High-resolution phase-contrast imaging of biological specimens using a stable betatron X-ray source in the multiple-exposure mode

Guo, Bo; Zhang, Xiaohui; Zhang, Jie; Hua, Jianfei; Pai, Chih-Hao; Zhang, Chaojie; Chu, Hsu-Hsin; Mori, Warren; Joshi, Chan; Wang, Jyhpyng; Lu, Wei

doi:10.1038/s41598-019-42834-2

Title: High-resolution phase-contrast imaging of biological specimens using a stable betatron X-ray source in the multiple-exposure mode

Journal Article · Fri May 24 00:00:00 EDT 2019 · Scientific Reports

DOI:https://doi.org/10.1038/s41598-019-42834-2· OSTI ID:1619639

Guo, Bo; Zhang, Xiaohui; Zhang, Jie; Hua, Jianfei; Pai, Chih-Hao; Zhang, Chaojie;

; Mori, Warren; Joshi, Chan; Wang, Jyhpyng; Lu, Wei

Abstract Phase-contrast imaging using X-ray sources with high spatial coherence is an emerging tool in biology and material science. Much of this research is being done using large synchrotron facilities or relatively low-flux microfocus X-ray tubes. An alternative high-flux, ultra-short and high-spatial-coherence table-top X-ray source based on betatron motions of electrons in laser wakefield accelerators has the promise to produce high quality images. In previous phase-contrast imaging studies with betatron sources, single-exposure images with a spatial resolution of 6–70 μ m were reported by using large-scale laser systems (60–200 TW). Furthermore, images obtained with multiple exposures tended to have a reduced contrast and resolution due to the shot-to-shot fluctuations. In this article, we demonstrate that a highly stable multiple-exposure betatron source, with an effective average source size of 5 μ m, photon number and pointing jitters of <5% and spectral fluctuation of <10%, can be obtained by utilizing ionization injection in pure nitrogen plasma using a 30–40 TW laser. Using this source, high quality phase-contrast images of biological specimens with a 5- μ m resolution are obtained for the first time. This work shows a way for the application of high resolution phase-contrast imaging with stable betatron sources using modest power, high repetition-rate lasers.

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Research Organization:: Univ. of California, Los Angeles, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: SC0008491; SC0008316; SC0010064

OSTI ID:: 1619639

Alternate ID(s):: OSTI ID: 1611033

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Vol. 9 Journal Issue: 1; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Cited by: 13 works

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