Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Closed fumarase C active;#8208;site structures reveal SS Loop residue contribution in catalysis

Journal Article · · FEBS Lett.
Abstract not provided
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - BASIC ENERGY SCIENCES
OSTI ID:
1600819
Journal Information:
FEBS Lett., Journal Name: FEBS Lett. Journal Issue: (2) ; 01, 2020 Vol. 594
Country of Publication:
United States
Language:
ENGLISH

References (71)

Structural studies on M. tuberculosis argininosuccinate lyase and its liganded complex: Insights into catalytic mechanism journal December 2018
Dynamic Requirements for a Functional Protein Hinge journal April 2007
Crystal Structure of 3-Carboxy- cis , cis -muconate Lactonizing Enzyme from Pseudomonas putida , a Fumarase Class II Type Cycloisomerase:  Enzyme Evolution in Parallel Pathways journal August 2004
Biochemical Characterization of Two Clinically-Relevant Human Fumarase Variants Defective for Oligomerization journal January 2018
Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site journal April 1997
The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway journal February 2000
Entropy Effects on Protein Hinges:  The Reaction Catalyzed by Triosephosphate Isomerase journal September 2004
Understanding Protein Lids:  Kinetic Analysis of Active Hinge Mutants in Triosephosphate Isomerase journal August 1999
Features and development of Coot journal March 2010
Spectrophotometric measurements of the enzymatic formation of fumaric and cis-aconitic acids journal January 1950
Missense Mutations in Fumarate Hydratase in Multiple Cutaneous and Uterine Leiomyomatosis and Renal Cell Cancer journal October 2005
Three-Dimensional Structure of the Argininosuccinate Lyase Frequently Complementing Allele Q286R , journal December 2001
Studies on fumarase. 2. The effects of inorganic anions on fumarase activity journal January 1953
Data processing and analysis with the autoPROC toolbox journal March 2011
Uterine smooth muscle tumors with features suggesting fumarate hydratase aberration: detailed morphologic analysis and correlation with S-(2-succino)-cysteine immunohistochemistry journal December 2013
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Dynamics of the active site loops in catalyzing aminoacylation reaction in seryl and histidyl t RNA synthetases journal March 2017
PROCHECK: a program to check the stereochemical quality of protein structures journal April 1993
Structural Comparison of the Enzymatically Active and Inactive Forms of δ Crystallin and the Role of Histidine 91 , journal November 1997
MolProbity : all-atom structure validation for macromolecular crystallography journal December 2009
The structure of avian eye lens δ-crystallin reveals a new fold for a superfamily of oligomeric enzymes journal October 1994
The multisubunit active site of fumarase C from Escherichia coli journal August 1995
Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis journal May 2012
Substrate and Product Complexes of Escherichia coli Adenylosuccinate Lyase Provide New Insights into the Enzymatic Mechanism journal July 2007
Metabolism of ketonic acids in animal tissues journal April 1937
Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis journal March 2005
Structure of free fumarase C from Escherichia coli journal September 2005
Structural and functional relationships between fumarase and aspartase. Nucleotide sequences of the fumarase (fumC) and aspartase (aspA) genes of Escherichia coli K12 journal July 1986
Crystal Structure of Thermostable Aspartase from Bacillus sp. YM55-1: Structure-based Exploration of Functional Sites in the Aspartase Family journal May 2003
Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site journal June 2016
The role of the allosteric B site in the fumarase reaction journal February 2004
Stereochemistry of polypeptide chain configurations journal July 1963
Fumarase A from Escherichia coli: purification and characterization as an iron-sulfur cluster containing enzyme journal October 1992
Restructuring the Active Site of Fumarase for the Fumarate to Malate Reaction journal October 1997
Oncometabolites: A New Paradigm for Oncology, Metabolism, and the Clinical Laboratory journal December 2017
Crystallographic Studies of the Catalytic and a Second Site in Fumarase C from Escherichia coli , journal January 1996
Mutational Analysis of Duck δ2 Crystallin and the Structure of an Inactive Mutant with Bound Substrate Provide Insight into the Enzymatic Mechanism of Argininosuccinate Lyase journal November 2001
Molecular Pathways: Fumarate Hydratase-Deficient Kidney Cancer--Targeting the Warburg Effect in Cancer journal April 2013
Potential genetic anticipation in hereditary leiomyomatosis-renal cell cancer (HLRCC) journal February 2014
Structural basis of fumarate hydratase deficiency journal March 2011
Genetic alterations in Krebs cycle and its impact on cancer pathogenesis journal April 2017
Role of conformational change in the fumarase reaction cycle journal August 1993
Aspartase/Fumarase Superfamily: A Common Catalytic Strategy Involving General Base-Catalyzed Formation of a Highly Stabilized aci - Carboxylate Intermediate journal May 2012
Perturbation of the Conformational Dynamics of an Active-Site Loop Alters Enzyme Activity journal December 2015
Crystal structures of native and recombinant yeast fumarase 1 1Edited by D. Rees journal July 1998
The PDB_REDO server for macromolecular structure model optimization journal May 2014
Mitochondrial dysfunctions in cancer: Genetic defects and oncogenic signaling impinging on TCA cycle activity journal January 2015
XDS journal January 2010
Use of isotope effects to deduce the chemical mechanism of fumarase journal September 1980
X-ray crystallographic and kinetic correlation of a clinically observed human fumarase mutation journal June 2002
Structure determination and refinement at 2.44 Å resolution of argininosuccinate lyase from Escherichia coli journal October 2004
How Fumarase Recycles after the Malate → Fumarate Reaction. Insights into the Reaction Mechanism journal December 1998
Controlling Active Site Loop Dynamics in the (β/α)8 Barrel Enzyme Indole-3-Glycerol Phosphate Synthase journal August 2016
KaleidaGraph:  Graphing and Data Analysis. Version 3.5 for Windows Synergy Software, 2457 Perkiomen Ave., Reading, PA 19606-2049. www.Synergy.com. $155.00 journal November 2000
How good are my data and what is the resolution? journal June 2013
Beyond active site residues: overall structural dynamics control catalysis in flavin-containing and heme-containing monooxygenases journal December 2019
Prolonged incubation in calcium chloride improves the competence of Escherichia coli cells journal January 1979
Fumarase deficiency: a rare disorder on the crossroads of clinical and metabolic genetics, neurology and cancer journal January 2017
Crystal Structure of an Inactive Duck δ II Crystallin Mutant with Bound Argininosuccinate , journal February 1999
Role of Asp102 in the Catalytic Relay System of Serine Proteases:  A Theoretical Study journal June 2004
Protein homology detection by HMM-HMM comparison journal November 2004
Cellular Proteomes Have Broad Distributions of Protein Stability journal December 2010
Connecting Active-Site Loop Conformations and Catalysis in Triosephosphate Isomerase: Insights from a Rare Variation at Residue 96 in the Plasmodial Enzyme journal February 2016
The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency journal March 2008
Structural Studies of Duck δ1 and δ2 Crystallin Suggest Conformational Changes Occur during Catalysis , journal March 2001
Studies on fumarase. 3. The effect of temperature journal January 1953
Fumarase: From the TCA Cycle to DNA Damage Response and Tumor Suppression journal July 2018
Two biochemically distinct classes of fumarase in Escherichia coli journal January 1988
Structural Basis for the Catalytic Mechanism of Aspartate Ammonia Lyase journal July 2011
Studies on fumarase. 4. The effects of inhibitors on fumarase activity journal August 1953
The Structure of l -Aspartate Ammonia-Lyase from Escherichia coli , journal July 1997

Similar Records

Crystal structure of a c;#8208;di;#8208;AMP riboswitch reveals an internally pseudo;#8208;dimeric RNA
Journal Article · Mon Nov 17 23:00:00 EST 2014 · EMBO J. · OSTI ID:1182789

Dynamics of an Active-Site Flap Contributes to Catalysis in a JAMM Family Metallo Deubiquitinase
Journal Article · Thu May 05 00:00:00 EDT 2016 · Biochemistry · OSTI ID:1227501

Contributions of Unique Active Site Residues of Eukaryotic UDP-Galactopyranose Mutases to Substrate Recognition and Active Site Dynamics
Journal Article · Mon Sep 14 00:00:00 EDT 2015 · Biochemistry-US · OSTI ID:1168508

Related Subjects