelerates mushroom formation in Agaricus bisporus

Journal Article · Sat May 21 00:00:00 EDT 2016 · Applied Microbiology and Biotechnology

DOI:https://doi.org/10.1007/s00253-016-7574-9· OSTI ID:1623596

Pelkmans, Jordi F. ^[1]; Vos, Aurin M. ^[1]; Scholtmeijer, Karin ^[2]; Hendrix, Ed ^[3]; Baars, Johan J. P. ^[3]; Gehrmann, Thies ^[4]; Reinders, Marcel J. T. ^[4]; Lugones, Luis G. ^[1]; Wösten, Han A. B. ^[1]

Univ. of Utrecht (Netherlands). Dept. of Biology. Microbiology
Univ. of Utrecht (Netherlands). Dept. of Biology. Microbiology; Wageningen Univ. and Research Centre (Netherlands). Plant Breeding
Wageningen Univ. and Research Centre (Netherlands). Plant Breeding
Delft Univ. of Technology (Netherlands). Delft Bioinformatics Lab

The Cys2His2 zinc finger protein gene c2h2 of Schizophyllum commune is involved in mushroom formation. Its inactivation results in a strain that is arrested at the stage of aggregate formation. In this study, the c2h2 orthologue of Agaricus bisporus was over-expressed in this white button mushroom forming basidiomycete using Agrobacterium-mediated transformation. Morphology, cap expansion rate, and total number and biomass of mushrooms were not affected by overexpression of c2h2. However, yield per day of the c2h2 overexpression strains peaked 1 day earlier. These data and expression analysis indicate that C2H2 impacts timing of mushroom formation at an early stage of development, making its encoding gene a target for breeding of commercial mushroom strains.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1623596

Journal Information:: Applied Microbiology and Biotechnology, Vol. 100, Issue 16; ISSN 0175-7598

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

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Transcription factors of Schizophyllum commune involved in mushroom formation and modulation of vegetative growth Pelkmans, Jordi F.; Patil, Mohini B.; Gehrmann, Thies Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/s41598-017-00483-3	journal	March 2017
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Nucleus-specific expression in the multinuclear mushroom-forming fungus Agaricus bisporus reveals different nuclear regulatory programs Gehrmann, Thies; Pelkmans, Jordi F.; Ohm, Robin A. Proceedings of the National Academy of Sciences, Vol. 115, Issue 17 https://doi.org/10.1073/pnas.1721381115	journal	April 2018
Transcriptomic atlas of mushroom development reveals conserved genes behind complex multicellularity in fungi Krizsán, Krisztina; Almási, Éva; Merényi, Zsolt Proceedings of the National Academy of Sciences, Vol. 116, Issue 15 https://doi.org/10.1073/pnas.1817822116	journal	March 2019
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H2O2 as a candidate bottleneck for MnP activity during cultivation of Agaricus bisporus in compost Vos, Aurin M.; Jurak, Edita; Pelkmans, Jordi F. AMB Express, Vol. 7, Issue 1 https://doi.org/10.1186/s13568-017-0424-z	journal	June 2017
Production of α-1,3-L-arabinofuranosidase active on substituted xylan does not improve compost degradation by Agaricus bisporus Vos, Aurin M.; Jurak, Edita; de Gijsel, Peter PLOS ONE, Vol. 13, Issue 7 https://doi.org/10.1371/journal.pone.0201090	journal	July 2018
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Highly efficient transformation system for Malassezia furfur and Malassezia pachydermatis using Agrobacterium tumefaciens-mediated transformation Celis, A. M.; Vos, A. M.; Triana, S. Journal of Microbiological Methods, Vol. 134 https://doi.org/10.1016/j.mimet.2017.01.001	journal	March 2017
Variants in RNA-Seq data show a continued mutation rate during strain preservation of Schizophyllum commune Gehrmann, Thies; Pelkmans, Jordi F.; Lugones, Luis G. BioRxiv https://doi.org/10.1101/201012	journal	October 2017
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59 BASIC BIOLOGICAL SCIENCES
Biotechnology & Applied Microbiology
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Agricus bisporus
Mushroom
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Cys2His2

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