Observing the colloidal stability of iron oxide nanoparticles in situ

Hufschmid, Ryan D.; Teeman, Eric M.; Mehdi, Beata L.; Krishnan, Krishnan M.; Browning, Nigel D.

doi:10.1039/c9nr03709h

Observing the colloidal stability of iron oxide nanoparticles in situ

Journal Article · 21 July 2019 · Nanoscale

DOI:https://doi.org/10.1039/c9nr03709h· OSTI ID:1571273

Hufschmid, Ryan D. ^[1]; Teeman, Eric M. ^[1]; Mehdi, Beata L. ^[2]; Krishnan, Krishnan M. ^[1]; ^[2]

UNIVERSITY OF WASHINGTON
UNIVERSITY OF LIVERPOOL (J. APPOINTMENT)

Colloidal processes such as nucleation, growth, ripening, and dissolution are fundamental to the synthesis and application of engineered nanoparticles, as well as numerous natural systems. In nanocolloids consisting of a dispersion of nanoparticles in solution, colloidal stability is in?uenced by factors including the particle surface facet and capping layer, and local temperature, chemistry, and acidity. In this paper, we investigate colloidal stability through the real-time manipulation of nanoparticles using in situ liquid cell Scanning Transmission Electron Microscopy (STEM). In a distribution of uniform iron oxide nanoparticles, we use the electron beam to precisely control the local chemistry of the solution and observe the critical role that surface chemistry plays in nanoparticle stability. By functionalizing the nanoparticle surfaces with charged amino acids and peptides, stability can be tuned to promote dissolution, growth, or agglomeration, either permanently or reversibly. STEM imaging is used to quantify kinetics of individual nanoparticles subject to local variations in chemistry. These measurements of dissolution and growth rates of iron oxide nanoparticles provide insights into nanoparticle stability relevant to synthesis and functionalization for biomedical applications.

Research Organization:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RL01830

OSTI ID:: 1571273

Report Number(s):: PNNL-SA-147663

Journal Information:: Nanoscale, Vol. 11, Issue 27

Country of Publication:: United States

Language:: English

References (64)

Biomimetic Pathways for Assembling Inorganic Thin Films Aksay, I. A.; Trau, M.; Manne, S. Science, Vol. 273, Issue 5277 https://doi.org/10.1126/science.273.5277.892	journal	August 1996
Direct mapping of the solid–liquid adhesion energy with subnanometre resolution Voïtchovsky, Kislon; Kuna, Jeffrey J.; Contera, Sonia Antoranz Nature Nanotechnology, Vol. 5, Issue 6 https://doi.org/10.1038/nnano.2010.67	journal	April 2010
Direct Visualization of Aggregate Morphology and Dynamics in a Model Soil Organic–Mineral System Hufschmid, Ryan; Newcomb, Christina J.; Grate, Jay W. Environmental Science & Technology Letters, Vol. 4, Issue 5 https://doi.org/10.1021/acs.estlett.7b00068	journal	April 2017
Real-time single-molecule imaging of oxidation catalysis at a liquid–solid interface Hulsken, Bas; Van Hameren, Richard; Gerritsen, Jan W. Nature Nanotechnology, Vol. 2, Issue 5 https://doi.org/10.1038/nnano.2007.106	journal	April 2007
Angstrom-Resolved Real-Time Dissection of Electrochemically Active Noble Metal Interfaces Shrestha, Buddha R.; Baimpos, Theodoros; Raman, Sangeetha ACS Nano, Vol. 8, Issue 6 https://doi.org/10.1021/nn501127n	journal	May 2014
Rational design of efficient electrode–electrolyte interfaces for solid-state energy storage using ion soft landing Prabhakaran, Venkateshkumar; Mehdi, B. Layla; Ditto, Jeffrey J. Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms11399	journal	April 2016
Understanding biophysicochemical interactions at the nano–bio interface Nel, Andre E.; Mädler, Lutz; Velegol, Darrell Nature Materials, Vol. 8, Issue 7 https://doi.org/10.1038/nmat2442	journal	June 2009
Biomedical Nanomagnetics: A Spin Through Possibilities in Imaging, Diagnostics, and Therapy Krishnan, Kannan M. IEEE Transactions on Magnetics, Vol. 46, Issue 7 https://doi.org/10.1109/TMAG.2010.2046907	journal	July 2010
Interfacing Engineered Nanoparticles with Biological Systems: Anticipating Adverse Nano-Bio Interactions Pelaz, Beatriz; Charron, Gaëlle; Pfeiffer, Christian Small, Vol. 9, Issue 9-10 https://doi.org/10.1002/smll.201201229	journal	October 2012
The Challenge To Relate the Physicochemical Properties of Colloidal Nanoparticles to Their Cytotoxicity Rivera-Gil, Pilar; Jimenez De Aberasturi, Dorleta; Wulf, Verena Accounts of Chemical Research, Vol. 46, Issue 3 https://doi.org/10.1021/ar300039j	journal	July 2012
The One Year Fate of Iron Oxide Coated Gold Nanoparticles in Mice Kolosnjaj-Tabi, Jelena; Javed, Yasir; Lartigue, Lénaic ACS Nano, Vol. 9, Issue 8 https://doi.org/10.1021/acsnano.5b00042	journal	July 2015
In vivo degeneration and the fate of inorganic nanoparticles Feliu, Neus; Docter, Dominic; Heine, Markus Chemical Society Reviews, Vol. 45, Issue 9 https://doi.org/10.1039/C5CS00699F	journal	January 2016
Nucleation and growth of magnetite from solution Baumgartner, Jens; Dey, Archan; Bomans, Paul H. H. Nature Materials, Vol. 12, Issue 4 https://doi.org/10.1038/nmat3558	journal	February 2013
Ultra-large-scale syntheses of monodisperse nanocrystals Park, Jongnam; An, Kwangjin; Hwang, Yosun Nature Materials, Vol. 3, Issue 12 https://doi.org/10.1038/nmat1251	journal	November 2004
Alternative low-cost approach to the synthesis of magnetic iron oxide nanoparticles by thermal decomposition of organic precursors Perez De Berti, I. O.; Cagnoli, M. V.; Pecchi, G. Nanotechnology, Vol. 24, Issue 17 https://doi.org/10.1088/0957-4484/24/17/175601	journal	April 2013
In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles Arami, Hamed; Khandhar, Amit; Liggitt, Denny Chemical Society Reviews, Vol. 44, Issue 23 https://doi.org/10.1039/C5CS00541H	journal	January 2015
Intracellular dynamics of superparamagnetic iron oxide nanoparticles for magnetic particle imaging Teeman, Eric; Shasha, Carolyn; Evans, James E. Nanoscale, Vol. 11, Issue 16 https://doi.org/10.1039/C9NR01395D	journal	January 2019
Superparamagnetic iron oxide: pharmacokinetics and toxicity Weissleder, R.; Stark, Dd; Engelstad, Bl American Journal of Roentgenology, Vol. 152, Issue 1 https://doi.org/10.2214/ajr.152.1.167	journal	January 1989
A model of lysosomal metabolism of dextran coated superparamagnetic iron oxide (SPIO) nanoparticles: implications for cellular magnetic resonance imaging Arbab, Ali S.; Wilson, Lindsey B.; Ashari, Parwana NMR in Biomedicine, Vol. 18, Issue 6 https://doi.org/10.1002/nbm.970	journal	October 2005
Long term in vivo biotransformation of iron oxide nanoparticles Levy, Michael; Luciani, Nathalie; Alloyeau, Damien Biomaterials, Vol. 32, Issue 16 https://doi.org/10.1016/j.biomaterials.2011.02.031	journal	June 2011
Biodegradation of Iron Oxide Nanocubes: High-Resolution In Situ Monitoring Lartigue, Lénaic; Alloyeau, Damien; Kolosnjaj-Tabi, Jelena ACS Nano, Vol. 7, Issue 5 https://doi.org/10.1021/nn305719y	journal	May 2013
In vivo multimodal magnetic particle imaging (MPI) with tailored magneto/optical contrast agents Arami, Hamed; Khandhar, Amit P.; Tomitaka, Asahi Biomaterials, Vol. 52 https://doi.org/10.1016/j.biomaterials.2015.02.040	journal	June 2015
Water dispersible iron oxide nanoparticles coated with covalently linked chitosan López-Cruz, Alejandro; Barrera, Carola; Calero-DdelC, Victoria L. Journal of Materials Chemistry, Vol. 19, Issue 37 https://doi.org/10.1039/b908777j	journal	January 2009
Functionalization of magnetic nanoparticles with peptide dendrimers Zhu, Rong; Jiang, Wen; Pu, Yuji Journal of Materials Chemistry, Vol. 21, Issue 14 https://doi.org/10.1039/c0jm02752a	journal	January 2011
Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling Soenen, Stefaan J. H.; Himmelreich, Uwe; Nuytten, Nele Biomaterials, Vol. 32, Issue 1 https://doi.org/10.1016/j.biomaterials.2010.08.075	journal	January 2011
The role of iron redox state in the genotoxicity of ultrafine superparamagnetic iron oxide nanoparticles Singh, Neenu; Jenkins, Gareth J. S.; Nelson, Bryant C. Biomaterials, Vol. 33, Issue 1 https://doi.org/10.1016/j.biomaterials.2011.09.087	journal	January 2012
Nature of Interactions of Amino Acids with Bare Magnetite Nanoparticles Schwaminger, Sebastian P.; García, Paula Fraga; Merck, Georg K. The Journal of Physical Chemistry C, Vol. 119, Issue 40 https://doi.org/10.1021/acs.jpcc.5b07195	journal	September 2015
Accelerated Iron Oxide Nanoparticle Degradation Mediated by Polyester Encapsulation within Cellular Spheroids Mattix, Brandon; Olsen, Timothy R.; Moore, Thomas Advanced Functional Materials, Vol. 24, Issue 6 https://doi.org/10.1002/adfm.201301736	journal	September 2013
LI. A contribution to the theory of electrocapillarity Chapman, David Leonard The London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science, Vol. 25, Issue 148 https://doi.org/10.1080/14786440408634187	journal	April 1913
Nanostructure of the Ionic Liquid–Graphite Stern Layer Elbourne, Aaron; McDonald, Samila; Voïchovsky, Kislon ACS Nano, Vol. 9, Issue 7 https://doi.org/10.1021/acsnano.5b02921	journal	June 2015
Bias-Dependent Molecular-Level Structure of Electrical Double Layer in Ionic Liquid on Graphite Black, Jennifer M.; Walters, Deron; Labuda, Aleksander Nano Letters, Vol. 13, Issue 12, p. 5954-5960 https://doi.org/10.1021/nl4031083	journal	November 2013
Understanding the Role of Solvation Forces on the Preferential Attachment of Nanoparticles in Liquid Welch, David A.; Woehl, Taylor J.; Park, Chiwoo ACS Nano, Vol. 10, Issue 1 https://doi.org/10.1021/acsnano.5b06632	journal	December 2015
Molecular dynamics simulations of nanoparticles Tian, Pu Annual Reports Section "C" (Physical Chemistry), Vol. 104 https://doi.org/10.1039/b703897f	journal	January 2008
Direct observation of ionic structure at solid-liquid interfaces: a deep look into the Stern Layer Siretanu, Igor; Ebeling, Daniel; Andersson, Martin P. Scientific Reports, Vol. 4, Issue 1 https://doi.org/10.1038/srep04956	journal	May 2014
Nanosecond time-resolved investigations using the in situ of dynamic transmission electron microscope (DTEM) LaGrange, Thomas; Campbell, Geoffrey H.; Reed, B. W. Ultramicroscopy, Vol. 108, Issue 11, p. 1441-1449 https://doi.org/10.1016/j.ultramic.2008.03.013	journal	October 2008
Real-time observations with electron microscopy Stach, Eric A. Materials Today, Vol. 11 https://doi.org/10.1016/S1369-7021(09)70007-0	journal	January 2008
Dynamic microscopy of nanoscale cluster growth at the solid–liquid interface Williamson, M. J.; Tromp, R. M.; Vereecken, P. M. Nature Materials, Vol. 2, Issue 8 https://doi.org/10.1038/nmat944	journal	July 2003
Electron microscopy of specimens in liquid de Jonge, Niels; Ross, Frances M. Nature Nanotechnology, Vol. 6, Issue 11, p. 695-704 https://doi.org/10.1038/nnano.2011.161	journal	October 2011
In situ liquid-cell electron microscopy of colloid aggregation and growth dynamics Grogan, Joseph M.; Rotkina, Lolita; Bau, Haim H. Physical Review E, Vol. 83, Issue 6 https://doi.org/10.1103/PhysRevE.83.061405	journal	June 2011
Factors influencing quantitative liquid (scanning) transmission electron microscopy Abellan, P.; Woehl, T. J.; Parent, L. R. Chem. Commun., Vol. 50, Issue 38 https://doi.org/10.1039/C3CC48479C	journal	January 2014
Environmental high resolution electron microscopy and applications to chemical science Boyes, E. D.; Gai, P. L. Ultramicroscopy, Vol. 67, Issue 1-4 https://doi.org/10.1016/S0304-3991(96)00099-X	journal	June 1997
Atomic-scale electron microscopy at ambient pressure Creemer, J. F.; Helveg, S.; Hoveling, G. H. Ultramicroscopy, Vol. 108, Issue 9 https://doi.org/10.1016/j.ultramic.2008.04.014	journal	August 2008
Effects of size on the mechanical response of metallic glasses investigated through in situ TEM bending and compression experiments Chen, C. Q.; Pei, Y. T.; De Hosson, J. T. M. Acta Materialia, Vol. 58, Issue 1 https://doi.org/10.1016/j.actamat.2009.08.070	journal	January 2010
Beitrag zur �bermikroskopischen Abbildung bei h�heren Drucken Ruska, E. Kolloid-Zeitschrift, Vol. 100, Issue 2 https://doi.org/10.1007/BF01519549	journal	August 1942
Observation of Single Colloidal Platinum Nanocrystal Growth Trajectories Zheng, H.; Smith, R. K.; Jun, Y. -w. Science, Vol. 324, Issue 5932 https://doi.org/10.1126/science.1172104	journal	June 2009
Direct in Situ Determination of the Mechanisms Controlling Nanoparticle Nucleation and Growth Woehl, Taylor J.; Evans, James E.; Arslan, Ilke ACS Nano, Vol. 6, Issue 10 https://doi.org/10.1021/nn303371y	journal	September 2012
Direct in Situ Observation of Nanoparticle Synthesis in a Liquid Crystal Surfactant Template Parent, Lucas R.; Robinson, David B.; Woehl, Taylor J. ACS Nano, Vol. 6, Issue 4 https://doi.org/10.1021/nn300671g	journal	March 2012
Electron beam induced chemistry of gold nanoparticles in saline solution Hermannsdörfer, J.; de Jonge, N.; Verch, A. Chemical Communications, Vol. 51, Issue 91 https://doi.org/10.1039/C5CC06812F	journal	January 2015
In Situ Observation of the Electrochemical Lithiation of a Single SnO₂ Nanowire Electrode Huang, J. Y.; Zhong, L.; Wang, C. M. Science, Vol. 330, Issue 6010, p. 1515-1520 https://doi.org/10.1126/science.1195628	journal	December 2010
Observation and Quantification of Nanoscale Processes in Lithium Batteries by Operando Electrochemical (S)TEM Mehdi, B. L.; Qian, J.; Nasybulin, E. Nano Letters, Vol. 15, Issue 3 https://doi.org/10.1021/acs.nanolett.5b00175	journal	February 2015
In Situ TEM Study of Lithiation Behavior of Silicon Nanoparticles Attached to and Embedded in a Carbon Matrix Gu, Meng; Li, Ying; Li, Xiaolin ACS Nano, Vol. 6, Issue 9 https://doi.org/10.1021/nn303312m	journal	August 2012
Electron–Water Interactions and Implications for Liquid Cell Electron Microscopy Schneider, Nicholas M.; Norton, Michael M.; Mendel, Brian J. The Journal of Physical Chemistry C, Vol. 118, Issue 38 https://doi.org/10.1021/jp507400n	journal	September 2014
Synthesis of phase-pure and monodisperse iron oxide nanoparticles by thermal decomposition Hufschmid, Ryan; Arami, Hamed; Ferguson, R. Matthew Nanoscale, Vol. 7, Issue 25 https://doi.org/10.1039/C5NR01651G	journal	January 2015
Monodisperse magnetite nanoparticles with nearly ideal saturation magnetization Kemp, Scott J.; Ferguson, R. Matthew; Khandhar, Amit P. RSC Advances, Vol. 6, Issue 81 https://doi.org/10.1039/C6RA12072E	journal	January 2016
Phase transfer of highly monodisperse iron oxide nanocrystals with Pluronic F127 for biomedical applications Gonzales, Marcela; Krishnan, Kannan M. Journal of Magnetism and Magnetic Materials, Vol. 311, Issue 1 https://doi.org/10.1016/j.jmmm.2006.10.1150	journal	April 2007
Aqueous dispersion of monodisperse magnetic iron oxide nanocrystals through phase transfer Yu, William W.; Chang, Emmanuel; Sayes, Christie M. Nanotechnology, Vol. 17, Issue 17 https://doi.org/10.1088/0957-4484/17/17/033	journal	August 2006
Z-contrast stem for materials science Pennycook, S. J. Ultramicroscopy, Vol. 30, Issue 1-2 https://doi.org/10.1016/0304-3991(89)90173-3	journal	June 1989
Tuning Surface Coatings of Optimized Magnetite Nanoparticle Tracers for In Vivo Magnetic Particle Imaging Khandhar, Amit P.; Ferguson, R. Matthew; Arami, Hamed IEEE Transactions on Magnetics, Vol. 51, Issue 2 https://doi.org/10.1109/TMAG.2014.2321096	journal	February 2015
Measurements of particle size distribution parameters in ferrofluids Chantrell, R.; Popplewell, J.; Charles, S. IEEE Transactions on Magnetics, Vol. 14, Issue 5 https://doi.org/10.1109/TMAG.1978.1059918	journal	September 1978
Atomic-resolution chemical analysis using a scanning transmission electron microscope Browning, N. D.; Chisholm, M. F.; Pennycook, S. J. Nature, Vol. 366, Issue 6451 https://doi.org/10.1038/366143a0	journal	November 1993
Factors Governing the Protonation State of Cysteines in Proteins: An Ab Initio/CDM Study Dudev, Todor; Lim, Carmay Journal of the American Chemical Society, Vol. 124, Issue 23 https://doi.org/10.1021/ja012620l	journal	June 2002
An Investigation on the Equilibria between Arginine and Iron(II) and Iron(III) Bottari, Emilio; Festa, Maria Rosa; Gentile, Lorella Journal of Chemical & Engineering Data, Vol. 58, Issue 3 https://doi.org/10.1021/je301217e	journal	February 2013
The Oxidation of cysteine by Iron and Hydrogen Peroxide Neville, Roy G. Journal of the American Chemical Society, Vol. 79, Issue 10 https://doi.org/10.1021/ja01567a028	journal	May 1957
High-Resolution Electron Microscopy and Spectroscopy of Ferritin in Biocompatible Graphene Liquid Cells and Graphene Sandwiches Wang, Canhui; Qiao, Qiao; Shokuhfar, Tolou Advanced Materials, Vol. 26, Issue 21 https://doi.org/10.1002/adma.201306069	journal	February 2014

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