Mechanisms of Selective Antitumor Action of Cold Atmospheric Plasma-Derived Reactive Oxygen and Nitrogen Species

Bauer, Georg; Graves, David B.

doi:10.1002/ppap.201600089

Title: Mechanisms of Selective Antitumor Action of Cold Atmospheric Plasma-Derived Reactive Oxygen and Nitrogen Species

Journal Article · Fri Oct 14 00:00:00 EDT 2016 · Plasma Processes and Polymers

DOI:https://doi.org/10.1002/ppap.201600089· OSTI ID:1533213

Bauer, Georg ^[1]; Graves, David B. ^[2]

Univ. of Freiburg (Germany)
Univ. of California, Berkeley, CA (United States)

Transformed cells are subject to elimination through intercellular reactive oxygen/nitrogen species (RONS)-dependent apoptosis-inducing signaling. Tumor progression, therefore, requires expression of membrane-bound catalase. Recent research demonstrates that ¹O₂ can inactivate membrane-bound catalase, thus, inducing the generation of tumor cell-derived secondary ¹O₂ and RONS-dependent apoptosis selectively in tumor cells. Crucially, ¹O₂ signaling can result in self-perpetuating apoptotic signaling from cell-to-cell. It is known that CAP contains ¹O₂ and that certain CAP constituents can generate ¹O₂ in solution. The analysis of model experiments performed with defined RONS implies that CAP-derived ¹O₂ induces the mechanism through which CAP acts selectively against cancer cells in vitro and tumors in vivo. Finally, this hypothesis needs to be tested experimentally in order to establish its validity.

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Research Organization:: Northern Illinois Univ., DeKalb, IL (United States); Univ. of California, Oakland, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC); National Science Foundation (NSF); EuroTransBio; COST Action

Grant/Contract Number:: SC0001934; SC0012500; 1415022; ETB1 0315012B; CM0603

OSTI ID:: 1533213

Journal Information:: Plasma Processes and Polymers, Vol. 13, Issue 12; ISSN 1612-8850

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 93 works

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Cold Atmospheric Plasma and Plasma-Activated Medium Trigger RONS-Based Tumor Cell Apoptosis Bauer, Georg; Sersenová, Dominika; Graves, David B. Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-50291-0	journal	October 2019
Plasma-activated medium triggers cell death and the presentation of immune activating danger signals in melanoma and pancreatic cancer cells Azzariti, Amalia; Iacobazzi, Rosa Maria; Di Fonte, Roberta Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-40637-z	journal	March 2019
Dynamics of Singlet Oxygen-Triggered, RONS-Based Apoptosis Induction after Treatment of Tumor Cells with Cold Atmospheric Plasma or Plasma-Activated Medium Bauer, Georg; Sersenová, Dominika; Graves, David B. Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-50329-3	journal	September 2019
Molecular admixtures and impurities in atmospheric pressure plasma jets Lietz, Amanda M.; Kushner, Mark J. Journal of Applied Physics, Vol. 124, Issue 15 https://doi.org/10.1063/1.5049430	journal	October 2018
The 2017 Plasma Roadmap: Low temperature plasma science and technology Adamovich, I.; Baalrud, S. D.; Bogaerts, A. Journal of Physics D: Applied Physics, Vol. 50, Issue 32 https://doi.org/10.1088/1361-6463/aa76f5	journal	July 2017
Chemical and antibacterial effects of plasma activated water: correlation with gaseous and aqueous reactive oxygen and nitrogen species, plasma sources and air flow conditions Machala, Z.; Tarabová, B.; Sersenová, D. Journal of Physics D: Applied Physics, Vol. 52, Issue 3 https://doi.org/10.1088/1361-6463/aae807	journal	November 2018
Characterisation of a multijet plasma device by means of mass spectrometric detection and iCCD imaging Stancampiano, A.; Selaković, N.; Gherardi, M. Journal of Physics D: Applied Physics, Vol. 51, Issue 48 https://doi.org/10.1088/1361-6463/aae2f2	journal	October 2018
Molecular mechanisms of non-thermal plasma-induced effects in cancer cells Tanaka, Hiromasa; Mizuno, Masaaki; Ishikawa, Kenji Biological Chemistry, Vol. 400, Issue 1 https://doi.org/10.1515/hsz-2018-0199	journal	December 2018
Cold plasma-based control of the activation of pancreatic adenocarcinoma cells Yan, Dayun; Lin, Li; Xu, Wenjun Journal of Physics D: Applied Physics, Vol. 52, Issue 44 https://doi.org/10.1088/1361-6463/ab36d4	journal	August 2019
Cold Physical Plasma Modulates p53 and Mitogen-Activated Protein Kinase Signaling in Keratinocytes Schmidt, Anke; Bekeschus, Sander; Jarick, Katja Oxidative Medicine and Cellular Longevity, Vol. 2019 https://doi.org/10.1155/2019/7017363	journal	January 2019
Catalase, a remarkable enzyme: targeting the oldest antioxidant enzyme to find a new cancer treatment approach Glorieux, Christophe; Calderon, Pedro Buc Biological Chemistry, Vol. 398, Issue 10 https://doi.org/10.1515/hsz-2017-0131	journal	September 2017
Electrode configurations in atmospheric pressure plasma jets: production of reactive species Lietz, Amanda M.; Kushner, Mark J. Plasma Sources Science and Technology, Vol. 27, Issue 10 https://doi.org/10.1088/1361-6595/aadf5b	journal	October 2018
Cold Atmospheric Plasma in the Treatment of Osteosarcoma Gümbel, Denis; Bekeschus, Sander; Gelbrich, Nadine International Journal of Molecular Sciences, Vol. 18, Issue 9 https://doi.org/10.3390/ijms18092004	journal	September 2017
A meta-analysis and review examining a possible role for oxidative stress and singlet oxygen in diverse diseases Petrou, Athinoula L.; Terzidaki, Athina Biochemical Journal, Vol. 474, Issue 16 https://doi.org/10.1042/bcj20161058	journal	August 2017
Gene expression profiling and functional analysis reveals that p53 pathway-related gene expression is highly activated in cancer cells treated by cold atmospheric plasma-activated medium Shi, Lei; Yu, Lihua; Zou, Fagui PeerJ, Vol. 5 https://doi.org/10.7717/peerj.3751	journal	January 2017
Coagulation, deformability, and aggregation of RBCs and platelets following exposure to dielectric barrier discharge plasma with the use of different feeding gases Kim, Jeongho; Ghimire, Bhagirath; Lim, Sinye Journal of Physics D: Applied Physics, Vol. 52, Issue 15 https://doi.org/10.1088/1361-6463/ab0198	journal	February 2019
Use of cold-atmospheric plasma in oncology: a concise systematic review Dubuc, Antoine; Monsarrat, Paul; Virard, François Therapeutic Advances in Medical Oncology, Vol. 10 https://doi.org/10.1177/1758835918786475	journal	January 2018
Physical plasma-treated saline promotes an immunogenic phenotype in CT26 colon cancer cells in vitro and in vivo Freund, Eric; Liedtke, Kim Rouven; van der Linde, Julia Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-018-37169-3	journal	January 2019
Combination of chemotherapy and physical plasma elicits melanoma cell death via upregulation of SLC22A16 Sagwal, Sanjeev Kumar; Pasqual-Melo, Gabriella; Bodnar, Yana Cell Death & Disease, Vol. 9, Issue 12 https://doi.org/10.1038/s41419-018-1221-6	journal	December 2018
Miniature Non-thermal Plasma Induced Cell Cycle Arrest and Apoptosis in Lung Carcinoma Cells Karki, Surya B.; Gupta, Tripti Thapa; Yildirim-Ayan, Eda Plasma Chemistry and Plasma Processing, Vol. 40, Issue 1 https://doi.org/10.1007/s11090-019-10037-2	journal	October 2019
Cold Atmospheric Plasma Induces Apoptosis and Oxidative Stress Pathway Regulation in T-Lymphoblastoid Leukemia Cells Turrini, Eleonora; Laurita, Romolo; Stancampiano, Augusto Oxidative Medicine and Cellular Longevity, Vol. 2017 https://doi.org/10.1155/2017/4271065	journal	January 2017
Modifying the Tumour Microenvironment: Challenges and Future Perspectives for Anticancer Plasma Treatments Privat-Maldonado, Angela; Bengtson, Charlotta; Razzokov, Jamoliddin Cancers, Vol. 11, Issue 12 https://doi.org/10.3390/cancers11121920	journal	December 2019
Combination of chemotherapy and physical plasma elicits melanoma cell death via upregulation of SLC22A16 Sagwal, Sanjeev Kumar; Pasqual-Melo, Gabriella; Bodnar, Yana London [u.a.] : Nature Publishing Group https://doi.org/10.34657/9841	text	January 2018
Cytotoxicity of cancer HeLa cells sensitivity to normal MCF10A cells in cultivations with cell culture medium treated by microwave-excited atmospheric pressure plasmas Takahashi, Yohei; Taki, Yusuke; Takeda, Keigo Journal of Physics D: Applied Physics, Vol. 51, Issue 11 https://doi.org/10.1088/1361-6463/aaab09	journal	February 2018
The kINPen—a review on physics and chemistry of the atmospheric pressure plasma jet and its applications Reuter, Stephan; von Woedtke, Thomas; Weltmann, Klaus-Dieter Journal of Physics D: Applied Physics, Vol. 51, Issue 23 https://doi.org/10.1088/1361-6463/aab3ad	journal	May 2018
A Dielectric Barrier Discharge Plasma Degrades Proteins to Peptides by Cleaving the Peptide Bond Krewing, Marco; Schubert, Britta; Bandow, Julia Elisabeth Plasma Chemistry and Plasma Processing, Vol. 40, Issue 3 https://doi.org/10.1007/s11090-019-10053-2	journal	November 2019

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