Holistic Approaches in Lipid Production by Yarrowia lipolytica

Lazar, Zbigniew; Liu, Nian; Stephanopoulos, Gregory

doi:10.1016/j.tibtech.2018.06.007

Holistic Approaches in Lipid Production by Yarrowia lipolytica

Journal Article · Wed Jul 11 00:00:00 EDT 2018 · Trends in Biotechnology

DOI:https://doi.org/10.1016/j.tibtech.2018.06.007· OSTI ID:1611149

Lazar, Zbigniew ^[1]; Liu, Nian ^[2]; Stephanopoulos, Gregory ^[2]

Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Wroclaw Univ. of Environmental and Life Sciences (Poland); DOE/OSTI
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

Concerns about climate change have driven research on the production of lipid-derived biofuels as an alternative and renewable liquid fuel source. Using oleaginous yeasts for lipid synthesis creates the potential for cost-effective industrial-scale operations due to their ability to reach high lipid titer, yield, and productivity resulting from their unique metabolism. Yarrowia lipolytica is the model oleaginous yeast, with the best-studied lipid metabolism, the greatest number of genetic tools, and a fully sequenced genome. In this review we highlight multiomics studies that elucidate the mechanisms allowing this yeast to achieve lipid overaccumulation and then present several major metabolic engineering efforts that enhanced the production metrics in Y. lipolytica. Recent achievements that applied novel engineering strategies are emphasized.

View Accepted Manuscript (DOE)

Research Organization:: Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0008744

OSTI ID:: 1611149

Journal Information:: Trends in Biotechnology, Journal Name: Trends in Biotechnology Journal Issue: 11 Vol. 36; ISSN 0167-7799

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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