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Title: Altered expression of a metformin-mediated radiation response in SA-NH and FSa tumor cells treated under in vitro and in vivo growth conditions

Journal Article · · International Journal of Radiation Biology
 [1];  [1];  [1];  [2];  [1]
  1. Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA,
  2. Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
+ Show Author Affiliations

Not provided.

Research Organization:
Northwestern Univ., Evanston, IL (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
DOE Contract Number:
SC0001271
OSTI ID:
1535395
Journal Information:
International Journal of Radiation Biology, Vol. 93, Issue 7; ISSN 0955-3002
Publisher:
Taylor and Francis
Country of Publication:
United States
Language:
English

References (34)

Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage journal January 2012
Metformin directly acts on mitochondria to alter cellular bioenergetics journal January 2014
Prevention of Mutagenesis: New Potential Mechanisms of Metformin Action in Neoplastic Cells journal April 2012
Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells journal April 2014
Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth journal July 2007
Metformin decreases growth of pancreatic cancer cells by decreasing reactive oxygen species: Role of NOX4 journal September 2015
Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells journal May 2016
Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer journal May 2013
Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone journal March 2011
Differential programming of p53-deficient embryonic cells during rotenone block journal November 2011
Radical-induced oxidation of metformin journal December 2004
Metformin: A Novel Biological Modifier of Tumor Response to Radiation Therapy journal October 2015
Extension of Multiple Range Tests to Group Means with Unequal Numbers of Replications journal September 1956
p53 Regulates Mitochondrial Respiration journal June 2006
Metformin Exhibits Radiation Countermeasures Efficacy When Used Alone or in Combination with Sulfhydryl Containing Drugs journal May 2014
Very low doses of ionizing radiation and redox associated modifiers affect survivin-associated changes in radiation sensitivity journal October 2016
Contributions of AMPK and p53 dependent signaling to radiation response in the presence of metformin journal September 2013
Delayed Radioprotection by NFκB-Mediated Induction of Sod2 (MnSOD) in SA-NH Tumor Cells after Exposure to Clinically Used Thiol-Containing Drugs journal November 2004
Oxidative stress specifically downregulates survivin to promote breast tumour formation journal February 2013
Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect journal May 2015
The antioxidant function of the p53 tumor suppressor journal November 2005
Lack of correlation between mitotic arrest or apoptosis and antitumor effect of docetaxel journal February 1999
Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth journal October 2015
Metformin use and improved response to therapy in rectal cancer journal January 2013
Oxidative phosphorylation in cancer cells journal June 2011
Molecular mechanism of emodin action: Transition from laxative ingredient to an antitumor agent journal January 2007
Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK journal April 2013
Metformin: A Novel but Controversial Drug in Cancer Prevention and Treatment journal October 2015
Mitochondrial formation of reactive oxygen species journal October 2003
Targeting mitochondria metabolism for cancer therapy journal December 2014
Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response journal October 2013
Metformin Sensitizes Prostate Cancer Cells to Radiation Through EGFR/p-DNA-PKCS In Vitro and In Vivo journal May 2014
Involvement of metformin and AMPK in the radioresponse and prognosis of luminal versus basal-like breast cancer treated with radiotherapy journal November 2014
Mitochondrial impairment in p53-deficient human cancer cells journal May 2003

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