Opening new paths for biological applications of ion mobility - Mass spectrometry using structures for lossless ion manipulations
Journal Article
·
· Trends in Analytical Chemistry. TrAC
- BATTELLE (PACIFIC NW LAB)
Ion mobility separations coupled to mass spectrometry (IM-MS) have received much attention for their ability to provide complementary structural information to solution-phase-based separations, as well as to aid in the identification of unknown compounds. While IM-MS is an increasingly powerful analytical technique, significant bottlenecks related to the resolution and sensitivity of measurements have kept it from becoming broadly applied for biological analyses. Structures for Lossless Ion Manipulations (SLIM)-based IM separations have successfully overcome these aforementioned bottlenecks, addressing issues associated with resolution and sensitivity in the omics, and potentially opening the door to broader application.
- Research Organization:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 1544781
- Report Number(s):
- PNNL-SA-140349
- Journal Information:
- Trends in Analytical Chemistry. TrAC, Journal Name: Trends in Analytical Chemistry. TrAC Vol. 116
- Country of Publication:
- United States
- Language:
- English
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