Reduction-dependent siderophore assimilation in a model pennate diatom

Coale, Tyler H.; Moosburner, Mark; Horák, Aleš; Oborník, Miroslav; Barbeau, Katherine A.; Allen, Andrew E.

doi:10.1073/pnas.1907234116

Title: Reduction-dependent siderophore assimilation in a model pennate diatom

Journal Article · Mon Nov 04 00:00:00 EST 2019 · Proceedings of the National Academy of Sciences of the United States of America

DOI:https://doi.org/10.1073/pnas.1907234116· OSTI ID:1573107

^[1]; Moosburner, Mark ^[1]; Horák, Aleš ^[2]; Oborník, Miroslav ^[2]; Barbeau, Katherine A. ^[3];

^[1]

Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093,, Microbial and Environmental Genomics, J. Craig Venter Institute, La Jolla, CA 92037,
Biology Centre, Institute of Parasitology, Academy of Sciences of the Czech Republic, 370 05 České Budějovice, Czech Republic,, Faculty of Science, University of South Bohemia, 370 05 České Budějovice, Czech Republic
Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093,

Iron uptake by diatoms is a biochemical process with global biogeochemical implications. In large regions of the surface ocean diatoms are both responsible for the majority of primary production and frequently experiencing iron limitation of growth. The strategies used by these phytoplankton to extract iron from seawater constrain carbon flux into higher trophic levels and sequestration into sediments. In this study we use reverse genetic techniques to target putative iron-acquisition genes in the model pennate diatom Phaeodactylum tricornutum. We describe components of a reduction-dependent siderophore acquisition pathway that relies on a bacterial-derived receptor protein and provides a viable alternative to inorganic iron uptake under certain conditions. This form of iron uptake entails a close association between diatoms and siderophore-producing organisms during low-iron conditions. Homologs of these proteins are found distributed across diatom lineages, suggesting the significance of siderophore utilization by diatoms in the marine environment. Evaluation of specific proteins enables us to confirm independent iron-acquisition pathways in diatoms and characterize their preferred substrates. These findings refine our mechanistic understanding of the multiple iron-uptake systems used by diatoms and help us better predict the influence of iron speciation on taxa-specific iron bioavailability.

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Research Organization:: J. Craig Venter Institute, Inc., Rockville, MD (United States)

Sponsoring Organization:: USDOE Office of Science (SC); National Science Foundation (NSF); Gordon and Betty Moore Foundation; Czech Science Foundation; European Regional Development Fund/European Social Fund

Grant/Contract Number:: SC0018344; NSF-OCE-1756884; NSF-OCE-1756860; NSF-MCB-1818390; GBMF3828; GBMF5006; 18-13458S; CZ.02.1.01/0.0/0.0/16_019/0000759

OSTI ID:: 1573107

Alternate ID(s):: OSTI ID: 1625043

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Journal Name: Proceedings of the National Academy of Sciences of the United States of America Vol. 116 Journal Issue: 47; ISSN 0027-8424

Publisher:: Proceedings of the National Academy of SciencesCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 34 works

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59 BASIC BIOLOGICAL SCIENCES
science & technology - other topics
diatom
iron acquisition
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siderophore
phytoplankton

Title: Reduction-dependent siderophore assimilation in a model pennate diatom

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