A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism

Cooper, Elizabeth A.; Brenton, Zachary W.; Flinn, Barry S.; Jenkins, Jerry; Shu, Shengqiang; Flowers, Dave; Luo, Feng; Wang, Yunsheng; Xia, Penny; Barry, Kerrie; Daum, Chris; Lipzen, Anna; Yoshinaga, Yuko; Schmutz, Jeremy; Saski, Christopher; Vermerris, Wilfred; Kresovich, Stephen

doi:10.1186/s12864-019-5734-x

Title: A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism

Journal Article · Mon May 27 00:00:00 EDT 2019 · BMC Genomics

DOI:https://doi.org/10.1186/s12864-019-5734-x· OSTI ID:1618572

; Brenton, Zachary W.; Flinn, Barry S.; Jenkins, Jerry; Shu, Shengqiang; Flowers, Dave; Luo, Feng; Wang, Yunsheng; Xia, Penny; Barry, Kerrie; Daum, Chris; Lipzen, Anna; Yoshinaga, Yuko; Schmutz, Jeremy; Saski, Christopher; Vermerris, Wilfred; Kresovich, Stephen

BACKGROUND:The process of crop domestication often consists of two stages: initial domestication, where the wild species is first cultivated by humans, followed by diversification, when the domesticated species are subsequently adapted to more environments and specialized uses. Selective pressure to increase sugar accumulation in certain varieties of the cereal crop Sorghum bicolor is an excellent example of the latter; this has resulted in pronounced phenotypic divergence between sweet and grain-type sorghums, but the genetic mechanisms underlying these differences remain poorly understood. RESULTS:Here we present a new reference genome based on an archetypal sweet sorghum line and compare it to the current grain sorghum reference, revealing a high rate of nonsynonymous and potential loss of function mutations, but few changes in gene content or overall genome structure. We also use comparative transcriptomics to highlight changes in gene expression correlated with high stalk sugar content and show that changes in the activity and possibly localization of transporters, along with the timing of sugar metabolism play a critical role in the sweet phenotype. CONCLUSIONS:The high level of genomic similarity between sweet and grain sorghum reflects their historical relatedness, rather than their current phenotypic differences, but we find key changes in signaling molecules and transcriptional regulators that represent new candidates for understanding and improving sugar metabolism in this important crop.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: FG02-07ER64458; AC02-05CH11231; AR0000595

OSTI ID:: 1618572

Alternate ID(s):: OSTI ID: 1572011

Journal Information:: BMC Genomics, Journal Name: BMC Genomics Vol. 20 Journal Issue: 1; ISSN 1471-2164

Publisher:: Springer Science + Business MediaCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Cited by: 42 works

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References (52)

The sorghum SWEET gene family: stem sucrose accumulation as revealed through transcriptome profiling Mizuno, Hiroshi; Kasuga, Shigemitsu; Kawahigashi, Hiroyuki Biotechnology for Biofuels, Vol. 9, Issue 1 https://doi.org/10.1186/s13068-016-0546-6	journal	June 2016
The Sorghum bicolor genome and the diversification of grasses Paterson, Andrew H.; Bowers, John E.; Bruggmann, Rémy Nature, Vol. 457, Issue 7229 https://doi.org/10.1038/nature07723	journal	January 2009
MATH/BTB CRL3 Receptors Target the Homeodomain-Leucine Zipper ATHB6 to Modulate Abscisic Acid Signaling Lechner, E.; Leonhardt, N.; Eisler, H. Developmental Cell, Vol. 21, Issue 6 https://doi.org/10.1016/j.devcel.2011.10.018	journal	December 2011
Versatile and open software for comparing large genomes Kurtz, Stefan; Phillippy, Adam; Delcher, Arthur L. Genome Biology, Vol. 5, Issue 2, R12 https://doi.org/10.1186/gb-2004-5-2-r12	journal	January 2004
A sorghum NAC gene is associated with variation in biomass properties and yield potential Xia, Jingnu; Zhao, Yunjun; Burks, Payne Plant Direct, Vol. 2, Issue 7 https://doi.org/10.1002/pld3.70	journal	July 2018
Alterations in stem sugar content and metabolism in sorghum genotypes subjected to drought stress Qazi, Hilal A.; Srinivasa Rao, Pinnamaneni; Kashikar, Akanksha Functional Plant Biology, Vol. 41, Issue 9 https://doi.org/10.1071/FP13299	journal	January 2014
BLAT---The BLAST-Like Alignment Tool Kent, W. J. Genome Research, Vol. 12, Issue 4 https://doi.org/10.1101/gr.229202	journal	March 2002
Insights into the Maize Pan-Genome and Pan-Transcriptome Hirsch, Candice N.; Foerster, Jillian M.; Johnson, James M. The Plant Cell, Vol. 26, Issue 1 https://doi.org/10.1105/tpc.113.119982	journal	January 2014
Genome-wide patterns of genetic variation in sweet and grain sorghum (Sorghum bicolor) Zheng, Lei-Ying; Guo, Xiao-Sen; He, Bing Genome Biology, Vol. 12, Issue 11 https://doi.org/10.1186/gb-2011-12-11-r114	journal	January 2011
SWEETs, transporters for intracellular and intercellular sugar translocation Eom, Joon-Seob; Chen, Li-Qing; Sosso, Davide Current Opinion in Plant Biology, Vol. 25 https://doi.org/10.1016/j.pbi.2015.04.005	journal	June 2015
MYB transcription factor genes as regulators for plant responses: an overview Ambawat, Supriya; Sharma, Poonam; Yadav, Neelam R. Physiology and Molecular Biology of Plants, Vol. 19, Issue 3 https://doi.org/10.1007/s12298-013-0179-1	journal	April 2013
Nonhybrid, finished microbial genome assemblies from long-read SMRT sequencing data Chin, Chen-Shan; Alexander, David H.; Marks, Patrick Nature Methods, Vol. 10, Issue 6 https://doi.org/10.1038/nmeth.2474	journal	May 2013
The Sorghum bicolor reference genome: improved assembly, gene annotations, a transcriptome atlas, and signatures of genome organization McCormick, Ryan F.; Truong, Sandra K.; Sreedasyam, Avinash The Plant Journal, Vol. 93, Issue 2 https://doi.org/10.1111/tpj.13781	journal	December 2017
Targeted analysis of nucleotide and copy number variation by exon capture in allotetraploid wheat genome Saintenac, Cyrille; Jiang, Dayou; Akhunov, Eduard D. Genome Biology, Vol. 12, Issue 9 https://doi.org/10.1186/gb-2011-12-9-r88	journal	January 2011
TopHat: discovering splice junctions with RNA-Seq Trapnell, Cole; Pachter, Lior; Salzberg, Steven L. Bioinformatics, Vol. 25, Issue 9 https://doi.org/10.1093/bioinformatics/btp120	journal	March 2009
Trimmomatic: a flexible trimmer for Illumina sequence data Bolger, Anthony M.; Lohse, Marc; Usadel, Bjoern Bioinformatics, Vol. 30, Issue 15 https://doi.org/10.1093/bioinformatics/btu170	journal	April 2014
Genetic Diversity among Sorghum Races and Working Groups Based on AFLPs and SSRs Perumal, Ramasamy; Krishnaramanujam, Renganayaki; Menz, Monica A. Crop Science, Vol. 47, Issue 4 https://doi.org/10.2135/cropsci2006.08.0532	journal	January 2007
Assemblytics: a web analytics tool for the detection of variants from an assembly Nattestad, Maria; Schatz, Michael C. Bioinformatics, Vol. 32, Issue 19 https://doi.org/10.1093/bioinformatics/btw369	journal	June 2016
Thinking outside the F-box: novel ligands for novel receptors Somers, David E.; Fujiwara, Sumire Trends in Plant Science, Vol. 14, Issue 4 https://doi.org/10.1016/j.tplants.2009.01.003	journal	April 2009
Are sucrose transporter expression profiles linked with patterns of biomass partitioning in Sorghum phenotypes? Milne, Ricky J.; Byrt, Caitlin S.; Patrick, John W. Frontiers in Plant Science, Vol. 4 https://doi.org/10.3389/fpls.2013.00223	journal	January 2013
Sucrose accumulation in sweet sorghum stems occurs by apoplasmic phloem unloading and does not involve differential Sucrose transporter expression Bihmidine, Saadia; Baker, R. Frank; Hoffner, Cassandra BMC Plant Biology, Vol. 15, Issue 1 https://doi.org/10.1186/s12870-015-0572-8	journal	July 2015
Screen of Genes Linked to High-Sugar Content in Stems by Comparative Genomics Calviño, Martín; Bruggmann, Rémy; Messing, Joachim Rice, Vol. 1, Issue 2 https://doi.org/10.1007/s12284-008-9012-9	journal	September 2008
EBSeq-HMM: a Bayesian approach for identifying gene-expression changes in ordered RNA-seq experiments Leng, Ning; Li, Yuan; McIntosh, Brian E. Bioinformatics, Vol. 31, Issue 16 https://doi.org/10.1093/bioinformatics/btv193	journal	April 2015
The plasticity of NBS resistance genes in sorghum is driven by multiple evolutionary processes Mace, Emma; Tai, Shuaishuai; Innes, David BMC Plant Biology, Vol. 14, Issue 1 https://doi.org/10.1186/s12870-014-0253-z	journal	September 2014
Early evolution of bHLH proteins in plants Pires, Nuno; Dolan, Liam Plant Signaling & Behavior, Vol. 5, Issue 7 https://doi.org/10.4161/psb.5.7.12100	journal	July 2010
Tonoplast Sugar Transporters (SbTSTs) putatively control sucrose accumulation in sweet sorghum stems Bihmidine, Saadia; Julius, Benjamin T.; Dweikat, Ismail Plant Signaling & Behavior, Vol. 11, Issue 1 https://doi.org/10.1080/15592324.2015.1117721	journal	January 2016
Compartmentation of sucrose during radial transfer in mature sorghum culm Tarpley, Lee; Vietor, Donald M. BMC Plant Biology, Vol. 7, Issue 1 https://doi.org/10.1186/1471-2229-7-33	journal	January 2007
Population genomic and genome-wide association studies of agroclimatic traits in sorghum Morris, G. P.; Ramu, P.; Deshpande, S. P. Proceedings of the National Academy of Sciences, Vol. 110, Issue 2 https://doi.org/10.1073/pnas.1215985110	journal	December 2012
QTLs for Energy-related Traits in a Sweet × Grain Sorghum [ (L.) Moench] Mapping Population Felderhoff, T. J.; Murray, S. C.; Klein, P. E. Crop Science, Vol. 52, Issue 5 https://doi.org/10.2135/cropsci2011.11.0618	journal	January 2012
Genome structural variation discovery and genotyping Alkan, Can; Coe, Bradley P.; Eichler, Evan E. Nature Reviews Genetics, Vol. 12, Issue 5 https://doi.org/10.1038/nrg2958	journal	March 2011
Assessment of genetic diversity in the sorghum reference set using EST-SSR markers Ramu, P.; Billot, C.; Rami, J-F. Theoretical and Applied Genetics, Vol. 126, Issue 8 https://doi.org/10.1007/s00122-013-2117-6	journal	May 2013
Arabidopsis thaliana proteins related to the yeast SIP and SNF4 interact with AKINalpha1, an SNF1-like protein kinase Bouly, Jean-Pierre; Gissot, Lionel; Lessard, Philippe The Plant Journal, Vol. 18, Issue 5 https://doi.org/10.1046/j.1365-313X.1999.00476.x	journal	June 1999
HTSeq--a Python framework to work with high-throughput sequencing data Anders, S.; Pyl, P. T.; Huber, W. Bioinformatics, Vol. 31, Issue 2 https://doi.org/10.1093/bioinformatics/btu638	journal	September 2014
Genetic Improvement of Sorghum as a Biofuel Feedstock: I. QTL for Stem Sugar and Grain Nonstructural Carbohydrates Murray, Seth C.; Sharma, Arun; Rooney, William L. Crop Science, Vol. 48, Issue 6 https://doi.org/10.2135/cropsci2008.01.0016	journal	January 2008
Phased diploid genome assembly with single-molecule real-time sequencing Chin, Chen-Shan; Peluso, Paul; Sedlazeck, Fritz J. Nature Methods, Vol. 13, Issue 12 https://doi.org/10.1038/nmeth.4035	journal	October 2016
Improved scoring of functional groups from gene expression data by decorrelating GO graph structure Alexa, A.; Rahnenfuhrer, J.; Lengauer, T. Bioinformatics, Vol. 22, Issue 13 https://doi.org/10.1093/bioinformatics/btl140	journal	April 2006
Arabidopsis BPM Proteins Function as Substrate Adaptors to a CULLIN3-Based E3 Ligase to Affect Fatty Acid Metabolism in Plants Chen, L.; Lee, J. H.; Weber, H. The Plant Cell, Vol. 25, Issue 6 https://doi.org/10.1105/tpc.112.107292	journal	June 2013
Plant F-Box Protein Evolution Is Determined by Lineage-Specific Timing of Major Gene Family Expansion Waves Navarro-Quezada, Aura; Schumann, Nadine; Quint, Marcel PLoS ONE, Vol. 8, Issue 7 https://doi.org/10.1371/journal.pone.0068672	journal	July 2013
Multifunctional Microtubule-Associated Proteins in Plants Krtková, Jana; Benáková, Martina; Schwarzerová, Kateřina Frontiers in Plant Science, Vol. 7 https://doi.org/10.3389/fpls.2016.00474	journal	April 2016
Fast gapped-read alignment with Bowtie 2 Langmead, Ben; Salzberg, Steven L. Nature Methods, Vol. 9, Issue 4 https://doi.org/10.1038/nmeth.1923	journal	March 2012
A general method applicable to the search for similarities in the amino acid sequence of two proteins Needleman, Saul B.; Wunsch, Christian D. Journal of Molecular Biology, Vol. 48, Issue 3, p. 443-453 https://doi.org/10.1016/0022-2836(70)90057-4	journal	March 1970
Internodal Compartmentation of Stem-Infused [14C]Sucrose in Sweet and Grain Sorghum Tarpley, Lee; Vietor, Donald M.; Miller, Frederick R. Crop Science, Vol. 34, Issue 4 https://doi.org/10.2135/cropsci1994.0011183X003400040052x	journal	January 1994
A Simplified Classification of Cultivated Sorghum1 Harlan, J. R.; de Wet, J. M. J. Crop Science, Vol. 12, Issue 2 https://doi.org/10.2135/cropsci1972.0011183X001200020005x	journal	January 1972
Genomes of 13 domesticated and wild rice relatives highlight genetic conservation, turnover and innovation across the genus Oryza Stein, Joshua C.; Yu, Yeisoo; Copetti, Dario Nature Genetics, Vol. 50, Issue 2 https://doi.org/10.1038/s41588-018-0040-0	journal	January 2018
Stem sugar accumulation in sweet sorghum – Activity and expression of sucrose metabolizing enzymes and sucrose transporters Qazi, Hilal Ahmad; Paranjpe, Sharayu; Bhargava, Sujata Journal of Plant Physiology, Vol. 169, Issue 6 https://doi.org/10.1016/j.jplph.2012.01.005	journal	April 2012
Improving the Arabidopsis genome annotation using maximal transcript alignment assemblies Haas, B. J. Nucleic Acids Research, Vol. 31, Issue 19 https://doi.org/10.1093/nar/gkg770	journal	October 2003
The Sequence Alignment/Map format and SAMtools Li, H.; Handsaker, B.; Wysoker, A. Bioinformatics, Vol. 25, Issue 16 https://doi.org/10.1093/bioinformatics/btp352	journal	June 2009
Cytochromes P450 Bak, Søren; Beisson, Fred; Bishop, Gerard The Arabidopsis Book, Vol. 9 https://doi.org/10.1199/tab.0144	journal	January 2011
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 Love, Michael I.; Huber, Wolfgang; Anders, Simon Genome Biology, Vol. 15, Issue 12 https://doi.org/10.1186/s13059-014-0550-8	journal	December 2014
Community Resources and Strategies for Association Mapping in Sorghum Casa, Alexandra M.; Pressoir, Gael; Brown, Patrick J. Crop Science, Vol. 48, Issue 1 https://doi.org/10.2135/cropsci2007.02.0080	journal	January 2008
Genome-wide copy number variations in Oryza sativa L. Yu, Ping; Wang, Cai-Hong; Xu, Qun BMC Genomics, Vol. 14, Issue 1 https://doi.org/10.1186/1471-2164-14-649	journal	January 2013
A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w Cingolani, Pablo; Platts, Adrian; Wang, Le Lily Fly, Vol. 6, Issue 2 https://doi.org/10.4161/fly.19695	journal	April 2012

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Additional file 10: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190719 The current record is supplemented by this dataset	dataset	January 2019
Additional file 10: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190719.v1 The current record is supplemented by this dataset	dataset	January 2019
Additional file 1: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190728 The current record is supplemented by this text	text	January 2019
Additional file 1: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190728.v1 The current record is supplemented by this text	text	January 2019
Additional file 2: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190734 The current record is supplemented by this text	text	January 2019
Additional file 2: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190734.v1 The current record is supplemented by this text	text	January 2019
Additional file 3: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190740 The current record is supplemented by this dataset	dataset	January 2019
Additional file 3: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190740.v1 The current record is supplemented by this dataset	dataset	January 2019
Additional file 4: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190743 The current record is supplemented by this dataset	dataset	January 2019
Additional file 4: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190743.v1 The current record is supplemented by this dataset	dataset	January 2019
Additional file 5: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190749 The current record is supplemented by this dataset	dataset	January 2019
Additional file 5: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190749.v1 The current record is supplemented by this dataset	dataset	January 2019
Additional file 6: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190755 The current record is supplemented by this dataset	dataset	January 2019
Additional file 6: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190755.v1 The current record is supplemented by this dataset	dataset	January 2019
Additional file 7: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190758 The current record is supplemented by this dataset	dataset	January 2019
Additional file 7: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190758.v1 The current record is supplemented by this dataset	dataset	January 2019
Additional file 8: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190764 The current record is supplemented by this dataset	dataset	January 2019
Additional file 8: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190764.v1 The current record is supplemented by this dataset	dataset	January 2019
Additional file 9: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190776 The current record is supplemented by this dataset	dataset	January 2019
Additional file 9: of A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.8190776.v1 The current record is supplemented by this dataset	dataset	January 2019
A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.c.4519544 The current record is supplemented by this collection	collection	January 2019
A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism Cooper, Elizabeth; Brenton, Zachary; Flinn, Barry https://doi.org/10.6084/m9.figshare.c.4519544.v1 The current record is supplemented by this collection	collection	January 2019

Title: A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism

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