Towards resolving the spatial metabolome with unambiguous molecular annotations in complex biological systems by coupling mass spectrometry imaging with structures for lossless ion manipulations

Nagy, Gabe; Veličković, Dusan; Chu, Rosalie K.; Carrell, Alyssa A.; Weston, David J.; Ibrahim, Yehia M.; Anderton, Christopher R.; Smith, Richard D.

doi:10.1039/c8cc07482h

Towards resolving the spatial metabolome with unambiguous molecular annotations in complex biological systems by coupling mass spectrometry imaging with structures for lossless ion manipulations

Journal Article · Thu Dec 06 23:00:00 EST 2018 · ChemComm

DOI:https://doi.org/10.1039/c8cc07482h· OSTI ID:1560416

Nagy, Gabe ^[1]; Veličković, Dusan ^[1]; Chu, Rosalie K. ^[1]; Carrell, Alyssa A. ^[2]; ^[2]; ^[1]; ^[1]; ^[1]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

We show the coupling of liquid extraction surface analysis (LESA) to structures for lossless ion manipulations in conjunction with serpentine ultralong path with extending routing (SLIM SUPER) ion mobility-mass spectrometry (IM-MS) for the unambiguous annotation of significant isomeric glycoforms in carbon-fixing communities.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1560416

Alternate ID(s):: OSTI ID: 1484952
OSTI ID: 1496826

Journal Information:: ChemComm, Journal Name: ChemComm Journal Issue: 3 Vol. 55; ISSN CHCOFS; ISSN 1359-7345

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Carbohydrates
Liquid Extraction Surface Analysis (LESA)
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Towards resolving the spatial metabolome with unambiguous molecular annotations in complex biological systems by coupling mass spectrometry imaging with structures for lossless ion manipulations

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References (40)

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