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Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette

Patent ·
OSTI ID:1600275
A self-shielded, bench-top radiochemistry system, including a radioactive isotope dispensing module configured to draw an isotope out of a vial and dispense one or more metered doses of the isotope to a concentration module that concentrates the metered dose into a droplet amount of isotope and a synthesizer module that delivers the droplet amount of isotope along with one or more reagents to an electrowetting on dielectrics (EWOD) chip to produce a radiolabeled molecule.
Research Organization:
Univ. of California, Oakland, CA (United States); Sofie Biosciences, Inc., Culver City, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
SC0006238
Assignee:
The Regents of the University of California (Oakland, CA); Sofie Biosciences, Inc. (Culver City, CA)
Patent Number(s):
10,473,668
Application Number:
15/315,369
OSTI ID:
1600275
Country of Publication:
United States
Language:
English

References (33)

Microfluidic reactions using [11C]carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer journal January 2011
Batch-reactor microfluidic device: first human use of a microfluidically produced PET radiotracer journal January 2013
Fluorocarbohydrates in synthesis. An efficient synthesis of 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil (.beta.-FIAU) and 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)thymine (.beta.-FMAU) journal September 1985
Semiautomated Radiosynthesis and Biological Evaluation of [18F]FEAU: A Novel PET Imaging Agent for HSV1-tk/sr39tk Reporter Gene Expression journal December 2007
EWOD Driving of Droplet on NxM Grid using Single-Layer Electrode Patterns conference June 2002
On-demand droplet loading for automated organic chemistry on digital microfluidics journal January 2013
Soft printing of droplets pre-metered by electrowetting journal September 2004
Plug-and-play modules for flexible radiosynthesis journal August 2013
Synthesis of [18F]-labeled 2?-deoxy-2?-fluoro-5-methyl-1-?-D-arabinofuranosyluracil ([18F]-FMAU)
  • Alauddin, Mian M.; Conti, Peter S.; Fissekis, John D.
  • Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 45, Issue 7 https://doi.org/10.1002/jlcr.549
journal January 2002
Microreactors for radiopharmaceutical synthesis journal January 2009
World-to-Digital-Microfluidic Interface Enabling Extraction and Purification of RNA from Human Whole Blood journal February 2014
Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis journal February 2010
Very high pressure HPLC with 1 mm id columns journal April 2004
Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics journal December 2005
A fully automated synthesis of [ 18 F]-FEAU and [ 18 F]-FMAU using a novel dual reactor radiosynthesis module journal November 2009
A synthesis of 9-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)adenine and -hypoxanthine. An effect of C3'-endo to C2'-endo conformational shift on the reaction course of 2'-hydroxyl group with DAST journal January 1992
Automation for Optimised Production of Fluorine-18-Labelled Radiopharmaceuticals journal July 2010
Fluorine-18 radiopharmaceuticals beyond [18F]FDG for use in oncology and neurosciences journal October 2010
Synthesis of [18F]-labeled adenosine analogues as potential PET imaging agents
  • Alauddin, Mian M.; Fissekis, John D.; Conti, Peter S.
  • Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 46, Issue 9, p. 805-814 https://doi.org/10.1002/jlcr.712
journal January 2003
Introduction journal December 2011
A retrospective on the automation of laboratory synthetic chemistry journal October 1992
Synthesis of 2′-deoxy-2′-[18F]fluoro-β-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU and [18F]FIAU, as potential PET agents for imaging cellular proliferation: synthesis of [18F]labelled FAU, FMAU, FBAU, FIAU journal April 2003
Accurate dispensing of volatile reagents on demand for chemical reactions in EWOD chips journal January 2012
The improved syntheses of 5-substituted 2′-[18F]fluoro-2′-deoxy-arabinofuranosyluracil derivatives ([18F]FAU, [18F]FEAU, [18F]FFAU, [18F]FCAU, [18F]FBAU and [18F]FIAU) using a multistep one-pot strategy journal July 2011
Improved synthesis of 2′-deoxy-2′-[18F]-fluoro-1-β-d-arabinofuranosyl-5-iodouracil ([18F]-FIAU) journal May 2010
Microfluidics for Positron Emission Tomography Probe Development journal July 2010
Positron Emission Tomography (PET) and Microfluidic Devices: A Breakthrough on the Microscale? journal March 2007
Automated synthesis of 2′-deoxy-2′-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil ([18F]-FMAU) using a one reactor radiosynthesis module journal February 2011
Microchip HPLC of Peptides and Proteins journal May 2005
Dried Blood Spot Analysis by Digital Microfluidics Coupled to Nanoelectrospray Ionization Mass Spectrometry journal March 2012
Micro-chemical synthesis of molecular probes on an electronic microfluidic device journal December 2011
A World-to-Chip Interface for Digital Microfluidics journal February 2009
Synthesis of Diverse Tracers on ewod Microdevice for Positron Emission Tomography (Pet) conference May 2012

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