skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs)

Journal Article · · Biomacromolecules

Not provided.

Research Organization:
Stanford Univ., CA (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
DOE Contract Number:
SC0018168
OSTI ID:
1538971
Journal Information:
Biomacromolecules, Vol. 19, Issue 7; ISSN 1525-7797
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English

References (71)

Development of Poly(β-amino ester)-Based Biodegradable Nanoparticles for Nonviral Delivery of Minicircle DNA journal July 2013
Viral vectors: from virology to transgene expression: Viral vectors: from virology to transgene expression journal April 2009
Advanced transfection with Lipofectamine 2000 reagent: primary neurons, siRNA, and high-throughput applications journal June 2004
Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity journal March 2011
Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype journal March 2014
The Fate of Plasmid DNA After Intravenous Injection in Mice: Involvement of Scavenger Receptors in Its Hepatic Uptake journal January 1995
Cytotoxicity Associated with Artemis Overexpression After Lentiviral Vector-Mediated Gene Transfer journal July 2010
High-Resolution Genome-Wide Mapping of Transposon Integration in Mammals journal March 2005
Evaluation of a Cationic Poly(β-hydroxyalkanoate) as a Plasmid DNA Delivery System journal May 2009
Control of astrocyte Ca2+ oscillations and waves by oscillating translocation and activation of protein kinase C journal July 2001
Investigating siRNA delivery to chronic myeloid leukemia K562 cells with lipophilic polymers for therapeutic BCR-ABL down-regulation journal December 2013
Function Oriented Synthesis: The Design, Synthesis, PKC Binding and Translocation Activity of a New Bryostatin Analog journal January 2004
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates journal May 2009
Synthetic Nucleic Acid Delivery Systems: Present and Perspectives journal February 2015
Palmitic acid substitution on cationic polymers for effective delivery of plasmid DNA to bone marrow stromal cells journal January 2007
Evaluation of Cationic Assemblies Constructed with Amino Acid Based Lipids for Plasmid DNA Delivery journal April 2008
Degradable Poly(β-amino esters):  Synthesis, Characterization, and Self-Assembly with Plasmid DNA journal November 2000
Evaluation of polyplexes as gene transfer agents journal June 2001
Investigating the Effects of Block versus Statistical Glycopolycations Containing Primary and Tertiary Amines for Plasmid DNA Delivery journal June 2014
Organocatalytic Ring-Opening Polymerization journal December 2007
In Vivo Delivery Systems for Therapeutic Genome Editing journal April 2016
A Combinatorial Polymer Library Approach Yields Insight into Nonviral Gene Delivery journal June 2008
How cationic lipids transfer nucleic acids into cells and across cellular membranes: Recent advances journal February 2013
Biodegradable polymers as non-viral carriers for plasmid DNA delivery journal March 2008
Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side journal April 2017
De Novo Synthesis and Cellular Uptake of Organic Nanocapsules with Tunable Surface Chemistry journal June 2011
Thiourea-Based Bifunctional Organocatalysis:  Supramolecular Recognition for Living Polymerization journal October 2005
Molecular Reconstruction of Sleeping Beauty, a Tc1-like Transposon from Fish, and Its Transposition in Human Cells journal November 1997
Simplified Analogs of Bryostatin with Anticancer Activity Display Greater Potency for Translocation of PKCδ-GFP journal September 2004
Physical methods for gene transfer: Improving the kinetics of gene delivery into cells journal April 2005
Gene Transfer via Reversible Plasmid Condensation with Cysteine-Flanked, Internally Spaced Arginine-Rich Peptides journal September 2003
Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system journal January 2006
Utilizing Combinatorial Chemistry and Rational Design: Peptidic Tweezers with Nanomolar Affinity to DNA Can Be Transformed into Efficient Vectors for Gene Delivery by Addition of a Lipophilic Tail journal November 2013
The cytotoxicity of anti-CD22 immunotoxin is enhanced by bryostatin 1 in B-cell lymphomas through CD22 upregulation and PKC- II depletion journal December 2011
Multi-Emissive Difluoroboron Dibenzoylmethane Polylactide Exhibiting Intense Fluorescence and Oxygen-Sensitive Room-Temperature Phosphorescence journal July 2007
Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals journal January 2017
Hydrazone-modulated peptides for efficient gene transfection journal January 2017
Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer journal April 1999
Synthesis of Water-Soluble Imidazolium Polyesters as Potential Nonviral Gene Delivery Vehicles journal December 2016
Exploration, Optimization, and Application of Supramolecular Thiourea−Amine Catalysts for the Synthesis of Lactide (Co)polymers journal November 2006
Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown journal July 2010
Structural advantage of dendritic poly(l-lysine) for gene delivery into cells journal January 2007
Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis journal January 2005
Sleeping Beauty Transposon‐Mediated Gene Therapy for Prolonged Expression book January 2005
Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV journal October 2017
Lipid-mediated delivery of RNA is more efficient than delivery of DNA in non-dividing cells journal April 2010
Lipophilic and cationic triphenylphosphonium grafted linear polyethylenimine polymers for efficient gene delivery to mammalian cells journal January 2012
In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa journal March 2016
Tagging alcohols with cyclic carbonate: a versatile equivalent of (meth)acrylate for ring-opening polymerization journal January 2008
Complex Coacervation-Integrated Hybrid Nanoparticles Increasing Plasmid DNA Delivery Efficiency in Vivo journal November 2016
Challenges in DNA Delivery and Recent Advances in Multifunctional Polymeric DNA Delivery Systems journal July 2017
Lipophilic Polycation Vehicles Display High Plasmid DNA Delivery to Multiple Cell Types journal July 2017
Gene Therapy: Some History, Applications, Problems, and Prospects journal January 2008
Nonviral Vectors for Gene Delivery journal February 2009
New Sequence-Defined Polyaminoamides with Tailored Endosomolytic Properties for Plasmid DNA Delivery journal May 2012
Organocatalytic Ring-Opening Polymerization of Morpholinones: New Strategies to Functionalized Polyesters journal June 2014
Stearylated Arginine-Rich Peptides:  A New Class of Transfection Systems journal October 2001
A Novel Assay for Quantifying the Number of Plasmids Encapsulated by Polymer Nanoparticles journal December 2011
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays journal December 1983
Optimal Hydrophobicity in Ring-Opening Metathesis Polymerization-Based Protein Mimics Required for siRNA Internalization journal May 2016
Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells journal July 2012
Putative Role of Chloroquine in Gene Transfer into a Human Hepatoma Cell Line by DNA/Lactosylated Polylysine Complexes journal May 1996
The Use of Inhibitors to Study Endocytic Pathways of Gene Carriers: Optimization and Pitfalls journal March 2010
Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery journal September 2015
Formulation and Delivery of siRNA by Oleic Acid and Stearic Acid Modified Polyethylenimine journal December 2008
Longitudinal, Noninvasive Imaging of T-Cell Effector Function and Proliferation in Living Subjects journal December 2010
Optimized production and concentration of lentiviral vectors containing large inserts journal January 2007
Biodegradable cationic polyester as an efficient carrier for gene delivery to neonatal cardiomyocytes journal January 2006
The design of guanidinium-rich transporters and their internalization mechanisms journal March 2008
Temperature dependence of endocytosis mediated by the asialoglycoprotein receptor in isolated rat hepatocytes. Evidence for two potentially rate-limiting steps. journal March 1981
Entry of the toxic proteins abrin, modeccin, ricin, and diphtheria toxin into cells. II. Effect of pH, metabolic inhibitors, and ionophores and evidence for toxin penetration from endocytotic vesicles. journal July 1982

Cited By (8)

Development of Ester Free Type Poly(trimethylene carbonate) Derivatives with Pendant Fluoroaromatic Groups journal April 2019
Bis‐Thioether‐Containing Lipid Chains in Cationic Amphiphiles: Physicochemical Properties and Applications in Gene Delivery journal August 2019
Synthesis of levulinic acid based poly(amine- co -ester)s journal January 2019
Recent advances in polymeric materials for the delivery of RNA therapeutics journal September 2019
Delivery of Inorganic Polyphosphate into Cells Using Amphipathic Oligocarbonate Transporters journal September 2018
Reversible RNA acylation for control of CRISPR–Cas9 gene editing journal January 2020
mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice journal September 2018
Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters journal June 2018

Similar Records

Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs)
Journal Article · Fri May 04 00:00:00 EDT 2018 · Biomacromolecules · OSTI ID:1538971

Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters
Journal Article · Mon Jun 11 00:00:00 EDT 2018 · Proceedings of the National Academy of Sciences of the United States of America · OSTI ID:1538971

Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals
Journal Article · Mon Jan 09 00:00:00 EST 2017 · Proceedings of the National Academy of Sciences of the United States of America · OSTI ID:1538971