Observing the colloidal stability of iron oxide nanoparticles in situ

Hufschmid, Ryan D.; Teeman, Eric M.; Mehdi, Beata L.; Krishnan, Krishnan M.; Browning, Nigel D.

doi:10.1039/c9nr03709h

Observing the colloidal stability of iron oxide nanoparticles in situ

Journal Article · Sun Jul 21 04:00:00 EDT 2019 · Nanoscale

DOI:https://doi.org/10.1039/c9nr03709h· OSTI ID:1571273

Hufschmid, Ryan D. ^[1]; Teeman, Eric M. ^[1]; Mehdi, Beata L. ^[2]; Krishnan, Krishnan M. ^[1]; ^[2]

UNIVERSITY OF WASHINGTON
UNIVERSITY OF LIVERPOOL (J. APPOINTMENT)

Colloidal processes such as nucleation, growth, ripening, and dissolution are fundamental to the synthesis and application of engineered nanoparticles, as well as numerous natural systems. In nanocolloids consisting of a dispersion of nanoparticles in solution, colloidal stability is in?uenced by factors including the particle surface facet and capping layer, and local temperature, chemistry, and acidity. In this paper, we investigate colloidal stability through the real-time manipulation of nanoparticles using in situ liquid cell Scanning Transmission Electron Microscopy (STEM). In a distribution of uniform iron oxide nanoparticles, we use the electron beam to precisely control the local chemistry of the solution and observe the critical role that surface chemistry plays in nanoparticle stability. By functionalizing the nanoparticle surfaces with charged amino acids and peptides, stability can be tuned to promote dissolution, growth, or agglomeration, either permanently or reversibly. STEM imaging is used to quantify kinetics of individual nanoparticles subject to local variations in chemistry. These measurements of dissolution and growth rates of iron oxide nanoparticles provide insights into nanoparticle stability relevant to synthesis and functionalization for biomedical applications.

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RL01830

OSTI ID:: 1571273

Report Number(s):: PNNL-SA-147663

Journal Information:: Nanoscale, Journal Name: Nanoscale Journal Issue: 27 Vol. 11

Country of Publication:: United States

Language:: English

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