Single-Molecule Chemistry with Surface- and Tip-Enhanced Raman Spectroscopy

Zrimsek, Alyssa B.; Chiang, Naihao; Mattei, Michael; Zaleski, Stephanie; McAnally, Michael O.; Chapman, Craig T.; Henry, Anne-Isabelle; Schatz, George C.; Van Duyne, Richard P.

doi:10.1021/acs.chemrev.6b00552

Single-Molecule Chemistry with Surface- and Tip-Enhanced Raman Spectroscopy

Journal Article · Wed Dec 07 23:00:00 EST 2016 · Chemical Reviews

DOI:https://doi.org/10.1021/acs.chemrev.6b00552· OSTI ID:1534472

Zrimsek, Alyssa B. ^[1]; Chiang, Naihao ^[2]; Mattei, Michael ^[2]; Zaleski, Stephanie ^[2]; ^[2]; ^[2]; Henry, Anne-Isabelle ^[2]; Schatz, George C. ^[2]; ^[2]

Northwestern Univ., Evanston, IL (United States); DOE/OSTI
Northwestern Univ., Evanston, IL (United States)

Single-molecule (SM) surface-enhanced Raman spectroscopy (SERS) and tip-enhanced Raman spectroscopy (TERS) have emerged as analytical techniques for characterizing molecular systems in nanoscale environments. SERS and TERS use plasmonically enhanced Raman scattering to characterize the chemical information on single molecules. Additionally, TERS can image single molecules with subnanometer spatial resolution. Here, we cover the development and history of SERS and TERS, including the concept of SERS hot spots and the plasmonic nanostructures necessary for SM detection, the past and current methodologies for verifying SMSERS, and investigations into understanding the signal heterogeneities observed with SMSERS. Moving on to TERS, we cover tip fabrication and the physical origins of the subnanometer spatial resolution. Then, we highlight recent advances of SMSERS and TERS in fields such as electrochemistry, catalysis, and SM electronics, which all benefit from the vibrational characterization of single molecules. SMSERS and TERS provide new insights on molecular behavior that would otherwise be obscured in an ensemble-averaged measurement.

View Accepted Manuscript (DOE)

Research Organization:: Northwestern Univ., Evanston, IL (United States)

Sponsoring Organization:: National Science Foundation (NSF); US Air Force Office of Scientific Research (AFOSR); USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0001785; SC0001785

OSTI ID:: 1534472

Journal Information:: Chemical Reviews, Journal Name: Chemical Reviews Journal Issue: 11 Vol. 117; ISSN 0009-2665

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Surface- and tip-enhanced Raman spectroscopy of DNA Hennemann, L. E.; Meixner, A. J.; Zhang, D. Spectroscopy, Vol. 24, Issue 1-2 https://doi.org/10.1155/2010/428026	journal	January 2010
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Surface-enhanced optical microscopy Wessel, John Journal of the Optical Society of America B, Vol. 2, Issue 9 https://doi.org/10.1364/JOSAB.2.001538	journal	January 1985
Localized enhancement of electric field in tip-enhanced Raman spectroscopy using radially and linearly polarized light Kazemi-Zanjani, Nastaran; Vedraine, Sylvain; Lagugné-Labarthet, François Optics Express, Vol. 21, Issue 21 https://doi.org/10.1364/OE.21.025271	journal	January 2013
Gold-coated AFM tips for tip-enhanced Raman spectroscopy: theoretical calculation and experimental demonstration Meng, Lingyan; Huang, Tengxiang; Wang, Xiang Optics Express, Vol. 23, Issue 11 https://doi.org/10.1364/OE.23.013804	journal	January 2015
Photon antibunching in the fluorescence of a single dye molecule embedded in a thin polymer film Treussart, François; Clouqueur, André; Grossman, Carl Optics Letters, Vol. 26, Issue 19 https://doi.org/10.1364/OL.26.001504	journal	January 2001
Enhancement of Raman Signals with Silver-Coated Tips Yeo, Boon-Siang; Zhang, Weihua; Vannier, Christophe Applied Spectroscopy, Vol. 60, Issue 10 https://doi.org/10.1366/000370206778664662	journal	October 2006
Plasmonic Materials for Surface-Enhanced Sensing and Spectroscopy Haes, Amanda J.; Haynes, Christy L.; McFarland, Adam D. MRS Bulletin, Vol. 30, Issue 5 https://doi.org/10.1557/mrs2005.100	journal	May 2005
Distinction of nucleobases – a tip-enhanced Raman approach Treffer, Regina; Lin, Xiumei; Bailo, Elena Beilstein Journal of Nanotechnology, Vol. 2 https://doi.org/10.3762/bjnano.2.66	journal	January 2011
Surface Enhanced Raman Spectroscopy: Towards Single Molecule Spectroscopy Pettinger, Bruno; Picardi, Gennaro; Schuster, Rolf Electrochemistry, Vol. 68, Issue 12 https://doi.org/10.5796/electrochemistry.68.942	journal	January 2000

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DERS substrate based on NERS-SERS interaction in integrated microfluidic detection Xiao, Cheng; Chen, Zhibin; Qin, Mengze Applied Optics, Vol. 57, Issue 12 https://doi.org/10.1364/ao.57.003172	journal	January 2018
Ultrafast Stimulated Emission Microscopy of Single Nanocrystals Piatkowski, Lukasz; Accanto, Nicolò; Calbris, Gaetan CLEO: QELS_Fundamental Science, Conference on Lasers and Electro-Optics https://doi.org/10.1364/cleo_qels.2020.fth1q.2	conference	January 2020
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