Covalent Surface Modification Effects on Single‐Walled Carbon Nanotubes for Targeted Sensing and Optical Imaging

Chio, Linda; Pinals, Rebecca L.; Murali, Aishwarya; Goh, Natalie S.; Landry, Markita P.

doi:10.1002/adfm.201910556

Covalent Surface Modification Effects on Single‐Walled Carbon Nanotubes for Targeted Sensing and Optical Imaging

Journal Article · Wed Mar 04 00:00:00 EST 2020 · Advanced Functional Materials

DOI:https://doi.org/10.1002/adfm.201910556· OSTI ID:1602907

^[1]; Pinals, Rebecca L. ^[1]; Murali, Aishwarya ^[1]; Goh, Natalie S. ^[1]; Landry, Markita P. ^[2]

Department of Chemical and Biomolecular Engineering University of California, Berkeley Berkeley CA 94720 USA
Department of Chemical and Biomolecular Engineering University of California, Berkeley Berkeley CA 94720 USA, Chan‐Zuckerberg Biohub San Francisco CA 94158 USA, California Institute for Quantitative Biosciences (qb3) University of California, Berkeley Berkeley CA 94720 USA

Abstract

Optical nanoscale technologies often implement covalent or noncovalent strategies for the modification of nanoparticles, whereby both functionalizations are leveraged for multimodal applications but can affect the intrinsic fluorescence of nanoparticles. Specifically, single‐walled carbon nanotubes (SWCNTs) can enable real‐time imaging and cellular delivery; however, the introduction of covalent SWCNT sidewall functionalizations often attenuates SWCNT fluorescence. Recent advances in SWCNT covalent functionalization chemistries preserve the SWCNT's pristine graphitic lattice and intrinsic fluorescence, and here, such covalently functionalized SWCNTs maintain intrinsic fluorescence‐based molecular recognition of neurotransmitter and protein analytes. The covalently modified SWCNT nanosensor preserves its fluorescence response towards its analyte for certain nanosensors, presumably dependent on the intermolecular interactions between SWCNTs or the steric hindrance introduced by the covalent functionalization that hinders noncovalent interactions with the SWCNT surface. These SWCNT nanosensors are further functionalized via their covalent handles with a targeting ligand, biotin, to self‐assemble on passivated microscopy slides, and these dual‐functionalized SWCNT materials are explored for future use in multiplexed sensing and imaging applications.

View Accepted Manuscript (Publisher)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1602907

Journal Information:: Advanced Functional Materials, Journal Name: Advanced Functional Materials Journal Issue: 17 Vol. 30; ISSN 1616-301X

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

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