Thermoresponsive Stiffening with Microgel Particles in a Semiflexible Fibrin Network

Chaudhary, Gaurav; Ghosh, Ashesh; Bharadwaj, N. Ashwin; Kang, Jin Gu; Braun, Paul V.; Schweizer, Kenneth S.; Ewoldt, Randy H.

doi:10.1021/acs.macromol.9b00124

Thermoresponsive Stiffening with Microgel Particles in a Semiflexible Fibrin Network

Journal Article · Tue Apr 09 00:00:00 EDT 2019 · Macromolecules

DOI:https://doi.org/10.1021/acs.macromol.9b00124· OSTI ID:1606375

^[1]; Ghosh, Ashesh ^[2]; Bharadwaj, N. Ashwin ^[2]; Kang, Jin Gu ^[3]; ^[2]; Schweizer, Kenneth S. ^[2]; ^[2]

Univ. of Illinois at Urbana-Champaign, IL (United States); University of Illinois at Urbana-Champaign
Univ. of Illinois at Urbana-Champaign, IL (United States)
Univ. of Illinois at Urbana-Champaign, IL (United States); Korea Inst. of Science and Technology, Seoul (South Korea)

We report here temperature-responsive soft composites of semiflexible biopolymer networks (fibrin) containing dispersed microgel colloidal particles of poly(N-isopropylacrylamide) (pNIPAM) that undergo a thermodynamically driven deswelling transition above the lower critical solution temperature. Unlike standard polymer particle composites, decreasing the inclusion volume of the particles (by increasing temperature) is concomitant with a striking increase of the overall elastic stiffness of the composite. We observe such a behavior over a wide composition space. The composite elastic shear modulus reversibly stiffens by up to 10-fold over a small change in temperature from 25 to 35 °C. In isolation, the fibrin network and microgel suspension both soften with increased temperature, making the stiffening of the composites particularly significant. We hypothesize that stiffening is caused by the shrinking microgel particles that deform fibrin filaments, and modify the network structure. We further develop a phenomenological model that quantifies this hypothesis, and the derived predictions are qualitatively consistent with our experimental data.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of Illinois at Urbana-Champaign, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

Grant/Contract Number:: FG02-07ER46471

OSTI ID:: 1606375

Journal Information:: Macromolecules, Journal Name: Macromolecules Journal Issue: 8 Vol. 52; ISSN 0024-9297

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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