A methodology for performing global uncertainty and sensitivity analysis in systems biology
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September 2008 |
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
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August 2006 |
Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis
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July 2010 |
Differences in Reactivation of Tuberculosis Induced from Anti-TNF Treatments Are Based on Bioavailability in Granulomatous Tissue
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January 2007 |
CD4+ T cells with an activated and exhausted phenotype distinguish immunodeficiency during aviremic HIV-2 infection
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January 2016 |
Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques
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May 2008 |
Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment
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April 2003 |
Systems biology approaches for understanding cellular mechanisms of immunity in lymph nodes during infection
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October 2011 |
Multiscale Computational Modeling Reveals a Critical Role for TNF-α Receptor 1 Dynamics in Tuberculosis Granuloma Formation
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February 2011 |
High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival
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July 2016 |
A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment
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February 2015 |
TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection
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March 2016 |
T-cell exhaustion due to persistent antigen: Quantity not quality?: HIGHLIGHTS
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September 2012 |
Synergy between Individual TNF-Dependent Functions Determines Granuloma Performance for Controlling Mycobacterium tuberculosis Infection
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March 2009 |
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
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November 2008 |
Understanding Latent Tuberculosis: A Moving Target
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June 2010 |
Who puts the tubercle in tuberculosis?
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December 2006 |
From “truly naïve” to “exhausted senescent” T cells: When markers predict functionality: From “Truly Naïve” to “Exhausted Senescent” T Cells
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September 2013 |
Differential Risk of Tuberculosis Reactivation among Anti-TNF Therapies Is Due to Drug Binding Kinetics and Permeability
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February 2012 |
Early Events in Mycobacterium tuberculosis Infection in Cynomolgus Macaques
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June 2006 |
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
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August 2006 |
LAG-3, a novel lymphocyte activation gene closely related to CD4
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May 1990 |
Rhesus Macaques Are More Susceptible to Progressive Tuberculosis than Cynomolgus Macaques: a Quantitative Comparison
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September 2017 |
Characterization of Hepatitis B Virus (HBV)-Specific T-Cell Dysfunction in Chronic HBV Infection
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February 2007 |
PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion
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September 2006 |
Multi-Scale Modeling Predicts a Balance of Tumor Necrosis Factor-α and Interleukin-10 Controls the Granuloma Environment during Mycobacterium tuberculosis Infection
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July 2013 |
Functional Capacity of Mycobacterium tuberculosis -Specific T Cell Responses in Humans Is Associated with Mycobacterial Load
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July 2011 |
LAG3 Expression in Active Mycobacterium tuberculosis Infections
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March 2015 |
Inhibiting the Programmed Death 1 Pathway Rescues Mycobacterium tuberculosis–Specific Interferon γ–Producing T Cells From Apoptosis in Patients With Pulmonary Tuberculosis
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May 2013 |
Enhancing SIV-specific immunity in vivo by PD-1 blockade
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December 2008 |
Defective positioning in granulomas but not lung-homing limits CD4 T-cell interactions with Mycobacterium tuberculosis-infected macrophages in rhesus macaques
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July 2017 |
LAG-3 Regulates Plasmacytoid Dendritic Cell Homeostasis
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February 2009 |
Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model
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December 2017 |
NF-κB Signaling Dynamics Play a Key Role in Infection Control in Tuberculosis
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January 2012 |
Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function
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December 1998 |
In Vivo Blockade of the Programmed Cell Death-1 Pathway Using Soluble Recombinant PD-1-Fc Enhances CD4 + and CD8 + T Cell Responses but Has Limited Clinical Benefit
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November 2013 |
CD8 + T Cell Exhaustion, Suppressed Gamma Interferon Production, and Delayed Memory Response Induced by Chronic Brucella melitensis Infection
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September 2015 |
The Granuloma in Tuberculosis: Dynamics of a Host–Pathogen Collusion
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January 2013 |
Macrophages and control of granulomatous inflammation in tuberculosis
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March 2011 |
Programmed Death 1 Expression on HIV-Specific CD4 + T Cells Is Driven by Viral Replication and Associated with T Cell Dysfunction
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July 2007 |
T Cells from Programmed Death-1 Deficient Mice Respond Poorly to Mycobacterium tuberculosis Infection
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May 2011 |
The blockade of immune checkpoints in cancer immunotherapy
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March 2012 |
CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease
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May 2016 |
Programmed Death (PD)-1:PD-Ligand 1/PD-Ligand 2 Pathway Inhibits T Cell Effector Functions during Human Tuberculosis
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June 2008 |
T-cell exhaustion: characteristics, causes and conversion: T-cell exhaustion
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February 2010 |
Integrated Transcriptomics Establish Macrophage Polarization Signatures and have Potential Applications for Clinical Health and Disease
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August 2015 |
Identifying control mechanisms of granuloma formation during M. tuberculosis infection using an agent-based model
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December 2004 |
The timing of TNF and IFN-γ signaling affects macrophage activation strategies during Mycobacterium tuberculosis infection
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May 2008 |
A comparison of random vs. chemotaxis-driven contacts of T cells with dendritic cells during repertoire scanning
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February 2008 |
Identification of Key Processes that Control Tumor Necrosis Factor Availability in a Tuberculosis Granuloma
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May 2010 |
T cell exhaustion
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May 2011 |
Restoring function in exhausted CD8 T cells during chronic viral infection
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December 2005 |
Anti-TIM3 Antibody Promotes T Cell IFN- -Mediated Antitumor Immunity and Suppresses Established Tumors
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March 2011 |
PD-1/PD-L pathway inhibits M.tb-specific CD4+ T-cell functions and phagocytosis of macrophages in active tuberculosis
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December 2016 |
Re-Evaluation of PD-1 Expression by T Cells as a Marker for Immune Exhaustion during SIV Infection
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March 2013 |
Variability in Tuberculosis Granuloma T Cell Responses Exists, but a Balance of Pro- and Anti-inflammatory Cytokines Is Associated with Sterilization
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January 2015 |
Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms
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June 2013 |
Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection
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February 2014 |
Experimental Mycobacterium tuberculosis Infection of Cynomolgus Macaques Closely Resembles the Various Manifestations of Human M. tuberculosis Infection
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September 2003 |
CD4 T Cells Promote Rather than Control Tuberculosis in the Absence of PD-1–Mediated Inhibition
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December 2010 |
Chronic Antigen Stimulation Alone Is Sufficient to Drive CD8 + T Cell Exhaustion
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May 2009 |
Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model
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July 2009 |
Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells
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July 2005 |
Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression
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December 2006 |
Distinct functions of antigen-specific CD4 T cells during murine Mycobacterium tuberculosis infection
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October 2010 |
Computational Modeling Predicts IL-10 Control of Lesion Sterilization by Balancing Early Host Immunity–Mediated Antimicrobial Responses with Caseation during Mycobacterium tuberculosis Infection
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December 2014 |
T-cell exhaustion in the tumor microenvironment
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June 2015 |
Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell–dendritic cell interaction
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April 2006 |
Elevated expression of miR-146a correlates with high levels of immune cell exhaustion markers and suppresses cellular immune function in chronic HIV-1-infected patients
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December 2019 |
Origin of tuberculosis in the Paleolithic predicts unprecedented population growth and female resistance
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January 2020 |
Differences in reactivation of tuberculosis induced from anti-TNF treatments are based on bioavailability in granulomatous tissue
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January 2005 |