Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy

Lesman-Segev, Orit H.; La Joie, Renaud; Stephens, Melanie L.; Sonni, Ida; Tsai, Richard; Bourakova, Viktoriya; Visani, Adrienne V.; Edwards, Lauren; O'Neil, James P.; Baker, Suzanne L; Gardner, Raquel C.; Janabi, Mustafa; Chaudhary, Kiran; Perry, David C.; Kramer, Joel H.; Miller, Bruce L.; Jagust, William J.; Rabinovici, Gil D.

doi:10.1016/j.nicl.2019.102025

Title: Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy

Journal Article · Thu Oct 17 00:00:00 EDT 2019 · NeuroImage: Clinical

DOI:https://doi.org/10.1016/j.nicl.2019.102025· OSTI ID:1599790

Lesman-Segev, Orit H. ^[1]; La Joie, Renaud ^[1]; Stephens, Melanie L. ^[1];

^[2]; Tsai, Richard ^[1]; Bourakova, Viktoriya ^[1]; Visani, Adrienne V. ^[1]; Edwards, Lauren ^[1]; O'Neil, James P. ^[2]; Baker, Suzanne L ^[2]; Gardner, Raquel C. ^[3]; Janabi, Mustafa ^[2]; Chaudhary, Kiran ^[1]; Perry, David C. ^[1]; Kramer, Joel H. ^[1]; Miller, Bruce L. ^[1]; Jagust, William J. ^[4]; Rabinovici, Gil D. ^[5]

Univ. of California, San Francisco, CA (United States)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Univ. of California, San Francisco, CA (United States); San Francisco Veterans Affair Medical Center, CA (United States)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States)
Univ. of California, San Francisco, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States)

OBJECTIVE: To characterize individual and group-level neuroimaging findings in patients at risk for Chronic Traumatic Encephalopathy (CTE). METHODS: Eleven male patients meeting criteria for Traumatic Encephalopathy Syndrome (TES, median age: 64) underwent neurologic evaluation, 3-Tesla MRI, and PET with [¹⁸F]-Flortaucipir (FTP, tau-PET) and [¹¹C]-Pittsburgh compound B (PIB, amyloid-PET). Six patients underwent [¹⁸F]-Fluorodeoxyglucose-PET (FDG, glucose metabolism). We assessed imaging findings at the individual patient level, and in group-level comparisons with modality-specific groups of cognitively normal older adults (CN). Tau-PET findings in patients with TES were also compared to a matched group of patients with mild cognitive impairment or dementia due to Alzheimer's disease (AD). RESULTS: All patients with TES sustained repetitive head injury participating in impact sports, ten in American football. Three patients met criteria for dementia and eight had mild cognitive impairment. Two patients were amyloid-PET positive and harbored the most severe MRI atrophy, FDG hypometabolism, and FTP-tau PET binding. Among the nine amyloid-negative patients, tau-PET showed either mildly elevated frontotemporal binding, a "dot-like" pattern, or no elevated binding. Medial temporal FTP was mildly elevated in a subset of amyloid-negative patients, but values were considerably lower than in AD. Voxelwise analyses revealed a convergence of imaging abnormalities (higher FTP binding, lower FDG, lower gray matter volumes) in frontotemporal areas in TES compared to controls. CONCLUSIONS: Mildly elevated tau-PET binding was observed in a subset of amyloid-negative patients at risk for CTE, in a distribution consistent with CTE pathology stages III-IV. FTP-PET may be useful as a biomarker of tau pathology in CTE but is unlikely to be sensitive to early disease stages.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC); National Institute on Aging; Alzheimer's Association

Grant/Contract Number:: AC02-05CH11231; R01-AG045611; R01-AG034570; P50-AG023501; AARF-16-443577

OSTI ID:: 1599790

Journal Information:: NeuroImage: Clinical, Vol. 24, Issue C; ISSN 2213-1582

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 29 works

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References (66)

Corrigendum to ‘Normative morphometric data for cerebral cortical areas over the lifetime of the adult human brain’ [NeuroImage 156 (2017) 315–339] Potvin, Olivier; Dieumegarde, Louis; Duchesne, Simon NeuroImage, Vol. 183 https://doi.org/10.1016/j.neuroimage.2018.09.019	journal	December 2018
Cavum Septi Pellucidi in Symptomatic Former Professional Football Players Koerte, Inga K.; Hufschmidt, Jakob; Muehlmann, Marc Journal of Neurotrauma, Vol. 33, Issue 4 https://doi.org/10.1089/neu.2015.3880	journal	February 2016
The clinical spectrum of sport-related traumatic brain injury Jordan, Barry D. Nature Reviews Neurology, Vol. 9, Issue 4 https://doi.org/10.1038/nrneurol.2013.33	journal	March 2013
Current Understanding of Chronic Traumatic Encephalopathy Baugh, Christine M.; Robbins, Clifford A.; Stern, Robert A. Current Treatment Options in Neurology, Vol. 16, Issue 9 https://doi.org/10.1007/s11940-014-0306-5	journal	July 2014
In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging Barrio, Jorge R.; Small, Gary W.; Wong, Koon-Pong Proceedings of the National Academy of Sciences, Vol. 112, Issue 16 https://doi.org/10.1073/pnas.1409952112	journal	April 2015
BrainNet Viewer: A Network Visualization Tool for Human Brain Connectomics Xia, Mingrui; Wang, Jinhui; He, Yong PLoS ONE, Vol. 8, Issue 7 https://doi.org/10.1371/journal.pone.0068910	journal	July 2013
Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET Ossenkoppele, Rik; Tolboom, Nelleke; Foster-Dingley, Jessica C. European Journal of Nuclear Medicine and Molecular Imaging, Vol. 39, Issue 6 https://doi.org/10.1007/s00259-012-2102-3	journal	March 2012
Clinical subtypes of chronic traumatic encephalopathy: literature review and proposed research diagnostic criteria for traumatic encephalopathy syndrome Montenigro, Philip H.; Baugh, Christine M.; Daneshvar, Daniel H. Alzheimer's Research & Therapy, Vol. 6, Issue 5-8 https://doi.org/10.1186/s13195-014-0068-z	journal	September 2014
Executive Dysfunction Rabinovici, Gil D.; Stephens, Melanie L.; Possin, Katherine L. CONTINUUM: Lifelong Learning in Neurology, Vol. 21 https://doi.org/10.1212/01.con.0000466658.05156.54	journal	June 2015
Beta-amyloid deposition in chronic traumatic encephalopathy Stein, Thor D.; Montenigro, Philip H.; Alvarez, Victor E. Acta Neuropathologica, Vol. 130, Issue 1 https://doi.org/10.1007/s00401-015-1435-y	journal	May 2015
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease Ikonomovic, Milos D.; Klunk, William E.; Abrahamson, Eric E. Brain, Vol. 131, Issue 6 https://doi.org/10.1093/brain/awn016	journal	March 2008
Traumatic Brain Injury: A Review and High-Field MRI Findings in 100 Unarmed Combatants Using a Literature-Based Checklist Approach Orrison, William W.; Hanson, Eric H.; Alamo, Tony Journal of Neurotrauma, Vol. 26, Issue 5 https://doi.org/10.1089/neu.2008.0636	journal	May 2009
The spectrum of disease in chronic traumatic encephalopathy McKee, Ann C.; Stein, Thor D.; Nowinski, Christopher J. Brain, Vol. 136, Issue 1 https://doi.org/10.1093/brain/aws307	journal	December 2012
Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson’s case Marquié, Marta; Verwer, Eline E.; Meltzer, Avery C. Acta Neuropathologica Communications, Vol. 5, Issue 1 https://doi.org/10.1186/s40478-017-0482-0	journal	October 2017
Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury Mitsis, E. M.; Riggio, S.; Kostakoglu, L. Translational Psychiatry, Vol. 4, Issue 9 https://doi.org/10.1038/tp.2014.91	journal	September 2014
Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study Mez, Jesse; Solomon, Todd M.; Daneshvar, Daniel H. Alzheimer's Research & Therapy, Vol. 7, Issue 1 https://doi.org/10.1186/s13195-015-0148-8	journal	October 2015
Region-Specific Hierarchy between Atrophy, Hypometabolism, and -Amyloid (A ) Load in Alzheimer's Disease Dementia La Joie, R.; Perrotin, A.; Barre, L. Journal of Neuroscience, Vol. 32, Issue 46 https://doi.org/10.1523/jneurosci.2170-12.2012	journal	November 2012
Development and validation of a geriatric depression screening scale: A preliminary report Yesavage, Jerome A.; Brink, T. L.; Rose, Terence L. Journal of Psychiatric Research, Vol. 17, Issue 1 https://doi.org/10.1016/0022-3956(82)90033-4	journal	January 1982
Knowledge, Attitude, and Concussion-Reporting Behaviors Among High School Athletes: A Preliminary Study W., Marshall, Stephen; M., Guskiewicz, Kevin; K., Register-Mihalik, Johna The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/ef9s-h051	text	January 2013
Cavum Septum Pellucidum in Retired American Pro-Football Players Gardner, Raquel C.; Hess, Christopher P.; Brus-Ramer, Marcel Journal of Neurotrauma, Vol. 33, Issue 1 https://doi.org/10.1089/neu.2014.3805	journal	January 2016
Uptake of AV-1451 in meningiomas Bruinsma, Tyler J.; Johnson, Derek R.; Fang, Ping Annals of Nuclear Medicine, Vol. 31, Issue 10 https://doi.org/10.1007/s12149-017-1205-0	journal	September 2017
18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal Lee, Christopher M.; Jacobs, Heidi I. L.; Marquié, Marta Journal of Alzheimer's Disease, Vol. 62, Issue 4 https://doi.org/10.3233/jad-170840	journal	March 2018
Reducing between scanner differences in multi-center PET studies Joshi, Aniket; Koeppe, Robert A.; Fessler, Jeffrey A. NeuroImage, Vol. 46, Issue 1 https://doi.org/10.1016/j.neuroimage.2009.01.057	journal	May 2009
Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury Ikonomovic, Milos D.; Uryu, Kunihiro; Abrahamson, Eric E. Experimental Neurology, Vol. 190, Issue 1 https://doi.org/10.1016/j.expneurol.2004.06.011	journal	November 2004
Test Review: Delis-Kaplan Executive Function System Homack, Susan; Lee, Donghyung; Riccio, Cynthia A. Journal of Clinical and Experimental Neuropsychology, Vol. 27, Issue 5 https://doi.org/10.1080/13803390490918444	journal	July 2005
Distinctive Neuropsychological Patterns in Frontotemporal Dementia, Semantic Dementia, And Alzheimer Disease Kramer, Joel H.; Jurik, Jennifer; Sha, Sharon J. Cognitive and Behavioral Neurology, Vol. 16, Issue 4 https://doi.org/10.1097/00146965-200312000-00002	journal	January 2003
Elevated 18 F-AV-1451 PET tracer uptake detected in incidental imaging findings Lockhart, Samuel N.; Ayakta, Nagehan; Winer, Joseph R. Neurology, Vol. 88, Issue 11 https://doi.org/10.1212/wnl.0000000000003724	journal	February 2017
PET Scanning of Brain Tau in Retired National Football League Players: Preliminary Findings Small, Gary W.; Kepe, Vladimir; Siddarth, Prabha The American Journal of Geriatric Psychiatry, Vol. 21, Issue 2 https://doi.org/10.1016/j.jagp.2012.11.019	journal	February 2013
Evaluating and treating neurobehavioral symptoms in professional American football players Gardner, Raquel C.; Possin, Katherine L.; Hess, Christopher P. Neurology: Clinical Practice, Vol. 5, Issue 4 https://doi.org/10.1212/cpj.0000000000000157	journal	August 2015
Traumatic encephalopathy: Review and provisional research diagnostic criteria Victoroff, Jeff NeuroRehabilitation, Vol. 32, Issue 2 https://doi.org/10.3233/nre-130839	journal	April 2013
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease McKhann, Guy M.; Knopman, David S.; Chertkow, Howard Alzheimer's & Dementia, Vol. 7, Issue 3 https://doi.org/10.1016/j.jalz.2011.03.005	journal	May 2011
An autoradiographic evaluation of AV-1451 Tau PET in dementia Lowe, Val J.; Curran, Geoffry; Fang, Ping Acta Neuropathologica Communications, Vol. 4, Issue 1 https://doi.org/10.1186/s40478-016-0315-6	journal	June 2016
Studies of interference in serial verbal reactions. Stroop, J. R. Journal of Experimental Psychology, Vol. 18, Issue 6 https://doi.org/10.1037/h0054651	journal	January 1935
Neuropsychological, Metabolic, and GABA_AReceptor Studies in Subjects with Repetitive Traumatic Brain Injury Bang, Seong Ae; Song, Yoo Sung; Moon, Byung Seok Journal of Neurotrauma, Vol. 33, Issue 11 https://doi.org/10.1089/neu.2015.4051	journal	June 2016
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest Desikan, Rahul S.; Ségonne, Florent; Fischl, Bruce NeuroImage, Vol. 31, Issue 3 https://doi.org/10.1016/j.neuroimage.2006.01.021	journal	July 2006
F-18 FDG PET imaging of chronic traumatic brain injury in boxers Provenzano, Frank Anthony; Jordan, Barry; Tikofsky, Ronald S. Nuclear Medicine Communications, Vol. 31, Issue 11 https://doi.org/10.1097/mnm.0b013e32833e37c4	journal	November 2010
Flortaucipir tau PET imaging in semantic variant primary progressive aphasia Makaretz, Sara J.; Quimby, Megan; Collins, Jessica Journal of Neurology, Neurosurgery & Psychiatry, Vol. 89, Issue 10 https://doi.org/10.1136/jnnp-2017-316409	journal	October 2017
Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms Peskind, Elaine R.; Petrie, Eric C.; Cross, Donna J. NeuroImage, Vol. 54 https://doi.org/10.1016/j.neuroimage.2010.04.008	journal	January 2011
Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults Buckley, Rachel F.; Mormino, Elizabeth C.; Rabin, Jennifer S. JAMA Neurology, Vol. 76, Issue 5 https://doi.org/10.1001/jamaneurol.2018.4693	journal	May 2019
Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration Alosco, Michael L.; Tripodis, Yorghos; Fritts, Nathan G. Alzheimer's & Dementia, Vol. 14, Issue 9 https://doi.org/10.1016/j.jalz.2018.05.004	journal	July 2018
18 F-AV-1451 binds to motor-related subcortical gray and white matter in corticobasal syndrome Cho, Hanna; Baek, Min Seok; Choi, Jae Yong Neurology, Vol. 89, Issue 11 https://doi.org/10.1212/WNL.0000000000004364	journal	August 2017
Cerebral [18 F]T807/AV1451 retention pattern in clinically probable CTE resembles pathognomonic distribution of CTE tauopathy Dickstein, D. L.; Pullman, M. Y.; Fernandez, C. Translational Psychiatry, Vol. 6, Issue 9 https://doi.org/10.1038/tp.2016.175	journal	September 2016
A probabilistic MR atlas of the human cerebellum Diedrichsen, Jörn; Balsters, Joshua H.; Flavell, Jonathan NeuroImage, Vol. 46, Issue 1 https://doi.org/10.1016/j.neuroimage.2009.01.045	journal	May 2009
Multisite study of the relationships between antemortem [ ¹¹ C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology La Joie, Renaud; Ayakta, Nagehan; Seeley, William W. Alzheimer's & Dementia, Vol. 15, Issue 2 https://doi.org/10.1016/j.jalz.2018.09.001	journal	October 2018
Associations between [ 18 F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample La Joie, Renaud; Bejanin, Alexandre; Fagan, Anne M. Neurology, Vol. 90, Issue 4 https://doi.org/10.1212/WNL.0000000000004860	journal	December 2017
Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease Lehmann, Manja; Ghosh, Pia M.; Madison, Cindee Brain, Vol. 136, Issue 3 https://doi.org/10.1093/brain/aws327	journal	January 2013
Imaging chronic traumatic brain injury as a risk factor for neurodegeneration Little, Deborah M.; Geary, Elizabeth K.; Moynihan, Michael Alzheimer's & Dementia, Vol. 10, Issue 3S https://doi.org/10.1016/j.jalz.2014.04.002	journal	June 2014
Widespread brain tau and its association with ageing, Braak stage and Alzheimer’s dementia Lowe, Val J.; Wiste, Heather J.; Senjem, Matthew L. Brain, Vol. 141, Issue 1 https://doi.org/10.1093/brain/awx320	journal	December 2017
Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease Maass, Anne; Landau, Susan; Baker, Suzanne L. NeuroImage, Vol. 157 https://doi.org/10.1016/j.neuroimage.2017.05.058	journal	August 2017
Accurate automatic estimation of total intracranial volume: A nuisance variable with less nuisance Malone, Ian B.; Leung, Kelvin K.; Clegg, Shona NeuroImage, Vol. 104 https://doi.org/10.1016/j.neuroimage.2014.09.034	journal	January 2015
Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue: Validation of PET Tracer Marquié, Marta; Normandin, Marc D.; Vanderburg, Charles R. Annals of Neurology, Vol. 78, Issue 5 https://doi.org/10.1002/ana.24517	journal	September 2015
Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football Mez, Jesse; Daneshvar, Daniel H.; Kiernan, Patrick T. JAMA, Vol. 318, Issue 4 https://doi.org/10.1001/jama.2017.8334	journal	July 2017
The Clinical Dementia Rating (CDR): Current version and scoring rules Morris, J. C. Neurology, Vol. 43, Issue 11 https://doi.org/10.1212/WNL.43.11.2412-a	journal	November 1993
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease Ossenkoppele, Rik; Schonhaut, Daniel R.; Schöll, Michael Brain, Vol. 139, Issue 5 https://doi.org/10.1093/brain/aww027	journal	March 2016
Normative morphometric data for cerebral cortical areas over the lifetime of the adult human brain Potvin, Olivier; Dieumegarde, Louis; Duchesne, Simon NeuroImage, Vol. 156 https://doi.org/10.1016/j.neuroimage.2017.05.019	journal	August 2017
Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD Rabinovici, G. D.; Rosen, H. J.; Alkalay, A. Neurology, Vol. 77, Issue 23 https://doi.org/10.1212/WNL.0b013e31823b9c5e	journal	November 2011
A Clinical Approach to the Diagnosis of Traumatic Encephalopathy Syndrome Reams, Nicole; Eckner, James T.; Almeida, Andrea A. JAMA Neurology, Vol. 73, Issue 6 https://doi.org/10.1001/jamaneurol.2015.5015	journal	June 2016
Knowledge, Attitude, and Concussion-Reporting Behaviors Among High School Athletes: A Preliminary Study Register-Mihalik, Johna K.; Guskiewicz, Kevin M.; McLeod, Tamara C. Valovich Journal of Athletic Training, Vol. 48, Issue 5 https://doi.org/10.4085/1062-6050-48.3.20	journal	October 2013
βA4 amyloid protein deposition in brain after head trauma Roberts, G. W.; Gentleman, S. M.; Lynch, A. The Lancet, Vol. 338, Issue 8780 https://doi.org/10.1016/0140-6736(91)92724-G	journal	December 1991
Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease. Roberts, G. W.; Gentleman, S. M.; Lynch, A. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 57, Issue 4 https://doi.org/10.1136/jnnp.57.4.419	journal	April 1994
Characterization of tau positron emission tomography tracer [ 18 F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias Sander, Kerstin; Lashley, Tammaryn; Gami, Priya Alzheimer's & Dementia, Vol. 12, Issue 11 https://doi.org/10.1016/j.jalz.2016.01.003	journal	November 2016
18 F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study : Flortaucipir Tau PET in PSP Schonhaut, Daniel R.; McMillan, Corey T.; Spina, Salvatore Annals of Neurology, Vol. 82, Issue 4 https://doi.org/10.1002/ana.25060	journal	October 2017
Regional correlations between [ 11 C]PIB PET and post-mortem burden of amyloid-beta pathology in a diverse neuropathological cohort Seo, Sang Won; Ayakta, Nagehan; Grinberg, Lea T. NeuroImage: Clinical, Vol. 13 https://doi.org/10.1016/j.nicl.2016.11.008	journal	January 2017
The 2,6-Disubstituted Naphthalene Derivative FDDNP Labeling Reliably Predicts Congo Red Birefringence of Protein Deposits in Brain Sections of Selected Human Neurodegenerative Diseases Smid, Lojze M.; Vovko, Tomaz D.; Popovic, Mara Brain Pathology, Vol. 16, Issue 2 https://doi.org/10.1111/j.1750-3639.2006.00006.x	journal	April 2006
In vivo retention of 18 F-AV-1451 in corticobasal syndrome Smith, Ruben; Schöll, Michael; Widner, Håkan Neurology, Vol. 89, Issue 8 https://doi.org/10.1212/WNL.0000000000004264	journal	July 2017
Tau-PET imaging with [18F]AV-1451 in primary progressive apraxia of speech Utianski, Rene L.; Whitwell, Jennifer L.; Schwarz, Christopher G. Cortex, Vol. 99 https://doi.org/10.1016/j.cortex.2017.12.021	journal	February 2018

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60 APPLIED LIFE SCIENCES
chronic traumatic encephalopathy (CTE)
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positron emission tomography (PET)
tau
amyloid
magnetic resonance imaging (MRI)

Title: Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy

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