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Title: Accumulated mutations by 6 months of infection collectively render transmitted/founder HIV-1 significantly less fit

Journal Article · · Journal of Infection
 [1];  [2];  [1];  [3];  [3];  [4];  [4];  [4];  [5];  [5]; ORCiD logo [6]; ORCiD logo [6];  [1]
  1. Jilin Univ., Jilin Province (China); Duke Univ. Medical Center, Durham, NC (United States)
  2. Jilin Univ., Jilin Province (China); Duke Univ. Medical Center, Durham, NC (United States); National Inst. for Food and Drug Control, Beijing (China)
  3. Duke Univ. Medical Center, Durham, NC (United States)
  4. Univ. of Alabama at Birmingham, Birmingham, AL (United States)
  5. Jilin Univ., Jilin Province (China)
  6. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
+ Show Author Affiliations

Viral fitness plays an important role in HIV-1 evolution, transmission and pathogenesis. However, how mutations accumulated during early infection affect viral fitness has not been well studied. We generated paired infectious molecular clones (IMCs) for transmitted/founder (T/F) and 6-month (6-mo) viruses post infection from 10 infected individuals to investigate the impact of accumulated mutations on viral fitness by comparing 6-mo viruses to their cognate T/F viruses. We found that all ten 6-mo viruses were less fit than their cognate T/F viruses. Moreover, the fitness losses of the 6-mo viruses correlated with the decrease in viral loads from the peak of viremia. Furthermore, these results show that the mutations accumulated during half a year post infection collectively reduce viral fitness and thereby contribute to lowering viral loads.

Research Organization:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
National Institutes of Health (NIH); USDOE
Grant/Contract Number:
89233218CNA000001; R01AI087520; R01AI028433; R01OD011095; AI067854; AI100645; 31670162; 2018ZX10731101-001-010; 2017TD-05; BX20180124; 2018M641786
OSTI ID:
1579704
Report Number(s):
LA-UR-19-30331
Journal Information:
Journal of Infection, Vol. 80, Issue 2; ISSN 0163-4453
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 2 works
Citation information provided by
Web of Science

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60 APPLIED LIFE SCIENCES
HIV-1
Mutation
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Transmitted/founder virus
Infection