Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

Gehrig, Jeanette; Venkatesh, Siddarth; Chang, Hao-Wei; Hibberd, Matthew C.; Kung, Vanderlene; Cheng, Jiye; Chen, Robert; Subramanian, Sathish; Cowardin, Carrie; Meier, Martin; O'Donnell, David; Talcott, Michael; Spears, Larry; Semenkovich, Clay; Henrissat, Bernard; Giannone, Richard J.; Hettich, Robert {Bob} L.; Ilkayeva, Olga; Muehlbauer, Michael; Newgard, Christopher; Sawyer, Christopher; Head, Richard; Rodionov, Dmitry A.; Arzamasov, Aleksandr; Leyn, Semen; Osterman, Andrei L.; Hossain, Md Iqbal; Islam, Munirul; Choudhury, Nuzhat; Sarker, Shafiqul; Huq, Sayeeda; Mahmud, Imteaz; Mostafa, Ishita; Mahfuz, Mustafa; Barratt, Michael J.; Ahmed, Tahmeed; Gordon, Jeffrey I.

doi:10.1126/science.aau4732

Title: Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

Journal Article · Fri Jul 12 00:00:00 EDT 2019 · Science

DOI:https://doi.org/10.1126/science.aau4732· OSTI ID:1546507

Gehrig, Jeanette ^[1]; Venkatesh, Siddarth ^[1]; Chang, Hao-Wei ^[1]; Hibberd, Matthew C. ^[1]; Kung, Vanderlene ^[1]; Cheng, Jiye ^[1]; Chen, Robert ^[1]; Subramanian, Sathish ^[1]; Cowardin, Carrie ^[1]; Meier, Martin ^[1]; O'Donnell, David ^[1]; Talcott, Michael ^[1]; Spears, Larry ^[1]; Semenkovich, Clay ^[1]; Henrissat, Bernard ^[2];

^[3];

^[3]; Ilkayeva, Olga ^[4]; Muehlbauer, Michael ^[4]; Newgard, Christopher ^[4] more »

Washington Univ., St. Louis, MO (United States)
Aix-Marseille Univ., and CNRS/IN2P3, Marseille (France); King Abdulaziz Univ., Jeddah (Saudi Arabia)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Duke Univ., Durham, NC (United States)
Sanford Burnham Prebys Medical Discovery Inst., La Jolla, CA (United States); Russian Academy of Sciences (RAS), Moscow (Russian Federation)
Sanford Burnham Prebys Medical Discovery Inst., La Jolla, CA (United States)
International Centre for Diarrhoeal Disease Research (Bangladesh)

To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1546507

Journal Information:: Science, Vol. 365, Issue 6449; ISSN 0036-8075

Publisher:: AAASCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 193 works

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