Metal–Organic Framework-Based Microfluidic Impedance Sensor Platform for Ultrasensitive Detection of Perfluorooctanesulfonate

Cheng, Yu H.; Barpaga, Dushyant; Soltis, Jennifer A.; Shutthanandan, V.; Kargupta, Roli; Han, Kee Sung; McGrail, B. Peter; Motkuri, Radha Kishan; Basuray, Sagnik; Chatterjee, Sayandev

doi:10.1021/acsami.9b22445

Title: Metal–Organic Framework-Based Microfluidic Impedance Sensor Platform for Ultrasensitive Detection of Perfluorooctanesulfonate

Journal Article · Fri Feb 07 00:00:00 EST 2020 · ACS Applied Materials and Interfaces

DOI:https://doi.org/10.1021/acsami.9b22445· OSTI ID:1605355

Cheng, Yu H. ^[1];

^[2]; Soltis, Jennifer A. ^[2];

^[2]; Kargupta, Roli ^[1];

^[2]; McGrail, B. Peter ^[2];

^[2]; Basuray, Sagnik ^[1];

^[2]

New Jersey Institute of Technology, Newark, NJ (United States)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

The growing global concerns to public health from human exposure to perfluorooctanesulfonate (PFOS) requires rapid, sensitive, in-situ detection where current, state-of-the-art techniques are yet to adequately meet sensitivity and selectivity standards of the real-world. This work presents, for the first time, a synergistic approach for the targeted affinity-based capture of PFOS using a porous sorbent probe that enhances detection sensitivity by embedding it on a microfluidic conductive platform. This novel sorbent-containing platform functions as an electrochemical sensor to directly measure PFOS concentration through a proportional change in electrical response (increase in impedance). The extremely high surface area and pore volume of mesoporous metal-organic framework (MOF) Cr-MIL-101 is used as the probe for targeted PFOS capture based on the affinity of the chromium center towards both the fluorine tail groups as well as the sulfonate functionalities as demonstrated by spectroscopic (NMR and XPS) and microscopic (TEM) studies. Answering the need for an ultrasensitive PFOS detection technique, we are embedding these MOF capture probes inside a microfluidic channel, sandwiched between interdigitated microelectrodes (IDµE). The nanoporous geometry increases the signal to noise ratio of interdigitated microelectrodes tremendously increasing sensitivity; this in combination with the ability of the capture probes to interact with the PFOS at the molecular level and effectively transduce that response electrochemically has allowed us achieve a PFOS detection limit of 0.5 ng/L, which is unprecedented for in-situ analytical PFOS sensors and even comparable to quantification limits achieved using state-of-the-art ex situ techniques.

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Research Organization:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1605355

Report Number(s):: PNNL-SA-141266

Journal Information:: ACS Applied Materials and Interfaces, Vol. 12, Issue 9; ISSN 1944-8244

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 42 works

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36 MATERIALS SCIENCE
metal−organic frameworks
microfluidics
impedance
perfluorooctanesulfonate
sensing
detection

Title: Metal–Organic Framework-Based Microfluidic Impedance Sensor Platform for Ultrasensitive Detection of Perfluorooctanesulfonate

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