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Title: Molecular clock of HIV-1 envelope genes under early immune selection

Journal Article · · Retrovirology
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Here, the molecular clock hypothesis that genes or proteins evolve at a constant rate is a key tool to reveal phylogenetic relationships among species. Using the molecular clock, we can trace an infection back to transmission using HIV-1 sequences from a single time point. Whether or not a strict molecular clock applies to HIV-1’s early evolution in the presence of immune selection has not yet been fully examined.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE; Work for Others (WFO)
Grant/Contract Number:
AC52-06NA25396
OSTI ID:
1618902
Alternate ID(s):
OSTI ID: 1321764
Report Number(s):
LA-UR-15-25156; 38; PII: 269
Journal Information:
Retrovirology, Journal Name: Retrovirology Vol. 13 Journal Issue: 1; ISSN 1742-4690
Publisher:
Springer Science + Business MediaCopyright Statement
Country of Publication:
United Kingdom
Language:
English
Citation Metrics:
Cited by: 6 works
Citation information provided by
Web of Science

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Cited By (1)

Recent advances in understanding HIV evolution journal January 2017

Linked Research (4)

Figures / Tables (7)

Fig. 1(p. 4)figure Fig. 1
Table 1(p. 4)table Table 1
Fig. 2(p. 5)figure Fig. 2
Fig. 3(p. 6)figure Fig. 3
Fig. 4(p. 7)figure Fig. 4
Table 2(p. 8)table Table 2
Fig. 5(p. 9)figure Fig. 5

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59 BASIC BIOLOGICAL SCIENCES
biological science
HIV-1
envelope gene
molecular clock
mathematical model