2D Crystal Engineering of Nanosheets Assembled from Helical Peptide Building Blocks

Merg, Andrea D.; Touponse, Gavin; van Genderen, Eric; Zuo, Xiaobing; Bazrafshan, Alisina; Blum, Thorsten; Hughes, Spencer; Salaita, Khalid; Abrahams, Jan Pieter; Conticello, Vincent P.

doi:10.1002/anie.201906214

2D Crystal Engineering of Nanosheets Assembled from Helical Peptide Building Blocks

Journal Article · Wed Jul 10 00:00:00 EDT 2019 · Angewandte Chemie (International Edition)

DOI:https://doi.org/10.1002/anie.201906214· OSTI ID:1569846

^[1]; Touponse, Gavin ^[1]; ^[2]; ^[3]; ^[1]; Blum, Thorsten ^[2]; Hughes, Spencer ^[1]; ^[1]; ^[4]; ^[1]

Emory Univ., Atlanta, GA (United States)
Paul Scherrer Inst. (PSI), Villigen (Switzerland)
Argonne National Lab. (ANL), Argonne, IL (United States). X-ray Science Division
Paul Scherrer Inst. (PSI), Villigen (Switzerland); Univ. of Basel (Switzerland). Center for Cellular Imaging and NanoAnalytics; Leiden Univ. (Netherlands)

The successful integration of 2D nanomaterials into functional devices hinges on developing fabrication methods that afford hierarchical control across length scales of the entire assembly. We demonstrate structural control over a class of crystalline 2D nanosheets assembled from collagen triple helices. By lengthening the triple helix unit through sequential additions of Pro-Hyp-Gly triads, we achieved sub-angstrom tuning over the 2D lattice. These subtle changes influence the overall nanosheet size, which can be adjusted across the mesoscale size regime. The internal structure was observed by cryo-TEM with direct electron detection, which provides realspace high-resolution images, in which individual triple helices comprising the lattice can be clearly discerned. These results establish a general strategy for tuning the structural hierarchy of 2D nanomaterials that employ rigid, cylindrical structural units.

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1569846

Journal Information:: Angewandte Chemie (International Edition), Journal Name: Angewandte Chemie (International Edition) Journal Issue: 38 Vol. 58; ISSN 1433-7851

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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