Nanoproteomics Comes of Age

Zhu, Ying; Piehowski, Paul D.; Kelly, Ryan T.; Qian, Weijun

doi:10.1080/14789450.2018.1537787

Nanoproteomics Comes of Age

Journal Article · Thu Nov 01 04:00:00 EDT 2018 · Expert Review of Proteomics

DOI:https://doi.org/10.1080/14789450.2018.1537787· OSTI ID:1582608

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BATTELLE (PACIFIC NW LAB)

Substantial technological advances have been made towards making enabling a nanoproteomics capability, i.e., quantitative proteome profiling of small cell populations (<5000 cells). These advances include new technologies or approaches from all areas of the overall proteomics workflow ranging from sample isolation, sample processing, high resolution separations, MS detection, to informatics. Herein we present a brief review of the recent technological advances, the current state of nanoproteomics, and future perspectives on both the technological direction and potential enabling applications.

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RL01830

OSTI ID:: 1582608

Report Number(s):: PNNL-SA-136396

Journal Information:: Expert Review of Proteomics, Journal Name: Expert Review of Proteomics Journal Issue: 11 Vol. 15

Country of Publication:: United States

Language:: English

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References (46)

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