Proteome Remodeling in Response to Sulfur Limitation in “ Candidatus Pelagibacter ubique”

Smith, Daniel P.; Nicora, Carrie D.; Carini, Paul; Lipton, Mary S.; Norbeck, Angela D.; Smith, Richard D.; Giovannoni, Stephen J.; Wilmes, ed., Paul

doi:10.1128/mSystems.00068-16

Proteome Remodeling in Response to Sulfur Limitation in “ Candidatus Pelagibacter ubique”

Journal Article · Tue Aug 30 00:00:00 EDT 2016 · mSystems

DOI:https://doi.org/10.1128/mSystems.00068-16· OSTI ID:1618364

Smith, Daniel P. ^[1]; Nicora, Carrie D. ^[2]; Carini, Paul ^[1]; Lipton, Mary S. ^[2]; Norbeck, Angela D. ^[2]; Smith, Richard D. ^[2]; Giovannoni, Stephen J. ^[1]; Wilmes, ed., Paul

Department of Microbiology, Oregon State University, Corvallis, Oregon, USA
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA

“ Ca . Pelagibacter ubique” is a key driver of marine biogeochemistry cycles and a model for understanding how minimal genomes evolved in free-living anucleate organisms. This study explores the unusual sulfur acquisition strategy that has evolved in these cells, which lack assimilatory sulfate reduction and instead rely on reduced sulfur compounds found in oxic marine environments to meet their cellular quotas. Our findings demonstrate that the sulfur acquisition systems are constitutively expressed but the enzymatic steps leading to the essential sulfur-containing amino acid methionine are regulated by a unique array of riboswitches and genes, many of which are encoded in a rapidly evolving genome region. These findings support mounting evidence that streamlined cells have evolved regulatory mechanisms that minimize transcriptional switching and, unexpectedly, localize essential sulfur acquisition genes in a genome region normally associated with adaption to environmental variation.

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Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1618364

Alternate ID(s):: OSTI ID: 1342322

Journal Information:: mSystems, Journal Name: mSystems Journal Issue: 4 Vol. 1; ISSN 2379-5077

Publisher:: American Society for MicrobiologyCopyright Statement

Country of Publication:: United States

Language:: English

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