Photophysical and Photobiological Properties of Dinuclear Iridium(III) Bis-tridentate Complexes

Liu, Bingqing; Monro, Susan; Lystrom, Levi; Cameron, Colin G.; Colón, Katsuya; Yin, Huimin; Kilina, Svetlana; McFarland, Sherri A.; Sun, Wenfang

doi:10.1021/acs.inorgchem.8b00789

Photophysical and Photobiological Properties of Dinuclear Iridium(III) Bis-tridentate Complexes

Journal Article · Mon Apr 09 00:00:00 EDT 2018 · Inorganic Chemistry

DOI:https://doi.org/10.1021/acs.inorgchem.8b00789· OSTI ID:1543620

Liu, Bingqing ^[1]; Monro, Susan ^[2]; Lystrom, Levi ^[1]; Cameron, Colin G. ^[3]; Colón, Katsuya ^[3]; Yin, Huimin ^[2]; ^[1]; ^[4]; ^[1]

North Dakota State Univ., Fargo, ND (United States)
Acadia Univ., Wolfville, NS (Canada)
Univ. of North Carolina, Greensboro, NC (United States)
Acadia Univ., Wolfville, NS (Canada); Univ. of North Carolina, Greensboro, NC (United States)

A series of cationic dinuclear iridium(III) complexes (Ir1–Ir5) bearing terpyridine-capped fluorenyl bridging ligands and different polypyridyl or cyclometalating terminal tridentate ligands were synthesized, characterized, and evaluated for their photophysical and photobiological activities. The influence of the bridging and terminal ligands on the photophysical properties of the complexes was investigated by UV–vis absorption, emission, and transient absorption spectroscopy and simulated by TDDFT calculations. All of the complexes displayed strong bridging-ligand localized visible ¹π,π* absorption and red- or near-infrared phosphorescence as well as broad triplet excited-state absorption across both visible and NIR wavelengths. These triplet states were assigned as predominantly ³π,π* for Ir1 (τ = 3.1 μs) and Ir4 (τ = 48 μs) and ³CT (charge transfer) for Ir2, Ir3, and Ir5 (τ = 1.7–2.7 μs). Complexes Ir1–Ir5 acted as in vitro photodynamic therapy (PDT) agents toward human SK-MEL-28 melanoma cells when activated with visible light, with submicromolar photocytotoxicity and phototherapeutic indices ranging from 20 to almost 300. The in vitro PDT effects with visible light did not correlate with singlet oxygen (1O2) quantum yields or DNA photocleaving capacity probed under cell-free conditions. All of the Ir(III) complexes phosphoresced brightly when associated with compromised cells (with or without light treatment) and exhibited photoactivated cellular uptake, highlighting the theranostic potential of this new class of Ir(III) complex photosensitizers.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC); Univ. of California, Oakland, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1543620

Journal Information:: Inorganic Chemistry, Journal Name: Inorganic Chemistry Journal Issue: 16 Vol. 57; ISSN 0020-1669

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Multinuclear Ru( ii ) and Ir( iii ) decorated tetraphenylporphyrins as efficient PDT agents Cabrera-González, Justo; Soriano, Jorge; Conway-Kenny, Robert Biomaterials Science, Vol. 7, Issue 8 https://doi.org/10.1039/c9bm00192a	journal	January 2019
Heteroleptic cationic iridium( iii ) complexes bearing phenanthroline derivatives with extended π-conjugation as potential broadband reverse saturable absorbers Wang, Li; Cui, Peng; Lystrom, Levi New Journal of Chemistry, Vol. 44, Issue 2 https://doi.org/10.1039/c9nj03877a	journal	January 2020
Solvent-induced aggregation based on a heteroleptic Ir( iii ) complex via hydrogen bonds Song, Zhongming; Wang, Jia; Liu, Rui Journal of Materials Chemistry C, Vol. 7, Issue 23 https://doi.org/10.1039/c9tc01299k	journal	January 2019

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