Bayesian algorithms for recovering structure from single-particle diffraction snapshots of unknown orientation: a comparison
Journal Article
·
· Acta Crystallographica. Section A, Foundations of Crystallography
- Univ. of Wisconsin, Milwaukee, WI (United States)
The advent of X-ray free-electron lasers promises the possibility to determine the structure of individual particles such as microcrystallites, viruses and biomolecules from single-shot diffraction snapshots obtained before the particle is destroyed by the intense femtosecond pulse. This program requires the ability to determine the orientation of the particle giving rise to each snapshot at signal levels as low as ~10-2 photons per pixel. Two apparently different approaches have recently demonstrated this capability. Here we show they represent different implementations of the same fundamental approach, and identify the primary factors limiting their performance.
- Research Organization:
- Univ. of Wisconsin, Milwaukee, WI (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- Grant/Contract Number:
- SC0002164
- OSTI ID:
- 1598203
- Journal Information:
- Acta Crystallographica. Section A, Foundations of Crystallography, Vol. 67, Issue 5; ISSN 0108-7673
- Publisher:
- International Union of CrystallographyCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Cited by: 20 works
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