The role of mutation accumulation in HIV progression
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journal
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July 2005 |
HIV Populations Are Large and Accumulate High Genetic Diversity in a Nonlinear Fashion
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journal
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September 2013 |
Marked infidelity of human immunodeficiency virus type 1 reverse transcriptase at RNA and DNA template ends.
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journal
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January 1994 |
Mutations in HIV-1 Reverse Transcriptase Affect the Errors Made in a Single Cycle of Viral Replication
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journal
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April 2014 |
Nature, Position, and Frequency of Mutations Made in a Single Cycle of HIV-1 Replication
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journal
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July 2010 |
Identifying Recombination Hot Spots in the HIV-1 Genome
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journal
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December 2013 |
Mutation Patterns and Structural Correlates in Human Immunodeficiency Virus Type 1 Protease following Different Protease Inhibitor Treatments
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journal
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April 2003 |
Role of Gag in HIV Resistance to Protease Inhibitors
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journal
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July 2010 |
Gag Mutations Strongly Contribute to HIV-1 Resistance to Protease Inhibitors in Highly Drug-Experienced Patients besides Compensating for Fitness Loss
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journal
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March 2009 |
Discovery and Selection of TMC114, a Next Generation HIV-1 Protease Inhibitor §
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journal
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March 2005 |
Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in Human Immunodeficiency Virus Type 1 Protease
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journal
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September 2007 |
Decomposing the Energetic Impact of Drug Resistant Mutations in HIV-1 Protease on Binding DRV
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journal
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March 2010 |
Substrate Shape Determines Specificity of Recognition for HIV-1 Protease
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journal
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March 2002 |
Molecular Basis for Drug Resistance in HIV-1 Protease
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journal
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November 2010 |
HIV protease inhibitors: a review of molecular selectivity and toxicity
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journal
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April 2015 |
Substrate Envelope-Designed Potent HIV-1 Protease Inhibitors to Avoid Drug Resistance
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journal
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September 2013 |
Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease
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journal
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December 2018 |
Fifteen years of HIV Protease Inhibitors: raising the barrier to resistance
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journal
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January 2010 |
A Major Role for a Set of Non-Active Site Mutations in the Development of HIV-1 Protease Drug Resistance †
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journal
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January 2003 |
Multidrug Resistance to HIV-1 Protease Inhibition Requires Cooperative Coupling between Distal Mutations
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journal
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October 2003 |
Comparing the Accumulation of Active- and Nonactive-Site Mutations in the HIV-1 Protease
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journal
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August 2004 |
Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody
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journal
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January 2019 |
Interdependence of Inhibitor Recognition in HIV-1 Protease
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journal
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April 2017 |
Drug Resistance Conferred by Mutations Outside the Active Site through Alterations in the Dynamic and Structural Ensemble of HIV-1 Protease
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journal
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August 2014 |
Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease
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journal
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September 2016 |
Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease
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journal
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October 2018 |
Human immunodeficiency virus reverse transcriptase and protease sequence database
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journal
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January 2003 |
Rationale and Uses of a Public HIV Drug‐Resistance Database
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journal
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September 2006 |
Elucidating the Interdependence of Drug Resistance from Combinations of Mutations
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journal
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October 2017 |
Context Surrounding Processing Sites Is Crucial in Determining Cleavage Rate of a Subset of Processing Sites in HIV-1 Gag and Gag-Pro-Pol Polyprotein Precursors by Viral Protease
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journal
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April 2012 |
Transient HIV-1 Gag–protease interactions revealed by paramagnetic NMR suggest origins of compensatory drug resistance mutations
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journal
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October 2016 |
Fluorogenic Assay for Inhibitors of HIV-1 Protease with Sub-picomolar Affinity
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journal
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August 2015 |
Structural and Thermodynamic Basis for the Binding of TMC114, a Next-Generation Human Immunodeficiency Virus Type 1 Protease Inhibitor
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journal
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October 2004 |
Double-mutant cycles: a powerful tool for analyzing protein structure and function
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journal
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December 1996 |
Defective Hydrophobic Sliding Mechanism and Active Site Expansion in HIV-1 Protease Drug Resistant Variant Gly48Thr/Leu89Met: Mechanisms for the Loss of Saquinavir Binding Potency
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journal
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December 2014 |
Hydrophobic Sliding: A Possible Mechanism for Drug Resistance in Human Immunodeficiency Virus Type 1 Protease
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journal
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February 2007 |
Improving the Resistance Profile of Hepatitis C NS3/4A Inhibitors: Dynamic Substrate Envelope Guided Design
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journal
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November 2013 |
Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy
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journal
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January 1999 |
Interaction of I50V Mutant and I50L/A71V Double Mutant HIV-Protease with Inhibitor TMC114 (Darunavir): Molecular Dynamics Simulation and Binding Free Energy Studies
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journal
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February 2012 |
Comparing Conformational Ensembles Using the Kullback–Leibler Divergence Expansion
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journal
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May 2012 |
Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease
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journal
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October 2014 |
Regulation of autoproteolysis of the HIV-1 and HIV-2 proteases with engineered amino acid substitutions
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journal
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June 1993 |
Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease
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journal
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February 2002 |
Large scale purification and refolding of HIV-1 protease fromEscherichia coli inclusion bodies
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journal
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June 1993 |
Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer
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journal
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February 1990 |
Use of a Fluorescence Plate Reader for Measuring Kinetic Parameters with Inner Filter Effect Correction
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journal
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February 1999 |
[20] Processing of X-ray diffraction data collected in oscillation mode
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book
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January 1997 |
Phaser crystallographic software
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journal
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July 2007 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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journal
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January 2010 |
electronic Ligand Builder and Optimization Workbench ( eLBOW ): a tool for ligand coordinate and restraint generation
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journal
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September 2009 |
Free R value: a novel statistical quantity for assessing the accuracy of crystal structures
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journal
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January 1992 |
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids
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journal
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May 2007 |
Mechanism of Substrate Recognition by Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variants Revealed by a Novel Structural Intermediate
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journal
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April 2006 |
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
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journal
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March 2013 |
Development and Testing of the OPLS All-Atom Force Field on Conformational Energetics and Properties of Organic Liquids
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journal
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January 1996 |
Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance
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journal
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March 2010 |
Hydration Structure and Dynamics of Inhibitor-Bound HIV-1 Protease
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journal
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March 2018 |
On the Role of the Crystal Environment in Determining Protein Side-chain Conformations
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journal
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July 2002 |
PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical p K a Predictions
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journal
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December 2010 |
Improved Treatment of Ligands and Coupling Effects in Empirical Calculation and Rationalization of p K a Values
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journal
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June 2011 |
Integrated Modeling Program, Applied Chemical Theory (IMPACT)
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journal
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January 2005 |
Scalable Algorithms for Molecular Dynamics Simulations on Commodity Clusters
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conference
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November 2006 |
Dynamics of Preferential Substrate Recognition in HIV-1 Protease: Redefining the Substrate Envelope
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journal
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July 2011 |