3D-Printed Hydrogel Composites for Predictive Temporal (4D) Cellular Organizations and Patterned Biogenic Mineralization

McCracken, Joselle M.; Rauzan, Brittany M.; Kjellman, Jacob C.  E.; Kandel, Mikhail E.; Liu, Yu Hao; Badea, Adina; Miller, Lou Ann; Rogers, Simon A.; Popescu, Gabriel; Nuzzo, Ralph G.

doi:10.1002/adhm.201800788

Title: 3D-Printed Hydrogel Composites for Predictive Temporal (4D) Cellular Organizations and Patterned Biogenic Mineralization

Journal Article · Thu Nov 22 00:00:00 EST 2018 · Advanced Healthcare Materials

DOI:https://doi.org/10.1002/adhm.201800788· OSTI ID:1607430

^[1]; Rauzan, Brittany M. ^[1]; Kjellman, Jacob C. E. ^[1];

^[2];

^[3];

^[1]; Miller, Lou Ann ^[4]; Rogers, Simon A. ^[1]; Popescu, Gabriel ^[2];

^[5]

Univ. of Illinois at Urbana-Champaign, IL (United States)
Beckman Institute, Urbana, IL (United States)
Univ. of Illinois at Urbana-Champaign, IL (United States). Frederick Seitz Materials Research Laboratory
Univ. of Illinois at Urbana-Champaign, IL (United States). Frederick Seitz Materials Research Laboratory and Department of Materials Science and Engineering
Univ. of Illinois at Urbana-Champaign, IL (United States). Frederick Seitz Materials Research Laboratory; KTH Royal Inst. of Technology, Stockholm (Sweden)

Abstract Materials chemistries for hydrogel scaffolds that are capable of programming temporal (4D) attributes of cellular decision‐making in supported 3D microcultures are described. The scaffolds are fabricated using direct‐ink writing (DIW)—a 3D‐printing technique using extrusion to pattern scaffolds at biologically relevant diameters (≤ 100 µm). Herein, DIW is exploited to variously incorporate a rheological nanoclay, Laponite XLG (LAP), into 2‐hydroxyethyl methacrylate (HEMA)‐based hydrogels—printing the LAP–HEMA (LH) composites as functional modifiers within otherwise unmodified 2D and 3D HEMA microstructures. The nanoclay‐modified domains, when tested as thin films, require no activating (e.g., protein) treatments to promote robust growth compliances that direct the spatial attachment of fibroblast (3T3) and preosteoblast (E1) cells, fostering for the latter a capacity to direct long‐term osteodifferentiation. Cell‐to‐gel interfacial morphologies and cellular motility are analyzed with spatial light interference microscopy (SLIM). Through combination of HEMA and LH gels, high‐resolution DIW of a nanocomposite ink (UniH) that translates organizationally dynamic attributes seen with 2D gels into dentition‐mimetic 3D scaffolds is demonstrated. These analyses confirm that the underlying materials chemistry and geometry of hydrogel nanocomposites are capable of directing cellular attachment and temporal development within 3D microcultures—a useful material system for the 4D patterning of hydrogel scaffolds.

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Research Organization:: Univ. of Illinois at Urbana-Champaign, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division; USDOE

Grant/Contract Number:: FG02-07ER46471; DE‐FG02‐07ER46471

OSTI ID:: 1607430

Alternate ID(s):: OSTI ID: 1488354

Journal Information:: Advanced Healthcare Materials, Vol. 8, Issue 1; ISSN 2192-2640

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 21 works

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