In Situ Measurements of Polymer Micellization Kinetics with Millisecond Temporal Resolution

Kalkowski, Joseph; Liu, Chang; Leon-Plata, Paola; Szymusiak, Magdalena; Zhang, Pin; Irving, Thomas; Shang, Weifeng; Bilsel, Osman; Liu, Ying

doi:10.1021/acs.macromol.8b02257

Title: In Situ Measurements of Polymer Micellization Kinetics with Millisecond Temporal Resolution

Journal Article · Mon Apr 15 00:00:00 EDT 2019 · Macromolecules

DOI:https://doi.org/10.1021/acs.macromol.8b02257· OSTI ID:1545859

^[1];

^[1]; Leon-Plata, Paola ^[2]; Szymusiak, Magdalena ^[1]; Zhang, Pin ^[1]; Irving, Thomas ^[3]; Shang, Weifeng ^[3]; Bilsel, Osman ^[4]; Liu, Ying ^[1]

Univ. of Illinois, Chicago, IL (United States)
Univ. of Illinois, Chicago, IL (United States)s
Illinois Inst. of Technology, Chicago, IL (United States)
Univ. of Massachusetts Medical School, Worchester, MA (United States)

Utilizing synchrotron small-angle X-ray scattering (SAXS) integrated with a microfluidic device, micellization kinetics of a diblock co-polymer, poly(ethylene glycol)-b-poly(caprolactone), was measured in situ with millisecond temporal and micrometer spatial resolution. Here, the evolutionary regimes of polymer micellization, nucleation, fusion, and insertion were directly observed. The five-inlet microfluidic device provided steady continuous mixing of the polymer solution and the antisolvent. The solvent replacement was mainly dominated by lateral diffusion across the hydrodynamically focused central layer, whose thickness could be precisely designed and manipulated from the mass balance of the partitioning streams. Knowing the micellization kinetics of the polymers is essential for the design and optimization of self-assembled polymeric nanostructures. The technique of integrating SAXS with microfluidic devices can be translatable to other systems for a breadth of applications.

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: National Science Foundation (NSF); USDOE Office of Science (SC); National Institute of General Medical Sciences (NIGMS); National Institutes of Health (NIH)

Grant/Contract Number:: 1350731; 1353942; AC02-06CH11357; 9 P41 GM103622; 1S10OD018090-01

OSTI ID:: 1545859

Journal Information:: Macromolecules, Vol. 52, Issue 9; ISSN 0024-9297

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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Cited by: 5 works

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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