Tuning phase and aging of DNA hydrogels through molecular design

Nguyen, Dan T.; Saleh, Omar A.

doi:10.1039/c7sm00557a

Title: Tuning phase and aging of DNA hydrogels through molecular design

Journal Article · Sun Jan 01 00:00:00 EST 2017 · Soft Matter

DOI:https://doi.org/10.1039/c7sm00557a· OSTI ID:1535247

^[1];

^[2]

Biomolecular Science and Engineering Program; University of California; Santa Barbara; USA
Materials Department and Biomolecular Science and Engineering Program; University of California; Santa Barbara; USA

Using self-assembling, multi-valent DNA nanostars, we show that DNA hydrogel phase and structure can be controlled by tuning hydrogel aging kinetics through the rational design of gel-forming elements and solvent conditions.

Cite

Export

Save

Research Organization:: Univ. of California, Santa Barbara, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

DOE Contract Number:: SC0014427

OSTI ID:: 1535247

Journal Information:: Soft Matter, Vol. 13, Issue 32; ISSN 1744-683X

Publisher:: Royal Society of Chemistry

Country of Publication:: United States

Language:: English

References (22)

Enzyme-catalysed assembly of DNA hydrogel Um, Soong Ho; Lee, Jong Bum; Park, Nokyoung Nature Materials, Vol. 5, Issue 10 https://doi.org/10.1038/nmat1741	journal	September 2006
Self-assembly of DNA Nanohydrogels with Controllable Size and Stimuli-Responsive Property for Targeted Gene Regulation Therapy Li, Juan; Zheng, Cheng; Cansiz, Sena Journal of the American Chemical Society, Vol. 137, Issue 4 https://doi.org/10.1021/ja512293f	journal	January 2015
DNA delivery from polymer matrices for tissue engineering Shea, Lonnie D.; Smiley, Elizabeth; Bonadio, Jeffrey Nature Biotechnology, Vol. 17, Issue 6 https://doi.org/10.1038/9853	journal	June 1999
An Aptamer Cross-Linked Hydrogel as a Colorimetric Platform for Visual Detection Zhu, Zhi; Wu, Cuichen; Liu, Haipeng Angewandte Chemie, Vol. 122, Issue 6 https://doi.org/10.1002/ange.200905570	journal	January 2010
Aptamer based reversible DNA induced hydrogel system for molecular recognition and separation He, Xiaojin; Wei, Bryan; Mi, Yongli Chemical Communications, Vol. 46, Issue 34 https://doi.org/10.1039/c0cc01392g	journal	January 2010
Hydrogel formation via hybridization of oligonucleotides derivatized in water-soluble vinyl polymers Nagahara, Shunji; Matsuda, Takehisa Polymer Gels and Networks, Vol. 4, Issue 2 https://doi.org/10.1016/0966-7822(96)00001-9	journal	January 1996
A pH-Triggered, Fast-Responding DNA Hydrogel Cheng, Enjun; Xing, Yongzheng; Chen, Ping Angewandte Chemie International Edition, Vol. 48, Issue 41 https://doi.org/10.1002/anie.200902538	journal	September 2009
Photoresponsive DNA-Cross-Linked Hydrogels for Controllable Release and Cancer Therapy Kang, Huaizhi; Liu, Haipeng; Zhang, Xiaoling Langmuir, Vol. 27, Issue 1 https://doi.org/10.1021/la1037553	journal	January 2011
Mechanical Properties of a Reversible, DNA-Crosslinked Polyacrylamide Hydrogel Lin, David C.; Yurke, Bernard; Langrana, Noshir A. Journal of Biomechanical Engineering, Vol. 126, Issue 1 https://doi.org/10.1115/1.1645529	journal	February 2004
Self-Assembled DNA Hydrogels with Designable Thermal and Enzymatic Responsiveness Xing, Yongzheng; Cheng, Enjun; Yang, Yang Advanced Materials, Vol. 23, Issue 9 https://doi.org/10.1002/adma.201003343	journal	December 2010
Bioresponsive DNA Hydrogels: Beyond the Conventional Stimuli Responsiveness Wang, Dong; Hu, Yue; Liu, Peifeng Accounts of Chemical Research, Vol. 50, Issue 4 https://doi.org/10.1021/acs.accounts.6b00581	journal	February 2017
Phase behavior and critical activated dynamics of limited-valence DNA nanostars Biffi, S.; Cerbino, R.; Bomboi, F. Proceedings of the National Academy of Sciences, Vol. 110, Issue 39 https://doi.org/10.1073/pnas.1304632110	journal	September 2013
RNA transcription modulates phase transition-driven nuclear body assembly Berry, Joel; Weber, Stephanie C.; Vaidya, Nilesh Proceedings of the National Academy of Sciences, Vol. 112, Issue 38 https://doi.org/10.1073/pnas.1509317112	journal	September 2015
RNA Controls PolyQ Protein Phase Transitions Zhang, Huaiying; Elbaum-Garfinkle, Shana; Langdon, Erin M. Molecular Cell, Vol. 60, Issue 2 https://doi.org/10.1016/j.molcel.2015.09.017	journal	October 2015
Structure of Particulate Whey Protein Gels: Effect of NaCl Concentration, pH, Heating Temperature, and Protein Composition Verheul, Marleen; Roefs, Sebastianus P. F. M. Journal of Agricultural and Food Chemistry, Vol. 46, Issue 12 https://doi.org/10.1021/jf981100f	journal	December 1998
DINAMelt web server for nucleic acid melting prediction Markham, N. R.; Zuker, M. Nucleic Acids Research, Vol. 33, Issue Web Server https://doi.org/10.1093/nar/gki591	journal	July 2005
A thin permeable-membrane device for single-molecule manipulation Park, Chang-Young; Jacobson, David R.; Nguyen, Dan T. Review of Scientific Instruments, Vol. 87, Issue 1 https://doi.org/10.1063/1.4939197	journal	January 2016
Swelling properties of cross-linked DNA gels Costa, Diana; Miguel, M. Graça; Lindman, Björn Advances in Colloid and Interface Science, Vol. 158, Issue 1-2 https://doi.org/10.1016/j.cis.2009.10.002	journal	July 2010
The stability and characteristics of a DNA Holliday junction switch Mount, A. R.; Mountford, C. P.; Evans, S. A. G. Biophysical Chemistry, Vol. 124, Issue 3 https://doi.org/10.1016/j.bpc.2006.03.020	journal	December 2006
Mechanical properties of DNA origami nanoassemblies are determined by Holliday junction mechanophores Shrestha, Prakash; Emura, Tomoko; Koirala, Deepak Nucleic Acids Research, Vol. 44, Issue 14 https://doi.org/10.1093/nar/gkw610	journal	July 2016
Globally optimal stitching of tiled 3D microscopic image acquisitions Preibisch, S.; Saalfeld, S.; Tomancak, P. Bioinformatics, Vol. 25, Issue 11 https://doi.org/10.1093/bioinformatics/btp184	journal	April 2009
Fiji: an open-source platform for biological-image analysis Schindelin, Johannes; Arganda-Carreras, Ignacio; Frise, Erwin Nature Methods, Vol. 9, Issue 7 https://doi.org/10.1038/nmeth.2019	journal	June 2012

Similar Records

Strain Distributions and Structural Changes in Motor Driven Gels (Final Report)

Technical Report · Mon Apr 29 00:00:00 EDT 2019 · OSTI ID:1535247

Saleh, Omar; Fygenson, Deborah; McMeeking, Robert

Regulating phase behavior of nanoparticle assemblies through engineering of DNA-mediated isotropic interactions

Journal Article · Mon Dec 18 00:00:00 EST 2023 · Proceedings of the National Academy of Sciences of the United States of America · OSTI ID:1535247

Mao, Runfang; Minevich, Brian; McKeen, Daniel; +4 more

Salt-dependent properties of a coacervate-like, self-assembled DNA liquid

Journal Article · Mon Jan 01 00:00:00 EST 2018 · Soft Matter · OSTI ID:1535247

Jeon, Byoung-jin; Nguyen, Dan T.; Abraham, Gabrielle R.; +3 more

Related Subjects

Chemistry
Materials Science
Physics
Polymer Science

Title: Tuning phase and aging of DNA hydrogels through molecular design

Citation Formats

References (22)

Similar Records

Related Subjects