Crossover from picosecond collective to single particle dynamics defines the mechanism of lateral lipid diffusion

Bolmatov, Dima; Cai, Yong Q.; Zav’yalov, Dmitry; Zhernenkov, Mikhail

doi:10.1016/j.bbamem.2018.07.004

Title: Crossover from picosecond collective to single particle dynamics defines the mechanism of lateral lipid diffusion

Journal Article · Thu Nov 01 00:00:00 EDT 2018 · Biochimica et Biophysica Acta. Biomembranes

DOI:https://doi.org/10.1016/j.bbamem.2018.07.004· OSTI ID:1572744

Bolmatov, Dima; Cai, Yong Q.; Zav’yalov, Dmitry; Zhernenkov, Mikhail

It has been widely accepted that the thermally excited motions of the molecules in a cell membrane is the prerequisite for a cell to carry its biological functions. On the other hand, the detailed mapping of the ultrafast picosecond single-molecule and the collective lipid dynamics in a cell membrane remains rather elusive. Here, we report all-atom molecular dynamics simulations of a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine bilayer over a wide range of temperature. We elucidate a molecular mechanism underlying the lateral lipid diffusion in a cell membrane across the gel, rippled, and liquid phases using an analysis of the longitudinal and transverse current correlation spectra, the velocity auto-correlation functions, and the molecules mean square displacements. The molecular mechanism is based on the anomalous ultrafast vibrational properties of lipid molecules at the viscous-to-elastic crossover. The macroscopic lipid diffusion coefficients predicted by the proposed diffusion model are in a good agreement with experimentally observed values. Moreover, we unveil the role of water confined at the water-lipid interface in triggering collective vibrations in a lipid bilayer.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0012704

OSTI ID:: 1572744

Alternate ID(s):: OSTI ID: 1482560

Report Number(s):: BNL-209459-2018-JAAM; S0005273618301998; PII: S0005273618301998

Journal Information:: Biochimica et Biophysica Acta. Biomembranes, Journal Name: Biochimica et Biophysica Acta. Biomembranes Vol. 1860 Journal Issue: 11; ISSN 0005-2736

Publisher:: ElsevierCopyright Statement

Country of Publication:: Netherlands

Language:: English

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Cited by: 16 works

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