A multiomics focusing towards the molecular networks of lung development

Clair, Geremy

doi:10.1152/ajplung.00364.2019

A multiomics focusing towards the molecular networks of lung development

Journal Article · Mon Oct 28 00:00:00 EDT 2019 · The American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI:https://doi.org/10.1152/ajplung.00364.2019· OSTI ID:1572899

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Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

At the end of the first month of embryonic development, a patch of cells of the foregut starts to express the transcription factor NKX2.1. This singular event is the inception of a cascade of molecular processes that ultimately will lead to the formation of mature lungs. The lungs are heterogeneous both from a structural and a cellular standpoint. The formation of its elegant branched and alveolar structures requires a plethora of molecular and cellular events to happen. Elucidating the orchestration of lung development is critical to reveal the underlying causes of a wide range of chronic and acute respiratory diseases. The exploration of lung organogenesis may allow us, someday, to fight diseases and to regenerate injured lungs. The appearance and the democratization of omics technologies have empowered scientists and clinicians with broad and fast tools to explore developmental biology. The number of omics datasets describing lung organogenesis is continuously growing. At each new generation, omics technologies are faster, more sensitive, and more accurate, thus depicting in more vivid details the biological processes at play.

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1572899

Report Number(s):: PNNL-SA-147553

Journal Information:: The American Journal of Physiology-Lung Cellular and Molecular Physiology, Journal Name: The American Journal of Physiology-Lung Cellular and Molecular Physiology Journal Issue: 5 Vol. 317; ISSN 1040-0605

Publisher:: American Physiological SocietyCopyright Statement

Country of Publication:: United States

Language:: English

References (11)

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