Silver and gold doped hydroxyapatite nanocomposites for enhanced bone regeneration

Kumar, Vijay Bhooshan; Khajuria, Deepak Kumar; Karasik, David; Gedanken, Aharon

doi:10.1088/1748-605X/ab28e4

Silver and gold doped hydroxyapatite nanocomposites for enhanced bone regeneration

Journal Article · Tue Jun 11 00:00:00 EDT 2019 · Biomedical Materials

DOI:https://doi.org/10.1088/1748-605X/ab28e4· OSTI ID:1557774

^[1]; Khajuria, Deepak Kumar ^[1]; Karasik, David ^[2]; ^[1]

Bar-Ilan Univ. (Israel)
Bar-Ilan Univ. (Israel); Hebrew SeniorLife and Harvard Medical School, Boston, MA (United States)

In this work, we report the osteogenic potential of silver (Ag), gold (Au), or silver–gold doped hydroxyapatite nanoparticles (Ag-Au-HA) in zebrafish (ZF) jawbone regeneration (JBR) model. The hydroxyapatite (HA, Ca₁₀(PO₄)₆(OH)₂), Ag-HA, Au-HA, and Ag-Au-HA nanomaterials were synthesized by the co-precipitation procedure. The surface structures of Ag-HA, Au-HA, HA, and Ag-Au-HA were analysed by scanning electron microscopy, transmission-electron microscopy (TEM), x-ray diffraction, Fourier transform infrared (FTIR), UV–vis, energy dispersive x-ray spectroscopy (EDS), elemental mapping, and laser fluorescent spectroscopy. The TEM and EDS analysis confirmed that the Ag and Au are associated with the surface of HA nanoparticle. The chemical structure of HA, Ag-HA, Au-HA, and Ag-Au-HA nanoparticles was validated by FTIR and EDS analysis. We observed that Ag and Au are associated with HA nanoparticles by electrostatic, wander wall, and electrostatic and H-bonding interaction. The effect of Ag-HA, Au-HA, and Ag-Au-HA nanoparticles on bone regeneration was confirmed by ZF JBR model. The significant growth of ZF bone regeneration was observed in Ag-Au-HA nanoparticles as compared with HA, Ag-HA, and Au-HA nanoparticles. In conclusion, these results indicating a therapeutic potential of Ag-Au-HA compositions suggest these nanomaterials would be excellent for bone regeneration and fracture healing.

View Accepted Manuscript (DOE)

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 1557774

Alternate ID(s):: OSTI ID: 22895876

Report Number(s):: LA-UR--19-26190

Journal Information:: Biomedical Materials, Journal Name: Biomedical Materials Journal Issue: 5 Vol. 14; ISSN 1748-605X

Publisher:: IOP PublishingCopyright Statement

Country of Publication:: United States

Language:: English

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