C–H 18F-fluorination of 8-methylquinolines with Ag[18F]F

Lee, So Jeong; Brooks, Allen F.; Ichiishi, Naoko; Makaravage, Katarina J.; Mossine, Andrew V.; Sanford, Melanie S.; Scott, Peter J. H.

doi:10.1039/c9cc00641a

C–H ¹⁸F-fluorination of 8-methylquinolines with Ag[¹⁸F]F

Journal Article · Tue Feb 12 00:00:00 EST 2019 · ChemComm

DOI:https://doi.org/10.1039/c9cc00641a· OSTI ID:1611829

^[1]; ^[2]; Ichiishi, Naoko ^[3]; ^[3]; ^[2]; ^[3]; ^[2]

Univ. of Michigan, Ann Arbor, MI (United States). Dept. of Radiology; DOE/OSTI
Univ. of Michigan, Ann Arbor, MI (United States). Dept. of Radiology
Univ. of Michigan, Ann Arbor, MI (United States). Dept. of Chemistry

This report describes a Pd-mediated C–H radiofluorination of 8-methylquinoline derivatives with no-carrier-added Ag[¹⁸F]F. To achieve this transformation, a new method was developed for the generation of Ag[¹⁸F]F using a sep-pak cartridge. The C–H radiofluorination was then optimized and applied to a series of substituted 8-methylquinoline derivatives. Finally, this method was fully automated using a radiochemistry synthesis module.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of Michigan, Ann Arbor, MI (United States)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0012484

OSTI ID:: 1611829

Alternate ID(s):: OSTI ID: 1495071

Journal Information:: ChemComm, Journal Name: ChemComm Journal Issue: 20 Vol. 55; ISSN 1359-7345

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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