Laser-Induced CO₂ Generation from Gold Nanorod-Containing Poly(propylene carbonate)-Based Block Polymer Micelles for Ultrasound Contrast Enhancement

Journal Article · Mon Jul 16 00:00:00 EDT 2018 · ACS Applied Materials and Interfaces

DOI:https://doi.org/10.1021/acsami.8b09630· OSTI ID:1572974

Lee, Jaewon ^[1]; Jo, Sung Duk ^[2]; Chung, Haejun ^[3]; Um, Wooram ^[2]; Chandrasekar, Rohith ^[3]; Choi, Yun Hwa ^[3]; Shalaev, Vladimir M. ^[3]; Won, You-Yeon ^[4]

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1. Purdue Univ., West Lafayette, IN (United States); Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
2. Korea Inst. of Science and Technology (KIST), Seoul (South Korea)
3. Purdue Univ., West Lafayette, IN (United States)
4. Purdue Univ., West Lafayette, IN (United States); Korea Inst. of Science and Technology (KIST), Seoul (South Korea); Purdue University Center for Cancer Research, West Lafayette, IN (United States)

Poly(propylene carbonate) (PPC) decomposes at high temperature to release CO₂. Here, this CO₂-generation temperature of PPC can be reduced down to less than 80 °C with the aid of a photoacid generator (PAG). In the present work, we demonstrate that using an additional helper component, surface plasmonic gold nanorods (GNRs), the PPC degradation reaction can also be initiated by near infrared (NIR) irradiation. For this purpose, a PPC-containing nanoparticle formulation was developed in which PPC-based amphiphilic block copolymers (BCPs), poly(poly(ethylene glycol) methacrylate-b-propylene carbonate-b-poly(ethylene glycol) methacrylate) (PPEGMA-PPC-PPEGMA), were self-assembled with GNRs and PAG molecules via solvent exchange; under NIR irradiation GNRs produce heat that can cause PPC to decompose into CO₂, and PAG (after UV pre-treatment) catalyzes this PPC degradation process.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• Grant/Contract Number: AC05-76RL01830
• OSTI ID: 1572974
• Report Number(s): PNNL-SA--136641
• Journal Information: ACS Applied Materials and Interfaces, Journal Name: ACS Applied Materials and Interfaces Journal Issue: 31 Vol. 10; ISSN 1944-8244
• Publisher: American Chemical Society (ACS)
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
IR irradiation
block copolymer
gas-generating nanoparticle
gold nanorod
photoacid generator
plasmonic heat generation
poly(propylene carbonate)
ultrasound contrast