Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics

Blue, Elizabeth E.; Horimoto, Andréa R. V. R.; Mukherjee, Shubhabrata; Wijsman, Ellen M.; Thornton, Timothy A.

doi:10.1016/j.jalz.2019.07.016

Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics

Journal Article · Wed Oct 09 00:00:00 EDT 2019 · Alzheimer's & Dementia

DOI:https://doi.org/10.1016/j.jalz.2019.07.016· OSTI ID:1579575

Blue, Elizabeth E. ^[1]; Horimoto, Andréa R. V. R. ^[2]; Mukherjee, Shubhabrata ^[3]; Wijsman, Ellen M. ^[4]; Thornton, Timothy A. ^[5]

Division of Medical Genetics University of Washington Seattle WA USA
Department of Biostatistics University of Washington Seattle WA USA
Department of Medicine University of Washington Seattle WA USA
Division of Medical Genetics University of Washington Seattle WA USA, Department of Biostatistics University of Washington Seattle WA USA, Department of Genome Sciences University of Washington Seattle WA USA
Department of Biostatistics University of Washington Seattle WA USA, Department of Statistics University of Washington Seattle WA USA

Abstract Introduction

Although the relationship between APOE and Alzheimer's disease (AD) is well established in populations of European descent, the effects of APOE and ancestry on AD risk in diverse populations is not well understood.

Methods

Logistic mixed model regression and survival analyses were performed in a sample of 3067 Caribbean Hispanics and 3028 individuals of European descent to assess the effects of APOE genotype, local ancestry, and genome‐wide ancestry on AD risk and age at onset.

Results

Among the Caribbean Hispanics, individuals with African‐derived ancestry at APOE had 39% lower odds of AD than individuals with European‐derived APOE , after adjusting for APOE genotype, age, and genome‐wide ancestry. While APOE E2 and E4 effects on AD risk and age at onset were significant in the Caribbean Hispanics, they were substantially attenuated compared with those in European ancestry individuals.

Discussion

These results suggest that additional genetic variation in the APOE region influences AD risk beyond APOE E2/E3/E4.

View Accepted Manuscript (Publisher)

Sponsoring Organization:: USDOE

OSTI ID:: 1579575

Journal Information:: Alzheimer's & Dementia, Journal Name: Alzheimer's & Dementia Journal Issue: 12 Vol. 15; ISSN 1552-5260

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: United States

Language:: English

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