Steps towards ‘drop-in’ biofuels: focusing on metabolic pathways

Jiang, Wen; Gu, Pengfei; Zhang, Fuzhong

doi:10.1016/j.copbio.2017.10.010

Steps towards ‘drop-in’ biofuels: focusing on metabolic pathways

Journal Article · Tue Dec 05 04:00:00 EST 2017 · Current Opinion in Biotechnology

DOI:https://doi.org/10.1016/j.copbio.2017.10.010· OSTI ID:1612924

Jiang, Wen ^[1]; Gu, Pengfei ^[2]; Zhang, Fuzhong ^[2]

Washington Univ., St. Louis, MO (United States); DOE/OSTI
Washington Univ., St. Louis, MO (United States)

The past decade has witnessed rapid advance in microbial production of ‘drop-in’ biofuels from renewable resources. Various biosynthetic pathways have been constructed to produce biofuels with diverse structures, and multiple metabolic engineering strategies have been developed to increase biofuel titers, yields, productivities and system robustness. In this review, we intend to give a brief but comprehensive overview of the most recent progresses on four essential pathways leading to ‘drop-in’ biofuel production, with an emphasis on the metabolic pathway efficiencies and biofuel structures. Furthermore, we also provide an insightful discussion on optimization strategies to improve the robustness of the microbial platforms for biofuel production.

View Accepted Manuscript (DOE)

Research Organization:: Washington Univ., St. Louis, MO (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0018324

OSTI ID:: 1612924

Alternate ID(s):: OSTI ID: 1548916

Journal Information:: Current Opinion in Biotechnology, Journal Name: Current Opinion in Biotechnology Vol. 53; ISSN 0958-1669

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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