Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor

Min, Xiaoshan; Yie, Junming; Wang, Jinghong; Chung, Ben C.; Huang, Ching-Shin; Xu, Haoda; Yang, Jie; Deng, Liying; Lin, Joanne; Chen, Qing; Abbott, Christina M.; Gundel, Caroline; Thibault, Stephen A.; Meng, Tina; Bates, Darren L.; Lloyd, David J.; Véniant, Murielle M.; Wang, Zhulun

doi:10.1080/19420862.2019.1710047

Title: Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor

Journal Article · Wed Jan 22 00:00:00 EST 2020 · MABS-Austin

DOI:https://doi.org/10.1080/19420862.2019.1710047· OSTI ID:1593450

Min, Xiaoshan; Yie, Junming; Wang, Jinghong; Chung, Ben C.; Huang, Ching-Shin; Xu, Haoda; Yang, Jie; Deng, Liying; Lin, Joanne; Chen, Qing; Abbott, Christina M.; Gundel, Caroline; Thibault, Stephen A.; Meng, Tina; Bates, Darren L.; Lloyd, David J.; Véniant, Murielle M.; Wang, Zhulun ^[1]

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: INDUSTRY

OSTI ID:: 1593450

Journal Information:: MABS-Austin, Vol. 12, Issue (1) ; 2020

Country of Publication:: United States

Language:: ENGLISH

References (43)

Biology of Incretins: GLP-1 and GIP Baggio, Laurie L.; Drucker, Daniel J. Gastroenterology, Vol. 132, Issue 6 https://doi.org/10.1053/j.gastro.2007.03.054	journal	May 2007
Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action Campbell, Jonathan E.; Drucker, Daniel J. Cell Metabolism, Vol. 17, Issue 6 https://doi.org/10.1016/j.cmet.2013.04.008	journal	June 2013
Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications Irwin, N.; Flatt, P. R. Diabetologia, Vol. 52, Issue 9 https://doi.org/10.1007/s00125-009-1422-8	journal	June 2009
Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Kieffer, T. J.; McIntosh, C. H.; Pederson, R. A. Endocrinology, Vol. 136, Issue 8 https://doi.org/10.1210/endo.136.8.7628397	journal	August 1995
Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. Usdin, T. B.; Mezey, E.; Button, D. C. Endocrinology, Vol. 133, Issue 6 https://doi.org/10.1210/endo.133.6.8243312	journal	December 1993
Direct metabolic effects of gastric inhibitory polypeptide (GIP): dissociation at physiological levels of effects on insulin-stimulated fatty acid and glucose incorporation in rat adipose tissue Beck, Bernard; Max, J. -P. Diabetologia, Vol. 29, Issue 1 https://doi.org/10.1007/BF02427284	journal	January 1986
Activation of Lipoprotein Lipase by Glucose-dependent Insulinotropic Polypeptide in Adipocytes Kim, Su-Jin; Nian, Cuilan; McIntosh, Christopher H. S. Journal of Biological Chemistry, Vol. 282, Issue 12 https://doi.org/10.1074/jbc.M609088200	journal	January 2007
Glucose-Dependent Insulinotropic Polypeptide Modulates Adipocyte Lipolysis and Reesterification* Getty-Kaushik, Lisa; Song, Diane H.; Boylan, Michael O. Obesity, Vol. 14, Issue 7 https://doi.org/10.1038/oby.2006.129	journal	July 2006
Exogenous Glucose-Dependent Insulinotropic Polypeptide Worsens Post prandial Hyperglycemia in T ype 2 Diabetes Chia, C. W.; Carlson, O. D.; Kim, W. Diabetes, Vol. 58, Issue 6 https://doi.org/10.2337/db08-0958	journal	March 2009
Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia Meier, J. J.; Gallwitz, B.; Siepmann, N. Diabetologia, Vol. 46, Issue 6 https://doi.org/10.1007/s00125-003-1103-y	journal	June 2003
Glucose-Dependent Insulinotropic Polypeptide: A Bifunctional Glucose-Dependent Regulator of Glucagon and Insulin Secretion in Humans Christensen, M.; Vedtofte, L.; Holst, J. J. Diabetes, Vol. 60, Issue 12 https://doi.org/10.2337/db11-0979	journal	October 2011
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index Speliotes, Elizabeth K.; Willer, Cristen J.; Berndt, Sonja I. Nature Genetics, Vol. 42, Issue 11 https://doi.org/10.1038/ng.686	journal	October 2010
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations Okada, Yukinori; Kubo, Michiaki; Ohmiya, Hiroko Nature Genetics, Vol. 44, Issue 3 https://doi.org/10.1038/ng.1086	journal	February 2012
Meta-analysis identifies common variants associated with body mass index in east Asians Wen, Wanqing; Cho, Yoon-Shin; Zheng, Wei Nature Genetics, Vol. 44, Issue 3 https://doi.org/10.1038/ng.1087	journal	February 2012
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture Berndt, Sonja I.; Gustafsson, Stefan; Mägi, Reedik Nature Genetics, Vol. 45, Issue 5 https://doi.org/10.1038/ng.2606	journal	April 2013
Inhibition of gastric inhibitory polypeptide signaling prevents obesity Miyawaki, Kazumasa; Yamada, Yuichiro; Ban, Nobuhiro Nature Medicine, Vol. 8, Issue 7 https://doi.org/10.1038/nm727	journal	June 2002
Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice Faivre, Emilie; Hamilton, Alison; Hölscher, Christian European Journal of Pharmacology, Vol. 674, Issue 2-3 https://doi.org/10.1016/j.ejphar.2011.11.007	journal	January 2012
Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors Hoare, S. Drug Discovery Today, Vol. 10, Issue 6 https://doi.org/10.1016/S1359-6446(05)03370-2	journal	March 2005
Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors Culhane, Kelly J.; Liu, Yuting; Cai, Yingying Frontiers in Pharmacology, Vol. 6 https://doi.org/10.3389/fphar.2015.00264	journal	November 2015
Extra-helical binding site of a glucagon receptor antagonist Jazayeri, Ali; Doré, Andrew S.; Lamb, Daniel Nature, Vol. 533, Issue 7602 https://doi.org/10.1038/nature17414	journal	April 2016
Structure of the human glucagon class B G-protein-coupled receptor Siu, Fai Yiu; He, Min; de Graaf, Chris Nature, Vol. 499, Issue 7459 https://doi.org/10.1038/nature12393	journal	July 2013
Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators Song, Gaojie; Yang, Dehua; Wang, Yuxia Nature, Vol. 546, Issue 7657 https://doi.org/10.1038/nature22378	journal	May 2017
Phase-plate cryo-EM structure of a class B GPCR–G-protein complex Liang, Yi-Lynn; Khoshouei, Maryam; Radjainia, Mazdak Nature, Vol. 546, Issue 7656 https://doi.org/10.1038/nature22327	journal	April 2017
Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein Zhang, Yan; Sun, Bingfa; Feng, Dan Nature, Vol. 546, Issue 7657 https://doi.org/10.1038/nature22394	journal	May 2017
Structure of the full-length glucagon class B G-protein-coupled receptor Zhang, Haonan; Qiao, Anna; Yang, Dehua Nature, Vol. 546, Issue 7657 https://doi.org/10.1038/nature22363	journal	May 2017
Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor Ravn, Peter; Madhurantakam, Chaithanya; Kunze, Susan Journal of Biological Chemistry, Vol. 288, Issue 27 https://doi.org/10.1074/jbc.M112.426288	journal	May 2013
Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor Mukund, Susmith; Shang, Yonglei; Clarke, Holly J. Journal of Biological Chemistry, Vol. 288, Issue 50 https://doi.org/10.1074/jbc.M113.496984	journal	November 2013
Structural insight into antibody-mediated antagonism of the Glucagon-like peptide-1 Receptor Hennen, Stephanie; Kodra, János T.; Soroka, Vladyslav Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep26236	journal	May 2016
Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition Kaneko, Kentaro; Fu, Yukiko; Lin, Hsiao-Yun Journal of Clinical Investigation, Vol. 129, Issue 9 https://doi.org/10.1172/JCI126107	journal	August 2019
Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models Killion, Elizabeth A.; Wang, Jinghong; Yie, Junming Science Translational Medicine, Vol. 10, Issue 472 https://doi.org/10.1126/scitranslmed.aat3392	journal	December 2018
Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor Parthier, C.; Kleinschmidt, M.; Neumann, P. Proceedings of the National Academy of Sciences, Vol. 104, Issue 35 https://doi.org/10.1073/pnas.0706404104	journal	August 2007
Passing the baton in class B GPCRs: peptide hormone activation via helix induction? Parthier, Christoph; Reedtz-Runge, Steffen; Rudolph, Rainer Trends in Biochemical Sciences, Vol. 34, Issue 6 https://doi.org/10.1016/j.tibs.2009.02.004	journal	June 2009
The effects of glucose-dependent insulinotropic polypeptide infused at physiological concentrations in normal subjects and Type 2 (non-insulin-dependent) diabetic patients on glucose tolerance and B-cell secretion Jones, I. R.; Owens, D. R.; Moody, A. J. Diabetologia, Vol. 30, Issue 9 https://doi.org/10.1007/BF00296993	journal	September 1987
Molecular Approximation between a Residue in the Amino-terminal Region of Calcitonin and the Third Extracellular Loop of the Class B G Protein-coupled Calcitonin Receptor Dong, Maoqing; Pinon, Delia I.; Cox, Richard F. Journal of Biological Chemistry, Vol. 279, Issue 30 https://doi.org/10.1074/jbc.M404113200	journal	May 2004
Molecular basis for negative regulation of the glucagon receptor Koth, C. M.; Murray, J. M.; Mukund, S. Proceedings of the National Academy of Sciences, Vol. 109, Issue 36 https://doi.org/10.1073/pnas.1206734109	journal	August 2012
Structure of the glucagon receptor in complex with a glucagon analogue Zhang, Haonan; Qiao, Anna; Yang, Linlin Nature, Vol. 553, Issue 7686 https://doi.org/10.1038/nature25153	journal	January 2018
Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans Finan, B.; Ma, T.; Ottaway, N. Science Translational Medicine, Vol. 5, Issue 209 https://doi.org/10.1126/scitranslmed.3007218	journal	October 2013
Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial Frias, Juan Pablo; Nauck, Michael A.; Van, Joanna The Lancet, Vol. 392, Issue 10160 https://doi.org/10.1016/S0140-6736(18)32260-8	journal	November 2018
Phaser crystallographic software McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Journal of Applied Crystallography, Vol. 40, Issue 4 https://doi.org/10.1107/S0021889807021206	journal	July 2007
Coot model-building tools for molecular graphics Emsley, Paul; Cowtan, Kevin Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132 https://doi.org/10.1107/S0907444904019158	journal	November 2004
Refinement of Macromolecular Structures by the Maximum-Likelihood Method Murshudov, G. N.; Vagin, A. A.; Dodson, E. J. Acta Crystallographica Section D Biological Crystallography, Vol. 53, Issue 3 https://doi.org/10.1107/S0907444996012255	journal	May 1997
The CCP4 suite programs for protein crystallography Acta Crystallographica Section D Biological Crystallography, Vol. 50, Issue 5, p. 760-763 https://doi.org/10.1107/S0907444994003112	journal	September 1994
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010

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