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Title: ARAS: an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes

Journal Article · · EJNMMI Research
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Automated protocols for measuring and dispensing solutions containing radioisotopes are essential not only for providing a safe environment for radiation workers but also to ensure accuracy of dispensed radioactivity and an efficient workflow. For this purpose, we have designed ARAS, an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes with particular focus on fluorine-18 (18F). The key to the system is the combination of a radiation detector measuring radioactivity concentration, in line with a peristaltic pump dispensing known volumes. Results show the combined system demonstrates volume variation to be within 5 % for dispensing volumes of 20 μL or greater. When considering volumes of 20 μL or greater, the delivered radioactivity is in agreement with the requested amount as measured independently with a dose calibrator to within 2 % on average. In conclusion, the integration of the detector and pump in an in-line system leads to a flexible and compact approach that can accurately dispense solutions containing radioactivity concentrations ranging from the high values typical of [18F]fluoride directly produced from a cyclotron (~0.1-1 mCi μL-1) to the low values typical of batches of [18F]fluoride-labeled radiotracers intended for preclinical mouse scans (~1-10 μCi μL-1).

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
Grant/Contract Number:
SC0001249; R25T CA098010
OSTI ID:
1619333
Alternate ID(s):
OSTI ID: 1259519
Journal Information:
EJNMMI Research, Journal Name: EJNMMI Research Vol. 6 Journal Issue: 1; ISSN 2191-219X
Publisher:
Springer Science + Business MediaCopyright Statement
Country of Publication:
Germany
Language:
English
Citation Metrics:
Cited by: 4 works
Citation information provided by
Web of Science

References (5)

The introduction of automated dispensing and injection during PET procedures: a step in the optimisation of extremity doses and whole-body doses of nuclear medicine staff journal March 2010
Multimodality Rodent Imaging Chambers for Use Under Barrier Conditions with Gas Anesthesia journal August 2008
Extremity doses of nuclear medicine personnel: a concern journal November 2011
Validation of a new protocol for 18F-FDG infusion using an automatic combined dispenser and injector system journal June 2012
A semi-automated vascular access system for preclinical models journal July 2013

Cited By (1)

Microfluidic radiobioassays: a radiometric detection tool for understanding cellular physiology and pharmacokinetics journal January 2019

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