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Title: Copper binding affinity of the C2B domain of synaptotagmin-1 and its potential role in the nonclassical secretion of acidic fibroblast growth factor

Journal Article · · Biochimica et Biophysica Acta. Proteins and Proteomics

Sponsoring Organization:
USDOE
Grant/Contract Number:
FG02-01ER15161
OSTI ID:
1556251
Journal Information:
Biochimica et Biophysica Acta. Proteins and Proteomics, Journal Name: Biochimica et Biophysica Acta. Proteins and Proteomics Vol. 1844 Journal Issue: 12; ISSN 1570-9639
Publisher:
ElsevierCopyright Statement
Country of Publication:
France
Language:
English
Citation Metrics:
Cited by: 3 works
Citation information provided by
Web of Science

References (62)

Fibroblast Growth Factor Prototype Release and Fibroblast Growth Factor Receptor Signaling journal January 1999
Heat shock induces the release of fibroblast growth factor 1 from NIH 3T3 cells. journal November 1992
Three distinct kinetic groupings of the synaptotagmin family: Candidate sensors for rapid and delayed exocytosis journal March 2005
Rapid Fusion of Synaptic Vesicles with Reconstituted Target SNARE Membranes journal May 2013
The intracellular translocation of the components of the fibroblast growth factor 1 release complex precedes their assembly prior to export journal July 2002
Copper Induces the Assembly of a Multiprotein Aggregate Implicated in the Release of Fibroblast Growth Factor 1 in Response to Stress journal January 2001
Common and Distinct Elements in Cellular Signaling via EGF and FGF Receptors journal November 2004
Release of FGF1 and p40 synaptotagmin 1 correlates with their membrane destabilizing ability journal October 2006
An Annexin 2 Phosphorylation Switch Mediates p11-dependent Translocation of Annexin 2 to the Cell Surface journal October 2004
Negative Coupling as a Mechanism for Signal Propagation between C2 Domains of Synaptotagmin I journal October 2012
Protein-Phospholipid Interactions in Nonclassical Protein Secretion: Problem and Methods of Study journal February 2013
Energetics-based Protein Profiling on a Proteomic Scale: Identification of Proteins Resistant to Proteolysis journal May 2007
Copper Chaperone Antioxidant Protein1 Is Essential for Copper Homeostasis journal May 2012
Interaction of Synaptotagmin with Lipid Bilayers, Analyzed by Single-Molecule Force Spectroscopy journal October 2010
The C2A Domain of Synaptotagmin Exhibits a High Binding Affinity for Copper:  Implications in the Formation of the Multiprotein FGF Release Complex journal November 2005
Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment journal May 2013
Phosphatidylinositol 4,5-bisphosphate regulates SNARE-dependent membrane fusion journal July 2008
Fusion pore formation and expansion induced by Ca 2+ and synaptotagmin 1 journal January 2013
The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway journal August 2008
The C2 Domains of Human Synaptotagmin 1 Have Distinct Mechanical Properties journal February 2009
Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease journal October 2010
The non-classical export routes: FGF1 and IL-1α point the way journal December 2003
Partial Proteolysis of Simian Virus 40 T Antigen Reveals Intramolecular Contacts between Domains and Conformation Changes upon Hexamer Assembly journal September 2004
The PIP2 binding mode of the C2 domains of rabphilin-3A journal June 2008
Membrane-Bound Orientation and Position of the Synaptotagmin C2B Domain Determined by Site-Directed Spin Labeling journal January 2005
The Extravesicular Domain of Synaptotagmin-1 Is Released with the Latent Fibroblast Growth Factor-1 Homodimer in Response to Heat Shock journal August 1998
The alternative translation of synaptotagmin 1 mediates the non-classical release of FGF1 journal October 2003
ZIP8 Is an Iron and Zinc Transporter Whose Cell-surface Expression Is Up-regulated by Cellular Iron Loading* journal October 2012
Structure/Function Analysis of Ca 2+ Binding to the C 2 A Domain of Synaptotagmin 1 journal October 2002
Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation journal June 2011
Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum-Golgi complex journal April 1992
Interplay between glutathione, Atx1 and copper. 1. Copper(I) glutathionate induced dimerization of Atx1 journal October 2007
Fibroblast Growth Factors as Multifunctional Signaling Factors book January 1998
Molecular machines governing exocytosis of synaptic vesicles journal October 2012
The Ca 2+ Affinity of Synaptotagmin 1 Is Markedly Increased by a Specific Interaction of Its C2B Domain with Phosphatidylinositol 4,5-Bisphosphate journal July 2009
Calcium-dependent and -independent interactions of the S100 protein family journal May 2006
The Interaction between Thermodynamic Stability and Buried Free Cysteines in Regulating the Functional Half-Life of Fibroblast Growth Factor-1 journal October 2009
An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II. journal August 1994
The C2 domains of synaptotagmin – partners in exocytosis journal March 2004
Metal Ion Chaperone Function of the Soluble Cu(I) Receptor Atx1 journal October 1997
Synaptotagmin-1 Is Required for Fibroblast Growth Factor-1 Release journal August 1998
The Activation of Exocytotic Sites by the Formation of Phosphatidylinositol 4,5-Bisphosphate Microdomains at Syntaxin Clusters journal April 2005
Phosphatidylinositol 4,5-Bisphosphate Alters Synaptotagmin 1 Membrane Docking and Drives Opposing Bilayers Closer Together journal April 2011
Structural Determinants for Ca2+ and Phosphatidylinositol 4,5-Bisphosphate Binding by the C2A Domain of Rabphilin-3A journal December 2008
Secretion without Golgi journal January 2008
S100A13 Participates in the Release of Fibroblast Growth Factor 1 in Response to Heat Shock in Vitro journal June 2001
Role of copper transporters in copper homeostasis journal September 2008
The Calcium-Dependent and Calcium-Independent Membrane Binding of Synaptotagmin 1: Two Modes of C2B Binding journal March 2009
Unconventional Secretory Routes: Direct Protein Export Across the Plasma Membrane of Mammalian Cells journal August 2005
The Interaction of Human Tryptase-β with Small Molecule Inhibitors Provides New Insights into the Unusual Functional Instability and Quaternary Structure of the Protease journal March 2005
Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway journal September 2007
Copper Binding Affinity of S100A13, a Key Component of the FGF-1 Nonclassical Copper-Dependent Release Complex journal September 2006
Calorimetric studies of the binding of ferric ions to ovotransferrin and interactions between binding sites journal December 1991
Synaptotagmin 1 Modulates Lipid Acyl Chain Order in Lipid Bilayers by Demixing Phosphatidylserine journal July 2011
NMR characterization of copper and lipid interactions of the C2B domain of synaptotagmin I—relevance to the non-classical secretion of the human acidic fibroblast growth factor (hFGF-1) journal February 2010
Activation of the MAP Kinase Pathway by FGF-1 Correlates with Cell Proliferation Induction While Activation of the Src Pathway Correlates with Migration journal June 1998
Inactivation of human fibroblast growth factor-1 (FGF-1) activity by interaction with copper ions involves FGF-1 dimer formation induced by copper-catalyzed oxidation. journal June 1992
Synaptotagmin C2B Domain Regulates Ca 2+ -triggered Fusion in Vitro : CRITICAL RESIDUES REVEALED BY SCANNING ALANINE MUTAGENESIS journal September 2008
Functional Role of Two Interhelical Disulfide Bonds in Human Cox17 Protein from a Structural Perspective* journal September 2011
Three-Dimensional Structure of the Synaptotagmin 1 C2B-Domain journal December 2001
The annexin A2 system and vascular homeostasis journal March 2011
Synaptotagmin C2A Loop 2 Mediates Ca 2+ -dependent SNARE Interactions Essential for Ca 2+ -triggered Vesicle Exocytosis journal December 2007